Brief Information of the Cell Line and Protein
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Synonyms
NIH/3T3
NIH-3T3
NIH3T3
3T3
3T3NIH
3T3-Swiss
Swiss-3T3
Swiss/3T3
Swiss 3T3
Swiss3T3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Protein ID: PT01411 , Fibroblast growth factor receptor 3
 Protein Info 
Gene Name FGFR3
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P22607
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000035
 Cell Line Info 
 Protein ID: PT01411
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0239886
 Compound Info 
2-methyl-6-(6-morpholin-4-yl-3H-imidazo[4,5-c]pyridin-2-yl)-7-[[(1S)-1-pyrimidin-2-ylethyl]amino]-4H-pyrazolo[4,3-b]pyridin-5-one
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C23H24N10O2
  2
1
IC50 = 5.896 nM
 Bioactivity Info 
   TI
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   TS
2
IC50 = 9.538 nM
 Bioactivity Info 
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CP0360944
 Compound Info 
6-(4-fluoro-6-morpholin-4-yl-1H-benzimidazol-2-yl)-2-methyl-7-[[(1S)-1-pyrimidin-2-ylethyl]amino]-4H-pyrazolo[4,3-b]pyridin-5-one
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C24H24FN9O2
  2
1
IC50 = 5.9 nM
 Bioactivity Info 
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2
IC50 = 6.96 nM
 Bioactivity Info 
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CP0543901
 Compound Info 
6-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-1H-benzimidazol-2-yl]-2-methyl-7-[[(1S)-1-pyrimidin-2-ylethyl]amino]-4H-pyrazolo[4,3-b]pyridin-5-one
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C26H29N9O2
  2
1
IC50 = 8.387 nM
 Bioactivity Info 
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2
IC50 = 11.14 nM
 Bioactivity Info 
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CP0143885
 Compound Info 
2-methyl-6-(6-methyl-5-morpholin-4-yl-1H-benzimidazol-2-yl)-7-[[(1S)-1-pyrimidin-2-ylpropyl]amino]-4H-pyrazolo[4,3-b]pyridin-5-one
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C26H29N9O2
  2
1
IC50 = 13.87 nM
 Bioactivity Info 
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2
IC50 = 17.41 nM
 Bioactivity Info 
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CP0426746
 Compound Info 
2-methyl-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-7-[[(1S)-2-methyl-1-pyridin-2-ylpropyl]amino]-4H-pyrazolo[4,3-b]pyridin-5-one
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C28H33N9O
  2
1
IC50 = 26.66 nM
 Bioactivity Info 
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2
IC50 = 29.14 nM
 Bioactivity Info 
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CP0455757
 Compound Info 
2-methyl-6-[5-morpholin-4-yl-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-7-[[(1R)-1-(1,3-oxazol-4-yl)ethyl]amino]-4H-pyrazolo[4,3-b]pyridin-5-one
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C24H23F3N8O3
  2
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
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2
IC50 = 10000 nM
 Bioactivity Info 
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