| Compound ID |
Compound Name |
Compound Formula |
|
CP0382814
|
2-amino-6-[(3-bromo-4-chlorophenyl)methyl]-5-propan-2-yl-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
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C15H15BrClN5O
|
7
|
| 1 |
EC50 = 12.3 nM
|
|
|
| 2 |
EC50 = 13 nM
|
|
|
| 3 |
EC50 = 29.51 nM
|
|
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| 4 |
EC50 = 32 nM
|
|
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| 5 |
EC50 = 134.9 nM
|
|
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| 6 |
EC50 = 148 nM
|
|
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| 7 |
IC50 = 4 nM
|
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|
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CP0355426
|
2-amino-6-[(2,3-dichlorophenyl)methyl]-5-propan-2-yl-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
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|
C15H15Cl2N5O
|
7
|
| 1 |
EC50 = 12.88 nM
|
|
|
| 2 |
EC50 = 13 nM
|
|
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| 3 |
EC50 = 25.12 nM
|
|
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| 4 |
EC50 = 26 nM
|
|
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| 5 |
EC50 = 53.7 nM
|
|
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| 6 |
EC50 = 56 nM
|
|
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| 7 |
IC50 = 21 nM
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CP0382613
|
2-amino-6-[(3-chlorophenyl)methyl]-5-cyclopropyl-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
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|
C15H14ClN5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
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CP0666580
|
Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium chloride(TAK-779)
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|
C33H39ClN2O2
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
Ki = 2 nM
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|
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CP0355486
|
N-[4-[[methyl(oxan-4-yl)amino]methyl]phenyl]-7-(4-methylphenyl)-2-(2-methylpropyl)-1-oxo-3H-2-benzazepine-4-carboxamide
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|
C35H41N3O3
|
1
|
| 1 |
IC50 = 387 nM
|
|
|
|
CP0547414
|
[(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
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|
C24H34F3N3O3
|
2
|
| 1 |
Kd = 0.48 nM
|
|
|
| 2 |
Ki = 0.55 nM
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CP0400532
|
[(1S,3R)-3-[(5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C30H37F3N2O3
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0389432
|
[(1S,3R)-3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32ClF3N2O
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0400522
|
[(1S,3R)-3-[[(1S,3R)-5-bromo-3-methyl-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H34BrF3N2O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
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CP0494977
|
[(1S,3R)-3-[(5-bromo-3-methyl-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H34BrF3N2O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0389431
|
[(1S,3R)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H33F3N2O
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0400530
|
[(1S,3R)-3-[(5-bromo-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32BrF3N2O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0400538
|
[(1S,3R)-3-[[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32BrF3N2O
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0489216
|
[(1S,3R)-3-[(3-methyl-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H35F3N2O
|
1
|
| 1 |
Ki = 3.4 nM
|
|
|
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CP0428763
|
[(1S,3R)-3-[(5-iodo-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32F3IN2O
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
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CP0400534
|
[(1S,3R)-3-[(5-bromo-6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H34BrF3N2O2
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0400535
|
[(1S,3R)-3-[[(1S,3S)-5-bromo-3-methyl-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H34BrF3N2O
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0547443
|
[(1S,3R)-3-[(4-amino-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H34F3N3O
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0400531
|
[(1S,3R)-3-[(5-fluoro-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32F4N2O
|
1
|
| 1 |
Ki = 4.9 nM
|
|
|
|
CP0414185
|
[(1S,3R)-3-[(6-chloro-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32ClF3N2O
|
1
|
| 1 |
Ki = 7.9 nM
|
|
|
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CP0400526
|
[(1S,3R)-1-propan-2-yl-3-[(5-pyridin-3-yl-2,3-dihydro-1H-inden-1-yl)amino]cyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C33H36F3N3O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
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CP0478180
|
[(1S,3R)-3-[[5-(5-ethoxypyridin-3-yl)-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C35H40F3N3O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0428762
|
4-[1-[[(1R,3S)-3-propan-2-yl-3-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclopentyl]amino]-2,3-dihydro-1H-inden-5-yl]benzonitrile
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|
C35H36F3N3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
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CP0482654
|
[(1S,3R)-3-[[5-(5-fluoro-2-methoxypyridin-4-yl)-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C34H37F4N3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0389430
|
[(1S,3R)-1-propan-2-yl-3-[[5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]amino]cyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H32F6N2O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
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CP0389433
|
3-[[(1R,3S)-3-propan-2-yl-3-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclopentyl]amino]-2,3-dihydro-1H-indene-5-carbonitrile
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|
C29H32F3N3O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
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CP0487034
|
[(1S,3R)-3-[(5-bromo-6-methoxy-3-methyl-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C30H36BrF3N2O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
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CP0400520
|
[(1S,3R)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-propan-2-ylcyclopentyl]-[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone
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|
C28H35F3N4O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
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CP0412816
|
1-[[(1R,3S)-3-propan-2-yl-3-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclopentyl]amino]-2,3-dihydro-1H-indene-4-carbonitrile
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|
C29H32F3N3O
|
1
|
| 1 |
Ki = 15 nM
|
|
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CP0481222
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[(1S,3R)-3-[(4-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H33F3N2O2
|
1
|
| 1 |
Ki = 21 nM
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CP0489215
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[(1S,3R)-3-[(6-methyl-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H35F3N2O
|
1
|
| 1 |
Ki = 23 nM
|
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CP0491297
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[(1S,3R)-3-[[5-(2-methoxypyridin-4-yl)-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C34H38F3N3O2
|
1
|
| 1 |
Ki = 23 nM
|
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CP0400524
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[(1S,3R)-3-[[(1S)-5-bromo-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C28H32BrF3N2O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
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CP0489214
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[(1S,3R)-3-[(4-methyl-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H35F3N2O
|
1
|
| 1 |
Ki = 31 nM
|
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|
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CP0414186
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[(1S,3R)-3-[[5-(3-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C35H39F3N2O2
|
1
|
| 1 |
Ki = 39 nM
|
|
|
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CP0428761
|
[(1S,3R)-3-[[5-(5-methoxypyridin-3-yl)-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C34H38F3N3O2
|
1
|
| 1 |
Ki = 41 nM
|
|
|
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CP0400533
|
[(1S,3R)-3-[(4,7-dimethoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C30H37F3N2O3
|
1
|
| 1 |
Ki = 49 nM
|
|
|
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CP0331716
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-isopropylcyclopentanecarboxamide
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|
C27H30F6N2O
|
1
|
| 1 |
Ki = 50 nM
|
|
|
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CP0494978
|
3-[1-[[(1R,3S)-3-propan-2-yl-3-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclopentyl]amino]-2,3-dihydro-1H-inden-5-yl]benzonitrile
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|
C35H36F3N3O
|
1
|
| 1 |
Ki = 55 nM
|
|
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CP0425963
|
N-[2-[[1-[4-(3-methoxyphenyl)cyclohexyl]piperidin-4-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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|
C28H34F3N3O3
|
1
|
| 1 |
Ki = 66 nM
|
|
|
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CP0425987
|
N-[2-oxo-2-[[1-(4-phenylcyclohexyl)piperidin-4-yl]amino]ethyl]-3-(trifluoromethyl)benzamide
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|
C27H32F3N3O2
|
1
|
| 1 |
Ki = 74 nM
|
|
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CP0400528
|
[(1S,3R)-3-[[5-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C35H39F3N2O2
|
1
|
| 1 |
Ki = 75 nM
|
|
|
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CP0499191
|
[(1S,3R)-3-[(5-bromo-3-ethyl-6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C31H38BrF3N2O2
|
1
|
| 1 |
Ki = 83 nM
|
|
|
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CP0556328
|
N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]piperidin-4-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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|
C28H32F3N3O4
|
1
|
| 1 |
Ki = 90 nM
|
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|
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CP0389428
|
[(1S,3R)-3-[[(1R,3S)-5-bromo-3-methyl-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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|
C29H34BrF3N2O
|
1
|
| 1 |
Ki = 137 nM
|
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CP0410717
|
N-[2-[[1-[4-(4-hydroxyphenyl)cyclohexyl]piperidin-4-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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|
C27H32F3N3O3
|
1
|
| 1 |
Ki = 139 nM
|
|
|
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CP0488211
|
[(1S,3R)-3-[[(1R,3R)-5-bromo-3-methyl-2,3-dihydro-1H-inden-1-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
Show/Hide
|
C29H34BrF3N2O
|
1
|
| 1 |
Ki = 199 nM
|
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CP0425962
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N-[2-[[1-[4-(3-methylphenyl)cyclohexyl]piperidin-4-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H34F3N3O2
|
1
|
| 1 |
Ki = 270 nM
|
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|
