Brief Information of the Compound and Protein
Compound Name
N-isoquinolin-1-yl-N-[(3R)-piperidin-3-yl]-4-pyrazolo[1,5-a]pyrimidin-3-ylbenzamide
    Show/Hide
PubChem ID
CID: 138544609
Canonical SMILES
O=C(N([C@@H]1CCCNC1)c1nccc2ccccc12)c1ccc(cc1)-c1cnn2cccnc12
    Show/Hide
Compound Formula C27H24N6O
Compound Structure
Protein Name
Proprotein convertase subtilisin/kexin type 9
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease SB clan
>
Serine protease S8A subfamily
Uniprot ID
Q8NBP7
Gene Name
PCSK9
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS