General Information of the Compound
Compound ID
CP0568846
Compound Name
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]-5,6-dimethylbenzimidazole
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Structure
Formula
C30H36N4
Molecular Weight
452.646
Canonical SMILES
Cc1cc2ncn(CCCCN3CCN(CC3)C(c3ccccc3)c3ccccc3)c2cc1C
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InChI
InChI=1S/C30H36N4/c1-24-21-28-29(22-25(24)2)34(23-31-28)16-10-9-15-32-17-19-33(20-18-32)30(26-11-5-3-6-12-26)27-13-7-4-8-14-27/h3-8,11-14,21-23,30H,9-10,15-20H2,1-2H3
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InChIKey
ZOUPOIGLNKBNHX-UHFFFAOYSA-N
Physicochemical Property
logP
5.84054
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
24.3
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168297072
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01449, P2X purinoceptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000186 RPMI-8226 Homo sapiens (Human)  1
1
IC50 = 770 nM
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