Brief Information of the Cell Line and Protein
Cell Line ID: CL000186 , RPMI-8226
Synonyms
RPMI 8226
RPMI.8226
RPMI8226
RPMI no. 8226
RPMI no 8226
RPMI #8226
8226
RPMI 8226/S
RPMI-8226S
RPMI8226/S
8226/S
Roswell Park Memorial Institute 8226
GM02132
GM2132
GM 2132
GM02132C
Simpson
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0014
Protein ID: PT01449 , P2X purinoceptor 7
Gene Name P2RX7
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q99572
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000186  Protein ID: PT01449
 
Compound ID Compound Name Compound Formula
CP0574254
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-6-fluoroindole
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C29H32FN3
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0579323
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]indole
   Show/Hide
C29H33N3
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0579536
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-5-fluoroindole
   Show/Hide
C29H32FN3
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0579326
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-5,6-difluoroindole
   Show/Hide
C29H31F2N3
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0579325
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-4-fluoroindole
   Show/Hide
C29H32FN3
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0550612
3-[4-(4-benzhydrylpiperazin-1-yl)butyl]-1H-benzimidazol-2-one
   Show/Hide
C28H32N4O
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0569692
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]benzimidazole
   Show/Hide
C28H32N4
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0580228
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]pyrrolo[2,3-b]pyridine
   Show/Hide
C28H32N4
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0578516
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]indazole
   Show/Hide
C28H32N4
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0568891
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]pyrrolo[2,3-c]pyridine
   Show/Hide
C28H32N4
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0547281
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]pyrrolo[3,2-b]pyridine
   Show/Hide
C28H32N4
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0580174
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]pyrrolo[3,2-c]pyridine
   Show/Hide
C28H32N4
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0579534
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]benzotriazole
   Show/Hide
C27H31N5
 1
1
IC50 = 480 nM
   TI
   LI
   LO
   TS
CP0568890
3-[5-(4-benzhydrylpiperazin-1-yl)pentyl]-1H-benzimidazol-2-one
   Show/Hide
C29H34N4O
 1
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
CP0568846
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-5,6-dimethylbenzimidazole
   Show/Hide
C30H36N4
 1
1
IC50 = 770 nM
   TI
   LI
   LO
   TS
CP0058606
3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
   Show/Hide
C27H30N4O
 1
1
IC50 = 830 nM
   TI
   LI
   LO
   TS
CP0580227
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-2-methylbenzimidazole
   Show/Hide
C29H34N4
 1
1
IC50 = 850 nM
   TI
   LI
   LO
   TS
CP0580073
3-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1H-benzimidazol-2-one
   Show/Hide
C26H28N4O
 1
1
IC50 = 950 nM
   TI
   LI
   LO
   TS
CP0570101
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-2-phenylbenzimidazole
   Show/Hide
C34H36N4
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0578517
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]indole-3-carbonitrile
   Show/Hide
C30H32N4
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0579165
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-7-methylindole
   Show/Hide
C30H35N3
 1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0545558
3-[3-(4-benzhydrylidenepiperidin-1-yl)propyl]-1H-benzimidazol-2-one
   Show/Hide
C28H29N3O
 1
1
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0574253
1-benzhydryl-4-[4-(5-phenyltetrazol-1-yl)butyl]piperazine
   Show/Hide
C28H32N6
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0576523
1-benzhydryl-4-[4-(2-methylimidazol-1-yl)butyl]piperazine
   Show/Hide
C25H32N4
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0570102
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]indole-5-carbonitrile
   Show/Hide
C30H32N4
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0579324
1-benzhydryl-4-[4-(5-methyltetrazol-1-yl)butyl]piperazine
   Show/Hide
C23H30N6
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0547343
3-[3-[4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)piperazin-1-yl]propyl]-1H-benzimidazol-2-one
   Show/Hide
C29H32N4O
 1
1
IC50 = 5200 nM
   TI
   LI
   LO
   TS
CP0580057
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-4-methylindole
   Show/Hide
C30H35N3
 1
1
IC50 = 5300 nM
   TI
   LI
   LO
   TS
CP0579535
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-6-methylindole
   Show/Hide
C30H35N3
 1
1
IC50 = 6500 nM
   TI
   LI
   LO
   TS
CP0580072
3-[3-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]propyl]-1H-benzimidazol-2-one
   Show/Hide
C28H31N3O2
 1
1
IC50 = 7500 nM
   TI
   LI
   LO
   TS
CP0579539
3-[3-[4-(2,2-diphenylacetyl)piperazin-1-yl]propyl]-1H-benzimidazol-2-one
   Show/Hide
C28H30N4O2
 1
1
IC50 = 7800 nM
   TI
   LI
   LO
   TS
CP0545557
3-[3-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]propyl]-1H-benzimidazol-2-one
   Show/Hide
C20H23FN4O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0567700
methyl 1-[4-(4-benzhydrylpiperazin-1-yl)butyl]indole-7-carboxylate
   Show/Hide
C31H35N3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0571198
3-[(E)-4-(4-benzhydrylpiperazin-1-yl)but-2-enyl]-1H-benzimidazol-2-one
   Show/Hide
C28H30N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0574252
3-[3-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]propyl]-1H-benzimidazol-2-one
   Show/Hide
C21H26N4O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0578518
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-5-methoxyindole
   Show/Hide
C30H35N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579322
3-[3-[4-(4-nitrophenyl)sulfonylpiperazin-1-yl]propyl]-1H-benzimidazol-2-one
   Show/Hide
C20H23N5O5S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579537
1-benzhydryl-4-[4-(1,2,4-triazol-1-yl)butyl]piperazine
   Show/Hide
C23H29N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS