Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-Hydroxytamoxifen
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 PubChem ID
CID: 449459
SID: 14805025
Canonical SMILES
CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
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Compound Formula C26H29NO2
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 1
Uniprot ID
P03372
Gene Name
ESR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 0.79 nM
   TI
   LI
   LO
   TS
2
IC50 = 70 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 10.2 nM
   TI
   LI
   LO
   TS
CL000078 T-47D
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.36 nM
   TI
   LI
   LO
   TS
CL001063 T47D-KBluc
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.1 nM
2 IC50 = 2.24 nM
3 IC50 = 7.5 nM