Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT00886 , Estrogen receptor
Gene Name ESR1
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID P03372
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043  Protein ID: PT00886
 
Compound ID Compound Name Compound Formula
CP0006292
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
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C18H24O2
 3
1
EC50 = 0.019 nM
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2
EC50 = 2.773 nM
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3
IC50 = 21.04 nM
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CP0080858
1,3-Diethyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C19H20O2
 1
1
EC50 = 0.059 nM
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CP0062959
PROPYLPYRAZOLETRIOL
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C24H22N2O3
 1
1
EC50 = 0.1 nM
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CP0121204
4-[3,5-bis(4-hydroxyphenyl)-1-propylpyrrol-2-yl]-3-fluorophenol
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C25H22FNO3
 1
1
EC50 = 0.12 nM
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CP0335581
4-[4,5-bis(2-fluoro-4-hydroxyphenyl)-1-propylpyrrol-2-yl]-3-fluorophenol
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C25H20F3NO3
 1
1
EC50 = 0.2 nM
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CP0138900
3-fluoro-4-[5-(2-fluoro-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-1-propylpyrrol-2-yl]phenol
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C25H21F2NO3
 1
1
EC50 = 0.27 nM
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CP0254889
1-Ethyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C17H16O2
 1
1
EC50 = 0.31 nM
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CP0138898
4-[3,5-bis(4-hydroxyphenyl)-1-propylpyrrol-2-yl]-3-chlorophenol
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C25H22ClNO3
 1
1
EC50 = 0.31 nM
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CP0243845
4-[4,5-bis(4-hydroxyphenyl)-1-propylpyrrol-2-yl]phenol
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C25H23NO3
 1
1
EC50 = 0.4 nM
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CP0243842
4-[4,5-bis(4-hydroxyphenyl)-1-propylpyrrol-2-yl]-3-fluorophenol
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C25H22FNO3
 1
1
EC50 = 0.67 nM
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CP0259219
4-[2,5-bis(4-hydroxyphenyl)-1-propylpyrrol-3-yl]-3-fluorophenol
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C25H22FNO3
 1
1
EC50 = 0.84 nM
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CP0138897
4-[1,5-bis(4-hydroxyphenyl)-4-propylpyrrol-3-yl]phenol
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C25H23NO3
 1
1
EC50 = 1.6 nM
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CP0269771
1-(4-Fluoro-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C21H15FO2
 1
1
EC50 = 3.9 nM
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CP0171370
2-(4-Hydroxy-phenyl)-1-phenyl-3H-inden-5-ol
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C21H16O2
 1
1
EC50 = 4.3 nM
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CP0319985
1-(4-Amino-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C21H17NO2
 1
1
EC50 = 6.7 nM
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CP0179169
1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol
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C21H16O3
 1
1
EC50 = 7 nM
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CP0319986
1-Benzyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C22H18O2
 1
1
EC50 = 14 nM
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CP0166061
2-(4-Hydroxy-phenyl)-1-(4-trifluoromethyl-phenyl)-3H-inden-5-ol
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C22H15F3O2
 1
1
EC50 = 15 nM
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CP0243840
3-fluoro-4-[5-(2-fluoro-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-1-methylpyrrol-2-yl]phenol
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C23H17F2NO3
 1
1
EC50 = 15 nM
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CP0243841
4-[3,5-bis(4-hydroxyphenyl)-1-methylpyrrol-2-yl]-3-chlorophenol
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C23H18ClNO3
 1
1
EC50 = 16 nM
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CP0220902
1-(4-Chloro-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C21H15ClO2
 1
1
EC50 = 17 nM
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CP0273667
2-(4-Hydroxy-phenyl)-1-p-tolyl-3H-inden-5-ol
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C22H18O2
 1
1
EC50 = 17 nM
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CP0243843
4-[4,5-bis(4-hydroxyphenyl)-1-methylpyrrol-2-yl]-3-fluorophenol
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C23H18FNO3
 1
1
EC50 = 24 nM
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CP0374954
(8R,9S,13S,14S,17R)-17-[(E)-4,4,5,5,6,6,6-heptafluorohex-1-enyl]-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
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C24H27F7O2
 2
1
EC50 = 35.48 nM
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2
IC50 < 15848.93 nM
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CP0138901
4-[4,5-bis(4-hydroxyphenyl)-1-propylpyrrol-2-yl]-3-chlorophenol
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C25H22ClNO3
 1
1
EC50 = 47 nM
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CP0335580
4-[3,5-bis(4-hydroxyphenyl)-1-methylpyrrol-2-yl]-3-fluorophenol
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C23H18FNO3
 1
1
EC50 = 60 nM
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CP0076766
3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid [4-(2-piperidin-1-yl-ethoxy)-phenyl]-amide
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C31H34N2O4
 1
1
EC50 = 100 nM
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CP0335571
4-[4,5-bis(4-hydroxyphenyl)-1-methylpyrrol-2-yl]-3-chlorophenol
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C23H18ClNO3
 1
1
EC50 = 100 nM
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CP0276695
1-(4-Bromomethyl-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5-ol
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C22H17BrO2
 1
1
EC50 = 109 nM
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CP0280338
3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid [4-(2-dimethylamino-ethoxy)-phenyl]-amide
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C28H30N2O4
 1
1
EC50 = 152 nM
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CP0076765
3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid
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C18H16O4
 1
1
EC50 = 158 nM
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CP0427567
(8R,9S,13S,14S,17R)-13-methyl-17-[(E)-5,6,6,6-tetrafluoro-5-(trifluoromethyl)hex-2-enyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
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C25H29F7O2
 2
1
EC50 = 402.72 nM
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2
IC50 < 15848.93 nM
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CP0319983
3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid (4-hydroxy-phenyl)-amide
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C24H21NO4
 1
1
EC50 = 427 nM
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CP0387718
(8R,9S,13S,14S,17R)-17-[(E)-5,5,6,6,7,7,7-heptafluorohept-2-enyl]-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
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C25H29F7O2
 2
1
EC50 = 485.29 nM
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2
IC50 < 15848.93 nM
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CP0386424
(8R,9S,13S,14S,17R)-13-methyl-17-[(E)-5,5,6,6,7,7,8,8,9,9,10,10,10-tridecafluorodec-2-enyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
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C28H29F13O2
 2
1
EC50 = 1028.02 nM
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2
IC50 < 15848.93 nM
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CP0380441
(8R,9S,13S,14S,17R)-17-[(E)-5,5,6,6,7,7,7-heptafluorohept-2-enyl]-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
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C26H31F7O2
 2
1
EC50 = 1655.77 nM
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2
IC50 < 15848.93 nM
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CP0372764
(8R,9S,13S,14S,17R)-13-methyl-17-[(E)-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoronon-1-enyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
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C27H27F13O2
 2
1
EC50 = 2079.7 nM
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2
IC50 < 15848.93 nM
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CP0375884
(8R,9S,13S,14S,17R)-17-[(E)-4,4,5,5,6,6,6-heptafluorohex-1-enyl]-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
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C25H29F7O2
 2
1
EC50 = 4027.17 nM
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2
IC50 < 15848.93 nM
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CP0375887
(8R,9S,13S,14S,17R)-13-methyl-17-[(E)-4,5,5,5-tetrafluoro-4-(trifluoromethyl)pent-1-enyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
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C24H27F7O2
 2
1
EC50 = 9954.05 nM
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2
IC50 < 15848.93 nM
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CP0380442
(8R,9S,13S,14S,17R)-3-methoxy-13-methyl-17-[(E)-5,5,6,6,7,7,8,8,9,9,10,10,10-tridecafluorodec-2-enyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
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C29H31F13O2
 2
1
EC50 < 15848.93 nM
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2
IC50 < 15848.93 nM
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CP0846678
1'-(E)-[(3-Methoxy-17-(4',4',5',5',6',6',7',7',8',8',9',9',9'-tridecafluoronon-1'-en-1'-yl)estra-17beta-ol]
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C28H29F13O2
 2
1
EC50 < 15848.93 nM
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2
IC50 < 15848.93 nM
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CP0240380
4-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
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C26H29NO2
 1
1
IC50 = 2.28 nM
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CP0045086
4-Hydroxytamoxifen
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C26H29NO2
 1
1
IC50 = 2.3 nM
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CP0943751
2-(3-(4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamido)ethanaminium 2,2,2-trifluoroacetate
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C29H29F3N2O4
 1
1
IC50 = 5.3 nM
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CP0317701
(E)-N-(2-aminoethyl)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enamide;2,2,2-trifluoroacetic acid
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C33H31F9N2O8
 1
1
IC50 = 5.33 nM
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CP0833947
3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)-N-(5-(3-(5-methoxy-1H-benzo(d)imidazol-2-yl)-propanamido)pentyl)acrylamide
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C41H44N4O4
 1
1
IC50 = 9.2 nM
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CP0835418
3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)-N-(6-(3-(5-methoxy-1H-benzo(d)imidazol-2-yl)-propanamido)hexyl)acrylamide
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C42H46N4O4
 1
1
IC50 = 9.4 nM
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CP0776597
3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)-N-(2-(3-(5-methoxy-1H-benzo(d)imidazol-2-yl)-propanamido)ethyl)acrylamide
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C38H38N4O4
 1
1
IC50 = 9.7 nM
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CP0950473
N-[4-(3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamido)butyl]-8-(4-oxo-2-thioxodihydroquinazolin-3-yl)octanamide
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C45H50N4O4S
 1
1
IC50 = 18.5 nM
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CP0944381
(E/Z)-N-[6-(3-(5-Hydroxy-1H-benzo[d]imidazol-2-yl)-propanamido)hexyl]-3-[4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl]acrylamide
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C41H44N4O4
 1
1
IC50 = 20 nM
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CP0835412
3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)-N-(3-(3-(5-methoxy-1H-benzo(d)imidazol-2-yl)-propanamido)propyl)acrylamide
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C39H40N4O4
 1
1
IC50 = 21.5 nM
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CP0960446
N-(2-(3-(5-Hydroxy-1H-benzo(d)imidazol-2-yl)-propanamido)ethyl)-3-(4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamide
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C37H36N4O4
 1
1
IC50 = 26 nM
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CP0835404
N-(3-(3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamido)propyl)-4-(4-oxo-2-thioxodihydroquinazolin-3-yl)butanamide
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C40H40N4O4S
 1
1
IC50 = 30.2 nM
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CP0835419
(E)-N-[5-(3-(5-Hydroxy-1H-benzo[d]imidazol-2-yl)-propanamido)pentyl]-3-[4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl]acrylamide
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C40H42N4O4
 1
1
IC50 = 30.9 nM
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CP0835416
3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)-N-(4-(3-(5-methoxy-1H-benzo(d)imidazol-2-yl)-propanamido)butyl)acrylamide
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C40H42N4O4
 1
1
IC50 = 34.5 nM
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CP0557200
(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]-N-[5-[[(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]prop-2-enoyl]amino]pentyl]prop-2-enamide
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C49H54N2O4
 1
1
IC50 = 73 nM
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CP0833945
N-[3-(3-(5-Hydroxy-1H-benzo[d]imidazol-2-yl)-propanamido)propyl]-3-[4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl]acrylamide
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C38H38N4O4
 1
1
IC50 = 80.8 nM
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CP0317700
(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]-N-[4-[[(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]prop-2-enoyl]amino]butyl]prop-2-enamide
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C48H52N2O4
 1
1
IC50 = 88.3 nM
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CP0960445
N-[3-(3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamido)propyl]-4-[4-(4-(4-oxo-2-thioxodihydroquinazolin-3-yl)butanoyl)piperazin-1-yl]benzamide
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C51H52N6O5S
 1
1
IC50 = 104 nM
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CP0770059
N-(4-(3-(5-Hydroxy-1H-benzo(d)imidazol-2-yl)-propanamido)butyl)-3-(4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamide
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C39H40N4O4
 1
1
IC50 = 107 nM
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CP0240379
(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]-N-[2-[[(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]prop-2-enoyl]amino]ethyl]prop-2-enamide
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C46H48N2O4
 1
1
IC50 = 131 nM
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CP0363564
(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]-N-[3-[[(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoyl]amino]propyl]prop-2-enamide
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C53H50N2O4
 1
1
IC50 = 136 nM
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CP0240381
(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]-N-[5-[[(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoyl]amino]pentyl]prop-2-enamide
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C55H54N2O4
 1
1
IC50 = 160 nM
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CP0040596
(E)-3-[4-[(E)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
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C25H22O3
 1
1
IC50 = 238 nM
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CP0690577
(E)-3-(4-((E/Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylic acid
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C25H22O3
 1
1
IC50 = 238 nM
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CP0240382
(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]-N-[2-[[(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoyl]amino]ethyl]prop-2-enamide
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C52H48N2O4
 1
1
IC50 = 260 nM
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CP0264515
(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]-N-[4-[[(E)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoyl]amino]butyl]prop-2-enamide
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C54H52N2O4
 1
1
IC50 = 290 nM
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CP0240378
(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]-N-[3-[[(E)-3-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenyl]prop-2-enoyl]amino]propyl]prop-2-enamide
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C47H50N2O4
 1
1
IC50 = 565 nM
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CP0943750
N-(3-(3-(4-((E/Z)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylamido)propyl)-4-(4-(8-(4-oxo-2-thioxodihydroquinazolin-3-yl)octanoyl)piperazin-1-yl)benzamide
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C55H60N6O5S
 1
1
IC50 = 914 nM
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