| Compound ID |
Compound Name |
Compound Formula |
|
CP0386652
|
US9447114, 26
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|
C24H20ClF3N2O4S
|
2
|
| 1 |
IC50 < 1 nM
|
|
|
| 2 |
IC50 = 1.91 nM
|
|
|
|
CP0387659
|
US9447114, 2
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|
C23H20Cl2N2O4S
|
2
|
| 1 |
IC50 < 1 nM
|
|
|
| 2 |
IC50 = 117 nM
|
|
|
|
CP0399857
|
US9447114, 27
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|
C23H20Cl2N2O4
|
2
|
| 1 |
IC50 < 1 nM
|
|
|
| 2 |
IC50 = 134 nM
|
|
|
|
CP0406957
|
US9447114, 1
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|
C24H20ClF3N2O5S
|
2
|
| 1 |
IC50 < 1 nM
|
|
|
| 2 |
IC50 = 584 nM
|
|
|
|
CP0528227
|
6-butoxy-5-[(4-fluorophenyl)methyl]-3-(3-hydroxypropyl)-1-methylquinazoline-2,4-dione
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|
C23H27FN2O4
|
1
|
| 1 |
IC50 < 1 nM
|
|
|
|
CP0417615
|
5-benzyl-3-(3-hydroxypropyl)-1-methyl-6-[3-(trifluoromethoxy)phenoxy]quinazoline-2,4-dione
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|
C26H23F3N2O5
|
2
|
| 1 |
IC50 < 1 nM
|
|
|
| 2 |
IC50 = 2.69 nM
|
|
|
|
CP0491869
|
US9447114, 24
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|
C23H20Cl2N2O3S
|
2
|
| 1 |
IC50 = 1.84 nM
|
|
|
| 2 |
IC50 = 242 nM
|
|
|
|
CP0430245
|
5-[(4-fluorophenyl)methyl]-3-(3-hydroxypropyl)-1-methyl-6-propan-2-yloxyquinazoline-2,4-dione
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|
C22H25FN2O4
|
2
|
| 1 |
IC50 = 2.64 nM
|
|
|
| 2 |
IC50 = 9 nM
|
|
|
|
CP0426913
|
5-benzyl-3-(3-hydroxypropyl)-1-methyl-6-[3-(trifluoromethoxy)phenyl]quinazoline-2,4-dione
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|
C26H23F3N2O4
|
2
|
| 1 |
IC50 = 5.3 nM
|
|
|
| 2 |
IC50 = 31.2 nM
|
|
|
|
CP0477321
|
5-[(4-fluorophenyl)methyl]-3-(3-hydroxypropyl)-6-methoxy-1-methylquinazoline-2,4-dione
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|
C20H21FN2O4
|
2
|
| 1 |
IC50 = 8.37 nM
|
|
|
| 2 |
IC50 > 100 nM
|
|
|
|
CP0491870
|
US9447114, 25
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|
C17H17ClN2O3S
|
2
|
| 1 |
IC50 = 15.7 nM
|
|
|
| 2 |
IC50 = 168 nM
|
|
|
|
CP0562463
|
US9447114, 13
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|
C18H17F3N2O4S
|
1
|
| 1 |
IC50 < 21 nM
|
|
|
|
CP0553015
|
5-benzyl-3-(3-hydroxypropyl)-6-methoxy-1-methylquinazoline-2,4-dione
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|
C20H22N2O4
|
2
|
| 1 |
IC50 = 23.3 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0399856
|
US9447114, 23
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|
C23H20Cl2N2O3S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0426914
|
US9447114, 5
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|
C17H16Cl2N2O3S
|
1
|
| 1 |
IC50 < 27 nM
|
|
|
|
CP0426916
|
US9447114, 16
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|
C17H17ClN2O3S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0465902
|
US9447114, 18
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|
C17H17FN2O3S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0565230
|
US9447114, 6
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|
C18H16F4N2O3S
|
1
|
| 1 |
IC50 < 27 nM
|
|
|
|
CP0475507
|
US9447114, 17
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|
C17H16Cl2N2O3S
|
1
|
| 1 |
IC50 = 31.6 nM
|
|
|
|
CP0399854
|
US9447114, 7
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|
C21H20N2O3S
|
1
|
| 1 |
IC50 = 34.9 nM
|
|
|
|
CP0930985
|
4-chloro-5-(4-((4-fluoro-2-(trifluoromethyl)phenyl)(2-hydroxyethyl)amino)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)pyridazin-3(2H)-one
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|
C20H17ClF4N6O2
|
1
|
| 1 |
IC50 <= 50 nM
|
|
|
|
CP0957398
|
4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)pyridazin-3(2H)-one
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|
C18H12ClF4N5O2
|
1
|
| 1 |
IC50 <= 50 nM
|
|
|
|
CP0965479
|
4-chloro-5-(4-(2-chloro-4-fluorophenoxy)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)pyridazin-3(2H)-one
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|
C17H12Cl2FN5O2
|
1
|
| 1 |
IC50 <= 50 nM
|
|
|
|
CP0967997
|
4-chloro-5-(4-(2-(trifluoromethyl)phenoxy)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)pyridazin-3(2H)-one
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|
C18H13ClF3N5O2
|
1
|
| 1 |
IC50 <= 50 nM
|
|
|
|
CP0969973
|
4-chloro-5-(4-(2-ethyl-3-fluorophenoxy)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)pyridazin-3(2H)-one
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|
C19H17ClFN5O2
|
1
|
| 1 |
IC50 <= 50 nM
|
|
|
|
CP0969974
|
4-chloro-5-(4-(methyl(4-(trifluoromethyl)pyridin-3-yl)amino)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)pyridazin-3(2H)-one
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|
C18H15ClF3N7O
|
1
|
| 1 |
IC50 <= 50 nM
|
|
|
|
CP0386651
|
US9447114, 4
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|
C23H20Cl2N2O4S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0426915
|
US9447114, 14
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|
C18H17F3N2O4S
|
1
|
| 1 |
IC50 = 82.2 nM
|
|
|
|
CP0399855
|
US9447114, 15
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|
C17H16F2N2O3S
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0561959
|
US9447114, 21
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|
C24H20ClF3N2O6S
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0393343
|
US9447114, 19
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|
C17H17ClN2O3S
|
1
|
| 1 |
IC50 = 226 nM
|
|
|
|
CP0402751
|
US9447114, 3
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|
C22H25F3N2O4S
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0561960
|
US9447114, 22
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|
C22H25F3N2O5S
|
1
|
| 1 |
IC50 = 369 nM
|
|
|
|
CP0465901
|
US9447114, 8
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|
C16H16ClN3O3S
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0538599
|
US9447114, 28
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|
C25H24Cl2N2O5
|
1
|
| 1 |
IC50 = 4330 nM
|
|
|
