General Information of the Compound
Compound ID
CP0578517
Compound Name
1-[4-(4-benzhydrylpiperazin-1-yl)butyl]indole-3-carbonitrile
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Structure
Formula
C30H32N4
Molecular Weight
448.614
Canonical SMILES
N#Cc1cn(CCCCN2CCN(CC2)C(c2ccccc2)c2ccccc2)c2ccccc12
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InChI
InChI=1S/C30H32N4/c31-23-27-24-34(29-16-8-7-15-28(27)29)18-10-9-17-32-19-21-33(22-20-32)30(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,11-16,24,30H,9-10,17-22H2
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InChIKey
GWEOJJABOJFGLF-UHFFFAOYSA-N
Physicochemical Property
logP
5.70038
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
35.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168284093
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01449, P2X purinoceptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000186 RPMI-8226 Homo sapiens (Human)  1
1
IC50 = 1500 nM
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