General Information of the Compound
Compound ID
CP0430245
Compound Name
5-[(4-fluorophenyl)methyl]-3-(3-hydroxypropyl)-1-methyl-6-propan-2-yloxyquinazoline-2,4-dione
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Structure
Formula
C22H25FN2O4
Molecular Weight
400.45
Canonical SMILES
CC(C)Oc1ccc2n(C)c(=O)n(CCCO)c(=O)c2c1Cc1ccc(F)cc1
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InChI
InChI=1S/C22H25FN2O4/c1-14(2)29-19-10-9-18-20(17(19)13-15-5-7-16(23)8-6-15)21(27)25(11-4-12-26)22(28)24(18)3/h5-10,14,26H,4,11-13H2,1-3H3
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InChIKey
XUMKYAVJJZYABR-UHFFFAOYSA-N
Physicochemical Property
logP
2.5997
Rotatable Bonds
7
Heavy Atom Count
29
Polar Areas
73.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118869706
ChEMBL ID
CHEMBL4466158
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05452, Short transient receptor potential channel 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  2
1
IC50 = 2.64 nM
   TI
   LI
   LO
   TS
2
IC50 = 9 nM
   TI
   LI
   LO
   TS