General Information of the Compound
Compound ID
CP0387659
Compound Name
US9447114, 2
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Structure
Formula
C23H20Cl2N2O4S
Molecular Weight
491.396
Canonical SMILES
Cn1c2sc(Oc3cccc(Cl)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
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InChI
InChI=1S/C23H20Cl2N2O4S/c1-26-21-19(20(29)27(23(26)30)10-3-11-28)18(12-14-6-8-15(24)9-7-14)22(32-21)31-17-5-2-4-16(25)13-17/h2,4-9,13,28H,3,10-12H2,1H3
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InChIKey
KHAGCYOTZHGFQM-UHFFFAOYSA-N
Physicochemical Property
logP
4.834
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
73.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118863125
ChEMBL ID
CHEMBL3946580
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05452, Short transient receptor potential channel 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  2
1
IC50 < 1 nM
   TI
   LI
   LO
   TS
2
IC50 = 117 nM
   TI
   LI
   LO
   TS