Brief Information of the Cell Line and Protein
Cell Line ID: CL000109 , COS-1
Synonyms
Cos-1
COS 1
Cos 1
COS1
Cos1
CV-1 in Origin Simian-1
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0223
Protein ID: PT00909 , Peroxisome proliferator-activated receptor delta
Gene Name PPARD
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID Q03181
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000109  Protein ID: PT00909
 
Compound ID Compound Name Compound Formula
CP0039118
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
   Show/Hide
C21H18F3NO3S2
 1
1
EC50 = 2.9 nM
   TI
   LI
   LO
   TS
CP0130403
2-[3-chloro-4-[3-[(3-phenyl-7-propyl-1,2-benzoxazol-6-yl)oxy]propylsulfanyl]phenyl]acetic acid
   Show/Hide
C27H26ClNO4S
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0078110
2-{4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenoxy}-propionic acid
   Show/Hide
C28H29NO6
 1
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
CP0220490
2-[4-[3-[(3-phenyl-7-propyl-1,2-benzoxazol-6-yl)oxy]propoxy]phenoxy]acetic acid
   Show/Hide
C27H27NO6
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0155637
(3-{4-[(3-phenyl-7-propyl-1,2-benzisoxazol-6-yl)oxy]butoxy}phenyl)acetic acid
   Show/Hide
C28H29NO5
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0041706
2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid
   Show/Hide
C22H26O7
 1
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
CP0200400
2-(4-(3-(4-(4-fluorophenoxy)-2-propylphenoxy)propoxy)phenoxy)-2-methylpropanoic acid
   Show/Hide
C28H31FO6
 1
1
EC50 = 55 nM
   TI
   LI
   LO
   TS
CP0499556
2-fluoro-2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
   Show/Hide
C21H17F4NO3S2
 1
1
EC50 = 55 nM
   TI
   LI
   LO
   TS
CP0120419
2-[4-[2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C26H34N2O4
 1
1
EC50 = 90 nM
   TI
   LI
   LO
   TS
CP0781289
(+)-R-Sodium 2-{4-[2-(N-Heptyl-N-(benzoxazol-2-yl)aminoethyl)]phenoxy}propanoate
   Show/Hide
C25H31N2NaO4
 1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0213824
2-(4-(3-(3-phenyl-7-propylbenzo[d]isoxazol-6-yloxy)propoxy)phenyl)acetic acid
   Show/Hide
C27H27NO5
 1
1
EC50 = 147 nM
   TI
   LI
   LO
   TS
CP0036288
(E)-3-{4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-acrylic acid
   Show/Hide
C28H27NO5
 1
1
EC50 = 148 nM
   TI
   LI
   LO
   TS
CP0208054
2-Methyl-2-{4-[4-(3-phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenoxy}-propionic acid
   Show/Hide
C30H33NO6
 1
1
EC50 = 172 nM
   TI
   LI
   LO
   TS
CP0324132
4-{4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-butyric acid
   Show/Hide
C29H31NO5
 1
1
EC50 = 183 nM
   TI
   LI
   LO
   TS
CP0159874
2-(4-(4-(2-chloro-4-(4-fluorophenoxy)phenoxy)butoxy)phenoxy)-2-methylpropanoic acid
   Show/Hide
C26H26ClFO6
 1
1
EC50 = 284 nM
   TI
   LI
   LO
   TS
CP0467415
2-[2-ethyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]-2-fluoroacetic acid
   Show/Hide
C22H19F4NO3S2
 1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
CP0257979
2-Methyl-2-{3-[4-(3-phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenyl}-propionic acid
   Show/Hide
C30H33NO5
 1
1
EC50 = 400 nM
   TI
   LI
   LO
   TS
CP0842871
Sodium 2-{4-[2-(N-Heptyl-N-(benzoxazol-2-yl)amino-ethyl)]-phenoxy}ethanoate
   Show/Hide
C24H29N2NaO4
 1
1
EC50 = 570 nM
   TI
   LI
   LO
   TS
CP0524690
2-fluoro-2-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]-2-propan-2-ylphenoxy]acetic acid
   Show/Hide
C23H21F4NO3S2
 1
1
EC50 = 580 nM
   TI
   LI
   LO
   TS
CP0100328
(E)-3-{4-[4-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenyl}-acrylic acid
   Show/Hide
C29H29NO5
 1
1
EC50 = 640 nM
   TI
   LI
   LO
   TS
CP0812288
(-)-S-Sodium 2-{4-[2-(N-Heptyl-N-(benzoxazol-2-yl)aminoethyl)]phenoxy}propanoate
   Show/Hide
C25H31N2NaO4
 1
1
EC50 = 850 nM
   TI
   LI
   LO
   TS
CP0178891
2,2-Dimethyl-3-{4-[4-(3-phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenyl}-propionic acid
   Show/Hide
C31H35NO5
 1
1
EC50 = 860 nM
   TI
   LI
   LO
   TS
CP0734398
5-(4-(3-(4-phenoxy-2-propylphenoxy)propoxy)-3-propylphenyl)thiazolidine-2,4-dione
   Show/Hide
C30H33NO5S
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0077280
3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-propan-2-yloxypyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C22H29ClF3N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0166769
(E)-3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-propan-2-yloxypyrazol-3-yl]-N-pentylsulfonylprop-2-enamide
   Show/Hide
C22H27ClF3N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0166771
(E)-3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-cyclopropylpyrazol-3-yl]-N-pentylsulfonylprop-2-enamide
   Show/Hide
C22H25ClF3N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0199273
(E)-3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-propan-2-yloxypyrazol-3-yl]-N-(3-methylbutylsulfonyl)prop-2-enamide
   Show/Hide
C22H27ClF3N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0391833
3-[5-butoxy-2-[(2,4-dichlorophenyl)methyl]pyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C22H31Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0391834
(E)-3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-ylpyrazol-3-yl]-N-pentylsulfonylprop-2-enamide
   Show/Hide
C21H27Cl2N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0399018
3-[2-[(2,4-dichlorophenyl)methyl]-5-(2-methoxyethoxy)pyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C21H29Cl2N3O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0416987
(E)-3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-yloxypyrazol-3-yl]-N-pentylsulfonylprop-2-enamide
   Show/Hide
C21H27Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0419494
3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-yloxypyrazol-3-yl]-N-(3-methylbutylsulfonyl)propanamide
   Show/Hide
C21H29Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0439370
3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-cyclopropylpyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C22H27ClF3N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0457462
N-(benzenesulfonyl)-3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-yloxypyrazol-3-yl]propanamide
   Show/Hide
C22H23Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0484754
3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-propan-2-ylpyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C22H29ClF3N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0484758
3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-yloxypyrazol-3-yl]-N-hexylsulfonylpropanamide
   Show/Hide
C22H31Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0484803
3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-ylpyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C21H29Cl2N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0490359
3-[2-[(2,4-dichlorophenyl)methyl]-5-phenylpyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C24H27Cl2N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0490361
N-butylsulfonyl-3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-yloxypyrazol-3-yl]propanamide
   Show/Hide
C20H27Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0495428
N-cyclohexylsulfonyl-3-[2-[(2,4-dichlorophenyl)methyl]-5-propan-2-yloxypyrazol-3-yl]propanamide
   Show/Hide
C22H29Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0496240
3-[2-[(2,4-dichlorophenyl)methyl]-5-phenylmethoxypyrazol-3-yl]-N-pentylsulfonylpropanamide
   Show/Hide
C25H29Cl2N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0504039
(E)-3-[2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-5-(2-methoxyethoxy)pyrazol-3-yl]-N-(3-methylbutylsulfonyl)prop-2-enamide
   Show/Hide
C22H27ClF3N3O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0879880
3-[1-(2,4-Dichlorobenzyl)-3-(pyridin-2-ylmethoxy)-1H-pyrazol-5-yl]-N-(pentylsulfonyl)propanamide hydrochloride
   Show/Hide
C24H29Cl3N4O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0314944
(E)-3-[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy-4-(2-methoxyethoxy)phenyl]-N-pentylsulfonylprop-2-enamide
   Show/Hide
C23H26ClF3N2O6S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0672411
5-(3-{3-[4-(4-Fluoro-3-methyl-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C28H28FNO5S
 1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0645378
5-(4-(3-(4-(4-fluorophenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H26FNO5S
 1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0005387
Avandamet
   Show/Hide
C18H19N3O3S
 2
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
2
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0467414
(2E,4E,8Z,11Z,14Z,17Z)-icosa-2,4,8,11,14,17-hexaenoic acid
   Show/Hide
C20H28O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0646515
5-(3-{3-[4-(4-Fluoro-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C27H26FNO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0651087
5-(3-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H27NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0654439
5-(3-{3-[4-(4-Methoxy-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C28H29NO6S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0654730
5-(4-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H27NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0654731
5-(3-{3-[4-(4-Chloro-3-methyl-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C28H28ClNO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0661032
5-(3-{3-[4-(4-Hydroxy-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C27H27NO6S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0672145
5-(3-{3-[4-(4-Cyclopentyl-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C32H35NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0686397
5-(3-{3-[4-(4-Chloro-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C27H26ClNO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0708518
5-(3-(3-(4-(3,4-dichlorophenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H25Cl2NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0727828
5-(3-{3-[4-(Biphenyl-4-yloxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C33H31NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0782507
5-(3-{3-[4-(4-Isopropyl-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-thiazolidine-2,4-dione
   Show/Hide
C30H33NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0658355
5-(4-(3-(4-(4-methoxyphenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C28H29NO6S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0672440
5-(4-(3-(4-(4-chlorophenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H26ClNO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0677669
5-(3-methoxy-4-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C28H29NO6S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0679717
5-(4-(3-(4-(biphenyl-4-yloxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C33H31NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0680900
5-(3-methyl-4-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C28H29NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0684997
5-(3-chloro-4-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H26ClNO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0705705
5-(4-(3-(4-(4-isobutylphenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C31H35NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0716559
N-(4-(4-(3-(4-(2,4-dioxothiazolidin-5-yl)phenoxy)propoxy)-3-propylphenoxy)phenyl)-4-methylbenzenesulfonamide
   Show/Hide
C34H34N2O7S2
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0761598
5-(4-(4-(4-phenoxy-2-propylphenoxy)butoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C28H29NO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0761841
5-(4-(3-(4-(4-(methylsulfonyl)phenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C28H29NO7S2
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0783387
5-(3-fluoro-4-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
   Show/Hide
C27H26FNO5S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0034705
2-(3-(3-(2-chloro-4-(4-fluorophenoxy)phenoxy)propoxy)phenoxy)-2-methylpropanoic acid
   Show/Hide
C25H24ClFO6
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0077688
2-(4-(3-(2-chloro-4-(4-fluorophenoxy)phenoxy)propoxy)phenoxy)-2-methylpropanoic acid
   Show/Hide
C25H24ClFO6
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS