General Information of the Compound
Compound ID
CP0166061
Compound Name
2-(4-Hydroxy-phenyl)-1-(4-trifluoromethyl-phenyl)-3H-inden-5-ol
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Structure
Formula
C22H15F3O2
Molecular Weight
368.354
Canonical SMILES
Oc1ccc(cc1)C1=C(c2ccc(O)cc2C1)c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C22H15F3O2/c23-22(24,25)16-5-1-14(2-6-16)21-19-10-9-18(27)11-15(19)12-20(21)13-3-7-17(26)8-4-13/h1-11,26-27H,12H2
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InChIKey
ABWCAVMWLBXQQF-UHFFFAOYSA-N
Physicochemical Property
logP
5.6318
Rotatable Bonds
2
Heavy Atom Count
27
Polar Areas
40.46
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11696330
SID: 16800833
ChEMBL ID
CHEMBL197080
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00886, Estrogen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
EC50 = 15 nM
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