| Compound ID |
Compound Name |
Compound Formula |
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CP0349435
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N-[(1R)-1-(3-chloro-4-cyanophenyl)propyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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C23H27ClN6O2
|
1
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| 1 |
IC50 = 4 nM
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CP0303695
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N-[(1R)-1-(3,4-dichlorophenyl)ethyl]-2-[[(2R,4S)-2-(hydroxymethyl)oxan-4-yl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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C22H27Cl2N5O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
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CP0557710
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N-[(1R)-1-(4-chloro-3-fluorophenyl)ethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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C21H25ClFN5O2
|
1
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| 1 |
IC50 = 12 nM
|
|
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CP0198636
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N-[(1R)-1-(3-chloro-4-methoxyphenyl)propyl]-2-[[(2S)-1-hydroxypropan-2-yl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C21H28ClN5O3
|
1
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| 1 |
IC50 = 14 nM
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|
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CP0056201
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N-[(1S)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C21H25Cl2N5O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
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CP0056202
|
N-[(1R)-1-(1H-indol-6-yl)ethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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C23H28N6O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
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CP0400275
|
N-[(1R)-1-(3,4-dichlorophenyl)ethyl]-2-[[(2S)-1-hydroxypropan-2-yl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C19H23Cl2N5O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
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CP0360937
|
N-[(1R)-1-(3,4-dichlorophenyl)ethyl]-2-[(2-methylpyridin-4-yl)amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C22H22Cl2N6O
|
1
|
| 1 |
IC50 = 23 nM
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|
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CP0536705
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N-[(1R)-1-(3,4-dichlorophenyl)propyl]-2-[[(2S)-1-hydroxypropan-2-yl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C20H25Cl2N5O2
|
1
|
| 1 |
IC50 = 23 nM
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|
|
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CP0022357
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N-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C21H25ClFN5O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
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CP0658376
|
(R)-N-(1-(3,4-dichlorophenyl)ethyl)-2-(1-methyl-1H-pyrazol-4-ylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxamide
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|
C20H21Cl2N7O
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
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CP0772158
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(R)-N-(1-(3,4-dichlorophenyl)ethyl)-2-(1-methyl-1H-pyrazol-5-ylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxamide
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|
C20H21Cl2N7O
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
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CP0030172
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C21H25ClFN5O3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
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CP0264544
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N-[(1R)-1-(3,4-difluorophenyl)propyl]-2-[[(2S)-1-hydroxypropan-2-yl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C20H25F2N5O2
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
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CP0537682
|
N-[(1S,2R)-1-(3-chloro-4-fluorophenyl)-2-hydroxypropyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C20H25ClFN5O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
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CP0556626
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N-[(1S,2S)-1-(3-chloro-4-fluorophenyl)-2-hydroxybutyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C21H27ClFN5O2
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
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CP0508480
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N-[(1R)-1-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-2-[[(2S)-1-hydroxypropan-2-yl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
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|
C20H23F4N5O2
|
1
|
| 1 |
IC50 = 110 nM
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|
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CP0400274
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-(methylamino)ethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C20H26ClFN6O
|
1
|
| 1 |
IC50 = 144 nM
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|
|
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CP0031747
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C19H23ClFN5O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
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CP0555042
|
N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-[[(1S,3S)-3-hydroxycyclopentyl]amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C21H25ClFN5O3
|
1
|
| 1 |
IC50 = 198 nM
|
|
|
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CP0283608
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N-[(1S,2S)-1-(3-chloro-4-fluorophenyl)-2-hydroxypropyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C20H25ClFN5O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
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CP0483749
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-[(1-methylpyrazol-4-yl)amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C20H21ClFN7O2
|
1
|
| 1 |
IC50 = 247 nM
|
|
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CP0508505
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(cyclopentylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C21H25ClFN5O2
|
1
|
| 1 |
IC50 = 330 nM
|
|
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CP0396956
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(4-fluoroanilino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C22H20ClF2N5O2
|
1
|
| 1 |
IC50 = 348 nM
|
|
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CP0272776
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N-[(1S)-2-amino-1-(3-chloro-4-fluorophenyl)ethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C19H24ClFN6O
|
1
|
| 1 |
IC50 = 356 nM
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CP0532710
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-methoxyethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C20H25ClFN5O2
|
1
|
| 1 |
IC50 = 368 nM
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CP0550843
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-[(2-methylpyridin-4-yl)amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C22H22ClFN6O2
|
1
|
| 1 |
IC50 = 445 nM
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CP0846012
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N-((S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-2-((S)-1-hydroxypropan-2-ylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxamide
Show/Hide
|
C19H23ClFN5O3
|
1
|
| 1 |
IC50 = 473 nM
|
|
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CP0957781
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(S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-2-(isobutylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxamide
Show/Hide
|
C20H25ClFN5O2
|
1
|
| 1 |
IC50 = 513 nM
|
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CP0532711
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(ethylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H21ClFN5O2
|
1
|
| 1 |
IC50 = 753 nM
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CP0132840
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-(methanesulfonamido)ethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C20H26ClFN6O3S
|
1
|
| 1 |
IC50 = 917 nM
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CP0550842
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N-[(3-chloro-4-fluorophenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H21ClFN5O
|
1
|
| 1 |
IC50 = 1216 nM
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CP0400273
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N-[(4-chloro-3-fluorophenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H21ClFN5O
|
1
|
| 1 |
IC50 = 1628 nM
|
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CP0375374
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N-[(3-chlorophenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H22ClN5O
|
1
|
| 1 |
IC50 = 1856 nM
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CP0375307
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-(2-methoxyethoxy)ethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C22H29ClFN5O3
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1
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| 1 |
IC50 = 2109 nM
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CP0553446
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N-[(4-chlorophenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H22ClN5O
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1
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| 1 |
IC50 = 2138 nM
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CP0483748
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(methylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
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C17H19ClFN5O2
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1
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| 1 |
IC50 = 2255 nM
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CP0375309
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(2-hydroxyethylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
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C18H21ClFN5O3
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1
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| 1 |
IC50 = 2450 nM
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CP0410509
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N-[(3-fluorophenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
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C18H22FN5O
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1
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| 1 |
IC50 = 2611 nM
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CP0556628
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-(2-hydroxyethylamino)ethyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
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C21H28ClFN6O2
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1
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| 1 |
IC50 = 2757 nM
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CP0396955
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2-(tert-butylamino)-N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
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C20H25ClFN5O2
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1
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| 1 |
IC50 = 3009 nM
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CP0555115
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N-benzyl-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H23N5O
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1
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| 1 |
IC50 = 4384 nM
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CP0537681
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N-[(4-methoxyphenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C19H25N5O2
|
1
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| 1 |
IC50 = 4400 nM
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CP0536702
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N-[(4-fluorophenyl)methyl]-2-(propan-2-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C18H22FN5O
|
1
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| 1 |
IC50 = 6620 nM
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CP0531747
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2-acetamido-N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
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C18H19ClFN5O3
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1
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| 1 |
IC50 = 7438 nM
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CP0097585
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N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-[(3,5-dimethyl-1,2-oxazol-4-yl)amino]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
Show/Hide
|
C21H22ClFN6O3
|
1
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| 1 |
IC50 = 13238 nM
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