Brief Information of the Cell Line and Protein
Cell Line ID: CL000040 , THP-1
 Cell Line Info 
Synonyms
THP1
THP 1
THPI
THP-1(ATCC)
THP-1-O
O-THP-1
Tohoku Hospital Pediatrics-1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0006
Protein ID: PT03976 , Proprotein convertase subtilisin/kexin type 9
 Protein Info 
Gene Name PCSK9
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID Q8NBP7
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000040
 Cell Line Info 
 Protein ID: PT03976
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0190058
 Compound Info 
US9227956, 16
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C22H20ClN7O
  1
1
IC50 = 750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0241695
 Compound Info 
US9227956, 3
   Show/Hide
C23H22ClN7O
  1
1
IC50 = 780 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0327557
 Compound Info 
N-(3-chloropyridin-2-yl)-4-(5-methyltriazolo[4,5-b]pyridin-3-yl)-N-[(3R)-piperidin-3-yl]benzamide
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C23H22ClN7O
  1
1
IC50 = 900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0073456
 Compound Info 
N-isoquinolin-1-yl-N-[(3R)-piperidin-3-yl]-4-pyrazolo[1,5-a]pyrimidin-3-ylbenzamide
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C27H24N6O
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496476
 Compound Info 
3-fluoro-4-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-methylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]benzamide
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C25H25FN6O
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0542450
 Compound Info 
US9227956, 1
   Show/Hide
C24H24N6O
  1
1
IC50 = 2200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0470137
 Compound Info 
US9227956, 13
   Show/Hide
C24H27N5O3
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0327533
 Compound Info 
N-(3-chloropyridin-2-yl)-4-(6-methylpyrazin-2-yl)-N-[(3R)-piperidin-3-yl]benzamide
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C22H22ClN5O
  1
1
IC50 = 2800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0073458
 Compound Info 
N-(3-chloropyridin-2-yl)-4-[6-(dimethylamino)pyrazin-2-yl]-N-[(3R)-piperidin-3-yl]benzamide
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C23H25ClN6O
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0073459
 Compound Info 
N-(3-chloropyridin-2-yl)-4-[6-(methylamino)pyrazin-2-yl]-N-[(3R)-piperidin-3-yl]benzamide
   Show/Hide
C22H23ClN6O
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS