| Compound ID |
Compound Name |
Compound Formula |
|
CP0488419
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(3-bromophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24BrN5O5
|
1
|
| 1 |
EC50 = 0.1 nM
|
|
|
|
CP0488416
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(2-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27ClN6O5
|
1
|
| 1 |
EC50 = 0.123 nM
|
|
|
|
CP0494931
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-(3-methoxyphenoxy)cyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C24H30N6O6
|
1
|
| 1 |
EC50 = 0.1318 nM
|
|
|
|
CP0488423
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(3-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29BrN6O5
|
1
|
| 1 |
EC50 = 0.1413 nM
|
|
|
|
CP0488250
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(3-bromophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27BrN6O5
|
1
|
| 1 |
EC50 = 0.2399 nM
|
|
|
|
CP0495143
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-phenoxycyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C23H28N6O5
|
1
|
| 1 |
EC50 = 0.2951 nM
|
|
|
|
CP0488420
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-(3-methoxyphenoxy)cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C22H27N5O6
|
1
|
| 1 |
EC50 = 0.5248 nM
|
|
|
|
CP0488422
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(3-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27ClN6O5
|
1
|
| 1 |
EC50 = 0.5248 nM
|
|
|
|
CP0488244
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(3-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24ClN5O5
|
1
|
| 1 |
EC50 = 0.6166 nM
|
|
|
|
CP0488425
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(2-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24ClN5O5
|
1
|
| 1 |
EC50 = 0.9333 nM
|
|
|
|
CP0545475
|
4-(1-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-yl)morpholine
Show/Hide
|
C16H17N5O
|
1
|
| 1 |
EC50 = 0.9772 nM
|
|
|
|
CP0527804
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-phenoxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C21H25N5O5
|
1
|
| 1 |
EC50 = 1.047 nM
|
|
|
|
CP0039348
|
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C12H16N6O4
|
7
|
| 1 |
EC50 = 1.096 nM
|
|
|
| 2 |
EC50 = 1.82 nM
|
|
|
| 3 |
EC50 = 5.03 nM
|
|
|
| 4 |
IC50 = 0.2089 nM
|
|
|
| 5 |
IC50 = 1.122 nM
|
|
|
| 6 |
Ki = 83.18 nM
|
|
|
| 7 |
Ki = 5011.87 nM
|
|
|
|
CP0546942
|
4-(2-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-yl)morpholine
Show/Hide
|
C16H17N5O
|
1
|
| 1 |
EC50 = 1.096 nM
|
|
|
|
CP0569089
|
N-benzyl-2-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-amine
Show/Hide
|
C19H17N5
|
1
|
| 1 |
EC50 = 1.514 nM
|
|
|
|
CP0527802
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-[(3-methoxyphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C23H29N5O6
|
1
|
| 1 |
EC50 = 1.82 nM
|
|
|
|
CP0495145
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-[(3-methoxyphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C25H32N6O6
|
1
|
| 1 |
EC50 = 2.138 nM
|
|
|
|
CP0495148
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(2-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29ClN6O5
|
1
|
| 1 |
EC50 = 2.138 nM
|
|
|
|
CP0546925
|
N-benzyl-2-methyl-3-propan-2-ylpyrazolo[3,4-d]pyridazin-7-amine
Show/Hide
|
C16H19N5
|
1
|
| 1 |
EC50 = 2.399 nM
|
|
|
|
CP0546622
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(2-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26ClN5O5
|
1
|
| 1 |
EC50 = 3.388 nM
|
|
|
|
CP0381926
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-phenylmethoxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C22H27N5O5
|
2
|
| 1 |
EC50 = 3.715 nM
|
|
|
| 2 |
IC50 = 0.6761 nM
|
|
|
|
CP0488424
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(3-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29ClN6O5
|
1
|
| 1 |
EC50 = 5.129 nM
|
|
|
|
CP0570800
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(4-tert-butylphenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C26H35N5O5
|
1
|
| 1 |
EC50 = 6.31 nM
|
|
|
|
CP0488249
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(4-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24ClN5O5
|
1
|
| 1 |
EC50 = 6.457 nM
|
|
|
|
CP0575929
|
N-benzyl-1-methyl-3-propan-2-ylpyrazolo[3,4-d]pyridazin-7-amine
Show/Hide
|
C16H19N5
|
1
|
| 1 |
EC50 = 7.079 nM
|
|
|
|
CP0495164
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(4-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27ClN6O5
|
1
|
| 1 |
EC50 = 10.23 nM
|
|
|
|
CP0488246
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(4-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29BrN6O5
|
1
|
| 1 |
EC50 = 10.72 nM
|
|
|
|
CP0488415
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(3-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26ClN5O5
|
1
|
| 1 |
EC50 = 13.18 nM
|
|
|
|
CP0570799
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-[(4-propan-2-ylphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C25H33N5O5
|
1
|
| 1 |
EC50 = 13.49 nM
|
|
|
|
CP0534813
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(4-tert-butylphenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C27H36N6O5
|
1
|
| 1 |
EC50 = 15.49 nM
|
|
|
|
CP0488245
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(3-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26BrN5O5
|
1
|
| 1 |
EC50 = 18.2 nM
|
|
|
|
CP0495149
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(4-tert-butylphenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C25H33N5O5
|
1
|
| 1 |
EC50 = 18.2 nM
|
|
|
|
CP0576784
|
4-[[(1R,2R)-2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]cyclopentyl]oxymethyl]benzamide
Show/Hide
|
C23H28N6O6
|
1
|
| 1 |
EC50 = 19.5 nM
|
|
|
|
CP0537614
|
4-[[(1R,2R)-2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]cyclopentyl]oxymethyl]benzonitrile
Show/Hide
|
C23H26N6O5
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0488421
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(4-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26BrN5O5
|
1
|
| 1 |
EC50 = 40.74 nM
|
|
|
|
CP0039042
|
N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide
Show/Hide
|
C21H14ClN5O2
|
3
|
| 1 |
EC50 = 47.86 nM
|
|
|
| 2 |
IC50 = 47.86 nM
|
|
|
| 3 |
Ki = 51.29 nM
|
|
|
|
CP0001102
|
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C10H13N5O4
|
2
|
| 1 |
EC50 = 69.18 nM
|
|
|
| 2 |
IC50 = 2.344 nM
|
|
|
|
CP0550419
|
N-benzyl-1-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-amine
Show/Hide
|
C19H17N5
|
1
|
| 1 |
EC50 = 70.79 nM
|
|
|
|
CP0204638
|
(2R,3R,4S,5R)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H27N5O4
|
1
|
| 1 |
EC50 = 209 nM
|
|
|
|
CP0058033
|
1,3-dipropyl-8-cyclopentylxanthine
Show/Hide
|
C16H24N4O2
|
3
|
| 1 |
EC50 = 933.25 nM
|
|
|
| 2 |
Ki = 39.81 nM
|
|
|
| 3 |
Ki = 95 nM
|
|
|
|
CP0204631
|
1-[(1S,2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]-1,2,4-triazole-3-carboxamide
Show/Hide
|
C10H14N4O4
|
1
|
| 1 |
EC50 = 2460 nM
|
|
|
|
CP0388187
|
ethyl 3-(4-acetyloxyphenyl)-5-amino-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C17H15N3O5S
|
1
|
| 1 |
EC50 = 2500 nM
|
|
|
|
CP0188363
|
5-Amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-thieno[3,4-d]pyridazine-1-carboxylic acid
Show/Hide
|
C14H11N3O4S
|
1
|
| 1 |
EC50 = 2600 nM
|
|
|
|
CP0388150
|
ethyl 5-amino-4-oxo-3-[3-(trifluoromethyl)phenyl]thieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C16H12F3N3O3S
|
1
|
| 1 |
EC50 = 2700 nM
|
|
|
|
CP0440777
|
5-amino-3-methyl-N2-phenylthiophene-2,4-dicarboxamide
Show/Hide
|
C13H13N3O2S
|
1
|
| 1 |
EC50 = 3950 nM
|
|
|
|
CP0128830
|
ethyl 5-amino-3-(4-methoxyphenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C16H15N3O4S
|
1
|
| 1 |
EC50 = 4300 nM
|
|
|
|
CP0913842
|
2-Amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbohydrazide hydrochloride
Show/Hide
|
C9H15ClN4OS
|
1
|
| 1 |
EC50 = 4400 nM
|
|
|
|
CP0421241
|
ethyl 5-amino-4-oxo-3-[4-(trifluoromethylsulfonyloxy)phenyl]thieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C16H12F3N3O6S2
|
1
|
| 1 |
EC50 = 4900 nM
|
|
|
|
CP0290978
|
ethyl 5-amino-3-(3-chlorophenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C15H12ClN3O3S
|
2
|
| 1 |
EC50 = 5700 nM
|
|
|
| 2 |
Ki = 5.754 nM
|
|
|
|
CP0421242
|
ethyl 5-amino-3-(4-iodophenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C15H12IN3O3S
|
1
|
| 1 |
EC50 = 7100 nM
|
|
|
|
CP0455098
|
ethyl 5-amino-3-(4-hydroxyphenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C15H13N3O4S
|
1
|
| 1 |
EC50 = 7100 nM
|
|
|
|
CP0400364
|
(S)-Ethyl 2-amino-6-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
Show/Hide
|
C24H31N3O5S
|
2
|
| 1 |
EC50 = 7200 nM
|
|
|
| 2 |
Kd = 371.54 nM
|
|
|
|
CP0894178
|
2-Amino-6-benzyl-N'-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbohydrazide hydrochloride
Show/Hide
|
C21H23ClN4OS
|
1
|
| 1 |
EC50 = 7800 nM
|
|
|
|
CP0439053
|
(R)-Ethyl 2-amino-6-(2-(tert-butoxycarbonylamino)-3-(tritylthio)propanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
Show/Hide
|
C37H41N3O5S2
|
1
|
| 1 |
EC50 = 7900 nM
|
|
|
|
CP0374056
|
2-Amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid
Show/Hide
|
C15H16N2O2S
|
1
|
| 1 |
EC50 = 8000 nM
|
|
|
|
CP0440778
|
ethyl 5-amino-4-oxo-3-[4-(trifluoromethyl)phenyl]thieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C16H12F3N3O3S
|
1
|
| 1 |
EC50 = 8400 nM
|
|
|
|
CP0859054
|
2-Amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbohydrazide hydrochloride
Show/Hide
|
C15H19ClN4OS
|
1
|
| 1 |
EC50 = 8900 nM
|
|
|
|
CP0439029
|
(R)-Ethyl 2-amino-6-(2-(tert-butoxycarbonyl(methyl)-amino)-3-(4-chlorophenyl)propanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
Show/Hide
|
C25H32ClN3O5S
|
2
|
| 1 |
EC50 = 9100 nM
|
|
|
| 2 |
Kd = 1819.7 nM
|
|
|
|
CP0388188
|
ethyl 5-amino-3-(4-tert-butylphenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C19H21N3O3S
|
1
|
| 1 |
EC50 = 9750 nM
|
|
|
|
CP0357103
|
5-Amino-3,4-dihydro-4-oxo-3-phenyl-thieno[3,4-d]pyridazine-1-carboxylic acid
Show/Hide
|
C13H9N3O3S
|
1
|
| 1 |
EC50 = 9800 nM
|
|
|
|
CP0150581
|
ethyl 2-amino-6-benzyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
Show/Hide
|
C17H20N2O2S
|
1
|
| 1 |
EC50 = 10300 nM
|
|
|
|
CP0440779
|
(2-amino-4,5-dimethylthiophen-3-yl)(thiophen-2-yl)methanone
Show/Hide
|
C11H11NOS2
|
1
|
| 1 |
EC50 = 11200 nM
|
|
|
|
CP0894176
|
2-Amino-6-methyl-N'-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbohydrazide hydrochloride
Show/Hide
|
C15H19ClN4OS
|
1
|
| 1 |
EC50 = 11500 nM
|
|
|
|
CP0322932
|
2-Amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid
Show/Hide
|
C9H12N2O2S
|
1
|
| 1 |
EC50 = 11600 nM
|
|
|
|
CP0845396
|
Ethyl 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride
Show/Hide
|
C10H15ClN2O2S
|
1
|
| 1 |
EC50 = 11700 nM
|
|
|
|
CP0905509
|
2-Amino-N-benzyl-6-methyl-4,5,6,7-tetrahydrothieno-[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C16H20ClN3OS
|
1
|
| 1 |
EC50 = 12000 nM
|
|
|
|
CP0400359
|
2-Amino-6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid
Show/Hide
|
C13H18N2O4S
|
1
|
| 1 |
EC50 = 12100 nM
|
|
|
|
CP0430809
|
ethyl 5-amino-3-(4-nitrophenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C15H12N4O5S
|
1
|
| 1 |
EC50 = 13000 nM
|
|
|
|
CP0874874
|
2-Amino-N,6-dibenzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C22H24ClN3OS
|
1
|
| 1 |
EC50 = 13100 nM
|
|
|
|
CP0430868
|
6-tert-Butyl 3-ethyl 2-amino-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
Show/Hide
|
C15H22N2O4S
|
2
|
| 1 |
EC50 = 13200 nM
|
|
|
| 2 |
Kd = 831.76 nM
|
|
|
|
CP0879688
|
2-Amino-N-(3-chlorobenzyl)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C16H19Cl2N3OS
|
1
|
| 1 |
EC50 = 13200 nM
|
|
|
|
CP0044367
|
(2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluoromethyl-phenyl)-methanone
Show/Hide
|
C14H12F3NOS
|
1
|
| 1 |
EC50 = 13600 nM
|
|
|
|
CP0209670
|
ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate
Show/Hide
|
C15H13N3O3S
|
1
|
| 1 |
EC50 = 13600 nM
|
|
|
|
CP0459064
|
2-Amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile
Show/Hide
|
C15H15N3S
|
1
|
| 1 |
EC50 = 15200 nM
|
|
|
|
CP0868050
|
2-Amino-6-benzyl-N-(3-(trifluoromethyl)benzyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C23H23ClF3N3OS
|
1
|
| 1 |
EC50 = 15500 nM
|
|
|
|
CP0400366
|
ethyl 2-amino-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
Show/Hide
|
C11H16N2O2S
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0439030
|
2-Amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile
Show/Hide
|
C9H11N3S
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0477327
|
tert-butyl 2-amino-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridine-6-carboxylate
Show/Hide
|
C13H17N3O2S
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0479742
|
(2-Amino-6-benzyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-3-yl)-(4-chloro-phenyl)-methanone
Show/Hide
|
C21H19ClN2OS
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0859053
|
2-Amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C15H18ClN3OS
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0868049
|
2-Amino-6-benzyl-N-(3-chlorobenzyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C22H23Cl2N3OS
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0874873
|
2-Amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
Show/Hide
|
C9H14ClN3OS
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0397955
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-phenylmethoxycyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C24H30N6O5
|
1
|
| 1 |
IC50 = 0.02951 nM
|
|
|
|
CP0385911
|
(2S,3S,4R,5R)-5-[6-(2-adamantylamino)purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C22H30N6O4
|
1
|
| 1 |
IC50 = 0.3981 nM
|
|
|
|
CP0077413
|
(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C15H20ClN5O4
|
1
|
| 1 |
IC50 = 0.5012 nM
|
|
|
|
CP0537775
|
1-[7-(cyclohexylamino)-1-methylpyrazolo[3,4-c]pyridin-3-yl]-3-phenylurea
Show/Hide
|
C20H24N6O
|
2
|
| 1 |
IC50 = 1.413 nM
|
|
|
| 2 |
Ki = 1000 nM
|
|
|
|
CP0543064
|
3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C21H20N4O3
|
2
|
| 1 |
IC50 = 1.905 nM
|
|
|
| 2 |
Ki = 165.96 nM
|
|
|
|
CP0551633
|
2-anilino-N-(5-anilino-1-methylpyrazolo[3,4-c]pyridin-3-yl)acetamide
Show/Hide
|
C21H20N6O
|
2
|
| 1 |
IC50 = 2.63 nM
|
|
|
| 2 |
Ki = 295.12 nM
|
|
|
|
CP0385491
|
(2S,3S,4R,5R)-5-[6-(1-adamantylamino)purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C22H30N6O4
|
1
|
| 1 |
IC50 = 2.884 nM
|
|
|
|
CP0537767
|
5-chloro-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C21H19ClN4O3
|
2
|
| 1 |
IC50 = 2.884 nM
|
|
|
| 2 |
Ki = 218.78 nM
|
|
|
|
CP0544747
|
3-propan-2-yl-7-(3,4,5-trimethoxyanilino)-2H-pyrazolo[3,4-c]pyridine-5-carbonitrile
Show/Hide
|
C19H21N5O3
|
2
|
| 1 |
IC50 = 3.236 nM
|
|
|
| 2 |
Ki = 12.3 nM
|
|
|
|
CP0546190
|
5-[(benzylamino)methyl]-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C29H29N5O3
|
2
|
| 1 |
IC50 = 3.89 nM
|
|
|
| 2 |
Ki = 204.17 nM
|
|
|
|
CP0381923
|
(2R,3R,4S,5R)-2-[6-((1R,2R)-2-Hydroxy-cyclopentylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C15H21N5O5
|
1
|
| 1 |
IC50 = 4.365 nM
|
|
|
|
CP0546210
|
5-[[(1-methylpiperidin-4-yl)methylamino]methyl]-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C29H36N6O3
|
2
|
| 1 |
IC50 = 4.677 nM
|
|
|
| 2 |
Ki = 741.31 nM
|
|
|
|
CP0543596
|
5-chloro-3-propan-2-yl-N-(3,4,5-trimethoxyphenyl)-2H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C18H21ClN4O3
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
Ki = 288.4 nM
|
|
|
|
CP0546208
|
N-(5-anilino-1-methylpyrazolo[3,4-c]pyridin-3-yl)benzamide
Show/Hide
|
C20H17N5O
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
Ki > 954.99 nM
|
|
|
|
CP0385928
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-hydroxycyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C17H24N6O5
|
1
|
| 1 |
IC50 = 6.166 nM
|
|
|
|
CP0546191
|
2-anilino-N-(5-anilino-1H-pyrazolo[3,4-c]pyridin-3-yl)acetamide
Show/Hide
|
C20H18N6O
|
2
|
| 1 |
IC50 = 6.918 nM
|
|
|
| 2 |
Ki = 363.08 nM
|
|
|
|
CP0550409
|
7-(3,4,5-trimethoxyanilino)-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile
Show/Hide
|
C16H15N5O3
|
2
|
| 1 |
IC50 = 10.23 nM
|
|
|
| 2 |
Ki = 229.09 nM
|
|
|
|
CP0537770
|
3-phenyl-5-[(pyridin-3-ylmethylamino)methyl]-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C28H28N6O3
|
2
|
| 1 |
IC50 = 12.02 nM
|
|
|
| 2 |
Ki = 58.88 nM
|
|
|
|
CP0544746
|
7-anilino-3-phenyl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile
Show/Hide
|
C19H13N5
|
2
|
| 1 |
IC50 = 13.49 nM
|
|
|
| 2 |
Ki = 213.8 nM
|
|
|
|
CP0375806
|
(2R,3R,4S,5R)-2-[6-(1-adamantylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H27N5O4
|
1
|
| 1 |
IC50 = 19.05 nM
|
|
|
|
CP0544745
|
5-(aminomethyl)-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C22H23N5O3
|
2
|
| 1 |
IC50 = 22.91 nM
|
|
|
| 2 |
Ki = 22.91 nM
|
|
|
|
CP0381922
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(3-hydroxy-1-adamantyl)amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C22H30N6O5
|
1
|
| 1 |
IC50 = 37.15 nM
|
|
|
|
CP0543063
|
3-phenyl-7-(3,4,5-trimethoxyanilino)-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile
Show/Hide
|
C22H19N5O3
|
2
|
| 1 |
IC50 = 199.53 nM
|
|
|
| 2 |
Ki = 4.365 nM
|
|
|
|
CP0483161
|
2-amino-4-(1,3-benzodioxol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Show/Hide
|
C17H15N3O2
|
1
|
| 1 |
IC50 = 416.87 nM
|
|
|
|
CP0384080
|
2-amino-4-(3-bromophenyl)-6-(4-methoxyphenyl)pyridine-3-carbonitrile
Show/Hide
|
C19H14BrN3O
|
1
|
| 1 |
IC50 = 1258.93 nM
|
|
|
|
CP0059859
|
1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione
Show/Hide
|
C13H12N4O2
|
1
|
| 1 |
IC50 = 1340 nM
|
|
|
|
CP0478441
|
N-cyclopentyl-5-methyl-3-[(4-methylbenzoyl)amino]-1H-indole-2-carboxamide
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
IC50 = 1479.11 nM
|
|
|
|
CP0468872
|
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-3H-pyrido[2,3-d]pyrimidin-4-one
Show/Hide
|
C17H15ClN4O
|
1
|
| 1 |
IC50 = 1862.09 nM
|
|
|
|
CP0521358
|
2-(3-cyclopropyl-4-oxo-7-phenylpyrrolo[3,2-d]pyrimidin-5-yl)-N-[(4-fluorophenyl)methyl]acetamide
Show/Hide
|
C24H21FN4O2
|
1
|
| 1 |
IC50 = 2818.38 nM
|
|
|
|
CP0548760
|
3-prop-2-enyl-2-(pyridin-2-ylmethylsulfanyl)-5H-pyrimido[5,4-b]indol-4-one
Show/Hide
|
C19H16N4OS
|
1
|
| 1 |
IC50 = 7943.28 nM
|
|
|
|
CP0955447
|
(1r,4r)-4-(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol
Show/Hide
|
C18H20N4O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0518452
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(2E,4E)-deca-2,4-dienylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H29N7O4
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0475464
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-morpholin-4-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H26N8O5
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0562184
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(6-methoxypyridin-3-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C17H20N8O5
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0477485
|
2-[(E)-[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hydrazinylidene]methyl]benzonitrile
Show/Hide
|
C18H18N8O4
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0489544
|
4-[(E)-[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hydrazinylidene]methyl]benzonitrile
Show/Hide
|
C18H18N8O4
|
1
|
| 1 |
Ki = 4.1 nM
|
|
|
|
CP0444811
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[5-(4-bromophenyl)furan-2-yl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H20BrN7O5
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0533208
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(2-chloropyridin-3-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C16H17ClN8O4
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0444812
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(5-bromopyridin-2-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C16H17BrN8O4
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0538071
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-pyrrolidin-1-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H26N8O4
|
1
|
| 1 |
Ki = 5.1 nM
|
|
|
|
CP0523174
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(cyclopentylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C16H23N7O4
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0424774
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic Acid (2-dimethylamino-ethyl)-amide
Show/Hide
|
C24H38N6O3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0137617
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-1-[[3-(trifluoromethyl)phenyl]methyl]pyrazole-4-carboxamide
Show/Hide
|
C24H22F3N5O3S
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0398047
|
(R)-N-(2-hydroxy-1-phenylethyl)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)acetamide
Show/Hide
|
C30H27N3O4S
|
1
|
| 1 |
Ki = 6.1 nM
|
|
|
|
CP0499917
|
3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-propionic acid
Show/Hide
|
C22H32N4O4
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0386543
|
3-noradamantyl-1,3-dipropylxanthine
Show/Hide
|
C20H28N4O2
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0441857
|
CHEMBL424908
Show/Hide
|
C23H33N5O5
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0489545
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(1H-pyrrol-2-ylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C15H18N8O4
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0386036
|
(S)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylpropyl)acetamide
Show/Hide
|
C31H29N3O3S
|
1
|
| 1 |
Ki = 8.6 nM
|
|
|
|
CP0408622
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester
Show/Hide
|
C21H30N4O4
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0388260
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-1-[(3-fluorophenyl)methyl]pyrazole-4-carboxamide
Show/Hide
|
C23H22FN5O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0386541
|
(E)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-acrylic acid
Show/Hide
|
C22H30N4O4
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0520198
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(quinolin-6-ylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H20N8O4
|
1
|
| 1 |
Ki = 9.8 nM
|
|
|
|
CP0408804
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexanecarboxylic acid (2-dimethylamino-ethyl)-amide
Show/Hide
|
C22H36N6O3
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0428069
|
1,3-dipropyl-8-[2-(5,6-exo-epoxy-(1S,2S)-norborn-2-yl)]-xanthine
Show/Hide
|
C18H24N4O3
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0386041
|
2-(3-(3-methylisoxazol-5-yl)-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C32H31N3O4
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0435782
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(2-butyl-5-chloro-1H-imidazol-4-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C18H24ClN9O4
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0374990
|
2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylcyclopropyl)acetamide
Show/Hide
|
C31H27N3O3S
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0444809
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3-phenylmethoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C24H25N7O5
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0497001
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0408621
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbaldehyde
Show/Hide
|
C20H28N4O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0398046
|
(S)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylethyl)acetamide
Show/Hide
|
C30H27N3O3S
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0518089
|
8-(4-hydroxymethyl-bicyclo[2.2.2]oct-1-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C20H30N4O3
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0378950
|
3-[4-amino-6-[(2-fluorophenyl)methyl]thieno[2,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C20H13FN4S
|
1
|
| 1 |
Ki < 16 nM
|
|
|
|
CP0467093
|
6-[(2-fluorophenyl)methyl]-2-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H14FN3OS
|
1
|
| 1 |
Ki < 16 nM
|
|
|
|
CP0168163
|
(E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0408214
|
1-[6-Amino-8-(2-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0447642
|
2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C31H29N3O3S
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0377249
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclopentanol
Show/Hide
|
C19H18FN5O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0428185
|
3-{[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbonyl]-amino}-propionic acid methy lester
Show/Hide
|
C24H35N5O5
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0537946
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(1,3-thiazol-5-ylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C14H16N8O4S
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0406021
|
methyl 2-[acetyl-[2-[(4-fluorobenzoyl)amino]-4-methoxy-1,3-benzothiazol-7-yl]amino]acetate
Show/Hide
|
C20H18FN3O5S
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0439129
|
3-[4-amino-6-[(2-chlorophenyl)methyl]thieno[2,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C20H13ClN4S
|
1
|
| 1 |
Ki = 24.8 nM
|
|
|
|
CP0462263
|
1-(6-Amino-8-furan-2-yl-9-methyl-9H-purin-2-ylethynyl)-cyclohexanol
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0467091
|
6-[(2-chlorophenyl)methyl]-2-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H14ClN3OS
|
1
|
| 1 |
Ki = 26.1 nM
|
|
|
|
CP0422751
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cycloheptanol
Show/Hide
|
C21H22FN5O
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0124553
|
4-[6-amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-ol
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
Ki = 27 nM
|
|
|
| 2 |
Ki = 34 nM
|
|
|
|
CP0498601
|
6-[(2-fluorophenyl)methyl]-2-(4-methyl-1,3-thiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H13FN4S2
|
1
|
| 1 |
Ki = 28.6 nM
|
|
|
|
CP0383165
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-yl]-3-ethyl-pent-1-yn-3-ol
Show/Hide
|
C19H20FN5O
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0408620
|
4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-butyric acid
Show/Hide
|
C23H34N4O4
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0377242
|
4-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-yl]-2-methyl-but-3-yn-2-ol
Show/Hide
|
C17H16FN5O
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0377191
|
N-[7-[acetyl(difluoromethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-fluorobenzamide
Show/Hide
|
C18H14F3N3O3S
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0377192
|
N-[7-[acetyl(ethyl)amino]-4-chloro-1,3-benzothiazol-2-yl]-4-fluorobenzamide
Show/Hide
|
C18H15ClFN3O2S
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0495994
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic acid
Show/Hide
|
C20H28N4O4
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0404529
|
US9133197, 4
Show/Hide
|
C12H16N8O
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0377196
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-1H-pyrrole-3-carboxamide
Show/Hide
|
C17H18N4O3S
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0406020
|
4-fluoro-N-(7-(N-isobutylacetamido)-4-methoxybenzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C21H22FN3O3S
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0482303
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-(trifluoromethyl)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C18H18F3N7O4
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0880224
|
2-(5-bromofuran-2-yl)-6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H21BrN4OS
|
1
|
| 1 |
Ki = 40.2 nM
|
|
|
|
CP0419617
|
8-(4-hydroxymethyl-cyclohexyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C18H28N4O3
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0439004
|
4-fluoro-N-(4-methoxy-7-(N-(2,2,2-trifluoroethyl)acetamido)benzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C19H15F4N3O3S
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0467673
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexanecarboxylic acid butylamide
Show/Hide
|
C22H35N5O3
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0408623
|
2-[[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)bicyclo[2.2.2]octane-1-carbonyl]amino]acetic acid
Show/Hide
|
C22H31N5O5
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0396328
|
6-[(2-chlorophenyl)methyl]-2-(4-methyl-1,3-thiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H13ClN4S2
|
1
|
| 1 |
Ki = 49.6 nM
|
|
|
|
CP0417790
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-(pyrrolidine-1-carbonyl)benzamide
Show/Hide
|
C24H26N4O4S
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0101857
|
US9133197, 1
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
Ki = 51 nM
|
|
|
| 2 |
Ki = 150 nM
|
|
|
|
CP0397724
|
US9133197, 3
Show/Hide
|
C12H16N8O
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0371895
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-fluorobenzamide
Show/Hide
|
C19H18FN3O3S
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0377190
|
4-fluoro-N-(4-methoxy-7-(N-methylacetamido)benzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C18H16FN3O3S
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0386033
|
1-benzyl-3-((2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yl)methyl)urea
Show/Hide
|
C29H26N4O2S
|
1
|
| 1 |
Ki = 68 nM
|
|
|
|
CP0501666
|
1-((2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yl)methyl)-3-(2-phenylpropan-2-yl)urea
Show/Hide
|
C31H30N4O2S
|
1
|
| 1 |
Ki = 68 nM
|
|
|
|
CP0455803
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-[(4-fluorophenyl)methoxy]phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C24H24FN7O5
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0454301
|
4-cyano-N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C20H18N4O3S
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0371897
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-pyrazol-1-ylbenzamide
Show/Hide
|
C22H21N5O3S
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0497573
|
6-benzyl-2-pyrazin-2-ylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H13N5S
|
1
|
| 1 |
Ki = 91 nM
|
|
|
|
CP0386542
|
1-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbonyl]-piperidine-4-carboxylic acid
Show/Hide
|
C26H37N5O5
|
1
|
| 1 |
Ki = 96 nM
|
|
|
|
CP0164878
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-2-methylpyrazole-3-carboxamide
Show/Hide
|
C17H19N5O3S
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0438989
|
4-fluoro-N-(7-(N-(3-hydroxypropyl)acetamido)-4-methoxybenzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C20H20FN3O4S
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0028721
|
2-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C12H16N8
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0095767
|
6-[[(2S,6R)-2,6-dimethylpiperidin-1-yl]methyl]-2-(furan-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H22N4OS
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0380534
|
N-benzyl-2-[[2-oxo-4-(2-phenylethyl)-3-(1,3-thiazol-2-yl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C29H25N3O3S
|
1
|
| 1 |
Ki = 101 nM
|
|
|
|
CP0523778
|
6-benzyl-2-(1,3-oxazol-5-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C16H12N4OS
|
1
|
| 1 |
Ki = 106 nM
|
|
|
|
CP0441852
|
benzyl N-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)cyclohexyl]carbamate
Show/Hide
|
C25H33N5O4
|
1
|
| 1 |
Ki = 109 nM
|
|
|
|
CP0377195
|
4-fluoro-N-(4-methoxy-7-(N-(2-methoxyethyl)acetamido)benzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C20H20FN3O4S
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0439007
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-(methanesulfonamido)benzamide
Show/Hide
|
C20H22N4O5S2
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0495993
|
2-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl)(methyl)amino)acetic acid
Show/Hide
|
C24H35N5O5
|
1
|
| 1 |
Ki = 112 nM
|
|
|
|
CP0472457
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-(4-methylpiperazine-1-carbonyl)benzamide
Show/Hide
|
C25H29N5O4S
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0214627
|
US9133197, 5
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
Ki = 120 nM
|
|
|
| 2 |
Ki = 160 nM
|
|
|
|
CP0378960
|
6-[(2-methoxyphenyl)methyl]-2-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H17N3O2S
|
1
|
| 1 |
Ki = 122 nM
|
|
|
|
CP0467090
|
6-benzyl-2-(3-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H14FN3S
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0409950
|
3-[4-amino-6-[(2-methoxyphenyl)methyl]thieno[2,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C21H16N4OS
|
1
|
| 1 |
Ki = 129 nM
|
|
|
|
CP0402364
|
3-[6-Amino-2-(1-hydroxy-cyclohexylethynyl)-9-methyl-9H-purin-8-yl]-benzonitrile
Show/Hide
|
C21H20N6O
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0438976
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-(tetrazol-1-yl)benzamide
Show/Hide
|
C20H19N7O3S
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0867276
|
3-(4-amino-6-pyrrolidin-1-ylmethyl-thieno[2,3-d]-pyrimidin-2-yl)-benzonitrile
Show/Hide
|
C18H17N5S
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0959023
|
6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)-2-(5-isopropylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C21H28N4OS
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0425918
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-imidazol-1-ylbenzamide
Show/Hide
|
C22H21N5O3S
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0853657
|
6-(3,6-dihydro-2H-pyridin-1-ylmethyl)-2-furan-2-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H16N4OS
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0381547
|
6-benzyl-2-phenylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H15N3S
|
1
|
| 1 |
Ki = 151 nM
|
|
|
|
CP0506091
|
N-benzyl-2-[1-methyl-3-methylsulfonyl-2-oxo-4-(2-phenylethyl)quinolin-6-yl]oxyacetamide
Show/Hide
|
C28H28N2O5S
|
1
|
| 1 |
Ki = 159 nM
|
|
|
|
CP0472455
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-(morpholine-4-carbonyl)benzamide
Show/Hide
|
C24H26N4O5S
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0386039
|
(R)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylethyl)acetamide
Show/Hide
|
C30H27N3O3S
|
1
|
| 1 |
Ki = 170 nM
|
|
|
|
CP0408805
|
8-(4-benzyloxymethyl-cyclohexyl)-1,3-dipropyl-3,7-dihydropurine-2,6-dione
Show/Hide
|
C25H34N4O3
|
1
|
| 1 |
Ki = 171 nM
|
|
|
|
CP0472456
|
1-N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-N-(2-methoxyethyl)-4-N-methylbenzene-1,4-dicarboxamide
Show/Hide
|
C24H28N4O5S
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0374991
|
2-(2-oxo-4-(phenoxymethyl)-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C30H27N3O4S
|
1
|
| 1 |
Ki = 183 nM
|
|
|
|
CP0436824
|
methyl 4-[[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]carbamoyl]benzoate
Show/Hide
|
C21H21N3O5S
|
1
|
| 1 |
Ki = 185 nM
|
|
|
|
CP0438977
|
4-N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-1-N-methylbenzene-1,4-dicarboxamide
Show/Hide
|
C21H22N4O4S
|
1
|
| 1 |
Ki = 185 nM
|
|
|
|
CP0375733
|
6-[(2-methoxyphenyl)methyl]-2-(4-methyl-1,3-thiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H16N4OS2
|
1
|
| 1 |
Ki = 186 nM
|
|
|
|
CP0864794
|
2-(5-chloro-furan-2-yl)-6-(3,3-difluoro-piperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H15ClF2N4OS
|
1
|
| 1 |
Ki = 188 nM
|
|
|
|
CP0849517
|
2-(5-chloro-furan-2-yl)-6-(3,6-dihydro-2Hpyridin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H15ClN4OS
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0849518
|
6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)-2-(5-ethylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C20H26N4OS
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0056974
|
4-[6-amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-one
Show/Hide
|
C12H14N8O
|
2
|
| 1 |
Ki = 197 nM
|
|
|
| 2 |
Ki = 200 nM
|
|
|
|
CP0514725
|
2-(cyclopropylamino)-7-(2-fluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
Ki = 201 nM
|
|
|
|
CP0850770
|
3-[4-amino-6-(3,6-dihydro-2H-pyridin-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C19H17N5S
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0481153
|
US9133197, 6
Show/Hide
|
C12H14N8O
|
1
|
| 1 |
Ki = 216 nM
|
|
|
|
CP0439130
|
3-(4-amino-6-benzylthieno[2,3-d]pyrimidin-2-yl)benzonitrile
Show/Hide
|
C20H14N4S
|
1
|
| 1 |
Ki = 222 nM
|
|
|
|
CP0381548
|
6-benzyl-2-(5-ethylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H17N3OS
|
1
|
| 1 |
Ki = 223 nM
|
|
|
|
CP0474791
|
2-(cyclopropylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H19F2N5O2
|
1
|
| 1 |
Ki = 236 nM
|
|
|
|
CP0556758
|
2,6-diphenylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H13N3S
|
1
|
| 1 |
Ki = 237 nM
|
|
|
|
CP0850771
|
2-(5-chloro-furan-2-yl)-6-(3,3-difluoro-pyrrolidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H13ClF2N4OS
|
1
|
| 1 |
Ki = 245 nM
|
|
|
|
CP0467089
|
6-benzyl-2-(2-methyl-1,3-thiazol-4-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H14N4S2
|
1
|
| 1 |
Ki = 263 nM
|
|
|
|
CP0409951
|
6-benzyl-2-(3-methoxyphenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C20H17N3OS
|
1
|
| 1 |
Ki = 266 nM
|
|
|
|
CP0498600
|
6-benzyl-2-(5-propan-2-ylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C20H19N3OS
|
1
|
| 1 |
Ki = 283 nM
|
|
|
|
CP0119411
|
6-[(3,3-difluoropiperidin-1-yl)methyl]-2-(furan-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C16H16F2N4OS
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0946683
|
6-((2,5-dihydro-1H-pyrrol-1-yl)methyl)-2-(furan-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C15H14N4OS
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0409949
|
6-benzyl-2-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H15N3OS
|
1
|
| 1 |
Ki = 298 nM
|
|
|
|
CP0371900
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-(piperidine-1-carbonyl)benzamide
Show/Hide
|
C25H28N4O4S
|
1
|
| 1 |
Ki = 300 nM
|
|
|
|
CP0849560
|
6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)-2-(4-methylthiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H23N5S2
|
1
|
| 1 |
Ki = 300 nM
|
|
|
|
CP0409948
|
6-benzyl-2-(1,3-oxazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C16H12N4OS
|
1
|
| 1 |
Ki = 310 nM
|
|
|
|
CP0509963
|
2-(cyclopropylamino)-7-(2-fluoro-6-methoxybenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H22FN5O3
|
1
|
| 1 |
Ki = 330 nM
|
|
|
|
CP0898627
|
2-(5-cyclopropylfuran-2-yl)-6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C21H26N4OS
|
1
|
| 1 |
Ki = 330 nM
|
|
|
|
CP0864803
|
2-(furan-2-yl)-6-(thiomorpholinomethyl)thieno-[2,3-d]pyrimidin-4-amine
Show/Hide
|
C15H16N4OS2
|
1
|
| 1 |
Ki = 369 nM
|
|
|
|
CP0380532
|
2-(2-oxo-4-phenethyl-3-(pyridin-4-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C33H31N3O3
|
1
|
| 1 |
Ki = 377 nM
|
|
|
|
CP0438975
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-methylsulfonylbenzamide
Show/Hide
|
C20H21N3O5S2
|
1
|
| 1 |
Ki = 390 nM
|
|
|
|
CP0475417
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-[(2-oxopyrrolidin-1-yl)methyl]benzamide
Show/Hide
|
C24H26N4O4S
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0386671
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
Ki = 402 nM
|
|
|
|
CP0436825
|
N-[7-[acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-[[methyl(methylsulfonyl)amino]methyl]benzamide
Show/Hide
|
C22H26N4O5S2
|
1
|
| 1 |
Ki = 410 nM
|
|
|
|
CP0386032
|
N-benzyl-2-[[3-(furan-2-yl)-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C30H26N2O4
|
1
|
| 1 |
Ki = 436 nM
|
|
|
|
CP0378959
|
2-(5-methylfuran-2-yl)-6-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H17N3OS
|
1
|
| 1 |
Ki = 439 nM
|
|
|
|
CP0440678
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-phenyl-7H-purin-8(9H)-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
Ki = 447 nM
|
|
|
|
CP0377194
|
4-fluoro-N-(7-(N-(2-hydroxyethyl)acetamido)-4-methoxybenzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C19H18FN3O4S
|
1
|
| 1 |
Ki = 450 nM
|
|
|
|
CP0849556
|
3-(4-amino-6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)thieno[2,3-d]pyrimidin-2-yl)benzonitrile
Show/Hide
|
C21H23N5S
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0409953
|
2-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C11H9N3OS
|
1
|
| 1 |
Ki = 493 nM
|
|
|
|
CP0496617
|
2-(2-oxo-4-phenethyl-3-(pyridin-3-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C33H31N3O3
|
1
|
| 1 |
Ki = 497 nM
|
|
|
|
CP0576118
|
4-(fluoromethyl)-4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C19H25FN4O4S
|
1
|
| 1 |
Ki = 497 nM
|
|
|
|
CP0860171
|
6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)-2-(isoxazol-3-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H21N5OS
|
1
|
| 1 |
Ki = 500 nM
|
|
|
|
CP0467092
|
2-[5-(difluoromethyl)furan-2-yl]-6-[(2-methoxyphenyl)methyl]thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H15F2N3O2S
|
1
|
| 1 |
Ki = 516 nM
|
|
|
|
CP0397691
|
2-(5-methylfuran-2-yl)-6-phenylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H13N3OS
|
1
|
| 1 |
Ki = 520 nM
|
|
|
|
CP0053494
|
4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol
Show/Hide
|
C16H15N7O2
|
1
|
| 1 |
Ki = 540 nM
|
|
|
|
CP0371893
|
N-[7-[acetyl-(2-amino-2-oxoethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-fluorobenzamide
Show/Hide
|
C19H17FN4O4S
|
1
|
| 1 |
Ki = 560 nM
|
|
|
|
CP0522424
|
7-benzyl-2-(cyclopropylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
Ki = 564 nM
|
|
|
|
CP0560179
|
N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-3,6-dihydro-2H-pyridine-1-carboxamide
Show/Hide
|
C18H22N4O3S
|
1
|
| 1 |
Ki = 577 nM
|
|
|
|
CP0559950
|
4-fluoro-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C18H23FN4O3S
|
1
|
| 1 |
Ki = 591 nM
|
|
|
|
CP0522817
|
2-(cyclopropylamino)-9-(3-fluorophenyl)-7-(2-methoxybenzyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
Ki = 599 nM
|
|
|
|
CP0374988
|
N-[(3,4-dichlorophenyl)methyl]-N-methyl-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C28H26Cl2N2O5S
|
1
|
| 1 |
Ki = 602 nM
|
|
|
|
CP0880225
|
2-(5-methyl-furan-2-yl)-6-piperidin-1-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H20N4OS
|
1
|
| 1 |
Ki = 610 nM
|
|
|
|
CP0522422
|
7-(2,6-difluorobenzyl)-2-(isopropylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21F2N5O2
|
1
|
| 1 |
Ki = 616 nM
|
|
|
|
CP0381544
|
6-benzyl-2-pyrimidin-2-ylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H13N5S
|
1
|
| 1 |
Ki = 618 nM
|
|
|
|
CP0849558
|
2-(3-fluoro-phenyl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H17FN4OS
|
1
|
| 1 |
Ki = 620 nM
|
|
|
|
CP0958450
|
2-(5-methyl-furan-2-yl)-6-pyrrolidin-1-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H18N4OS
|
1
|
| 1 |
Ki = 620 nM
|
|
|
|
CP0856397
|
2-benzofuran-2-yl-6-(4-fluoropiperdin-1-ylmethyl)thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C20H19FN4OS
|
1
|
| 1 |
Ki = 630 nM
|
|
|
|
CP0898592
|
2-(5-chloro-furan-2-yl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H15ClN4O2S
|
1
|
| 1 |
Ki = 640 nM
|
|
|
|
CP0946687
|
2-isoxazol-3-yl-6-morpholin-4-ylmethyl-thieno-[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C14H15N5O2S
|
1
|
| 1 |
Ki = 680 nM
|
|
|
|
CP0853658
|
2-(5-bromo-furan-2-yl)-6-pyrrolidin-1-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H15BrN4OS
|
1
|
| 1 |
Ki = 710 nM
|
|
|
|
CP0881302
|
2-(5-chloro-furan-2-yl)-6-pyrrolidin-1-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H15ClN4OS
|
1
|
| 1 |
Ki = 710 nM
|
|
|
|
CP0849562
|
2-(5-bromo-furan-2-yl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H15BrN4O2S
|
1
|
| 1 |
Ki = 725 nM
|
|
|
|
CP0898624
|
2-(5-(difluoromethyl)furan-2-yl)-6-(((2R,6S)-2,6-dimethylpiperidin-1-yl)methyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H22F2N4OS
|
1
|
| 1 |
Ki = 730 nM
|
|
|
|
CP0901909
|
6-(4-fluoro-piperidin-1-ylmethyl)-2-furan-2-ylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H17FN4OS
|
1
|
| 1 |
Ki = 740 nM
|
|
|
|
CP0877428
|
2-(5-chloro-furan-2-yl)-6-(2,5-dihydro-pyrrol-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H13ClN4OS
|
1
|
| 1 |
Ki = 780 nM
|
|
|
|
CP0438988
|
4-fluoro-N-(4-methoxy-7-(N-(2-(methylamino)-2-oxoethyl)acetamido)benzo[d]thiazol-2-yl)benzamide
Show/Hide
|
C20H19FN4O4S
|
1
|
| 1 |
Ki = 790 nM
|
|
|
|
CP0881303
|
2-(3-chloro-phenyl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H17ClN4OS
|
1
|
| 1 |
Ki = 790 nM
|
|
|
|
CP0508092
|
8-[3-(2-Dimethylaminoethoxy)phenyl]-1,3-dimethylxanthine
Show/Hide
|
C17H21N5O3
|
1
|
| 1 |
Ki = 800 nM
|
|
|
|
CP0380536
|
N-[(3,4-dichlorophenyl)methyl]-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C27H24Cl2N2O5S
|
1
|
| 1 |
Ki = 811 nM
|
|
|
|
CP0467088
|
6-benzyl-2-pyridin-4-ylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H14N4S
|
1
|
| 1 |
Ki = 812 nM
|
|
|
|
CP0880227
|
3-[4-amino-6-(3,3-difluoro-piperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C19H17F2N5S
|
1
|
| 1 |
Ki = 840 nM
|
|
|
|
CP0397690
|
6-benzyl-2-(5-cyclopropylfuran-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C20H17N3OS
|
1
|
| 1 |
Ki = 861 nM
|
|
|
|
CP0856398
|
3-(4-amino-6-thiomorpholin-4-ylmethyl-thieno-[2,3-d]pyrimidin-2-yl)-benzonitrile
Show/Hide
|
C18H17N5S2
|
1
|
| 1 |
Ki = 980 nM
|
|
|
|
CP0849564
|
3-(4-amino-6-morpholin-4-ylmethyl-thieno[2,3-d]-pyrimidin-2-yl)-benzonitrile
Show/Hide
|
C18H17N5OS
|
1
|
| 1 |
Ki = 1010 nM
|
|
|
|
CP0901910
|
6-morpholin-4-ylmethyl-2-thiophen-2-yl-thieno-[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H16N4OS2
|
1
|
| 1 |
Ki = 1020 nM
|
|
|
|
CP0881294
|
2-(5-methyl-furan-2-yl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H18N4O2S
|
1
|
| 1 |
Ki = 1050 nM
|
|
|
|
CP0514726
|
7-(2,6-difluorobenzyl)-2-(ethylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C21H19F2N5O2
|
1
|
| 1 |
Ki = 1053 nM
|
|
|
|
CP0527088
|
2-(cyclopentylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
Ki = 1056 nM
|
|
|
|
CP0856394
|
3-(4-amino-6-(((2S,6R)-2,6-dimethylmorpholino)methyl)thieno[2,3-d]pyrimidin-2-yl)benzonitrile
Show/Hide
|
C20H21N5OS
|
1
|
| 1 |
Ki = 1070 nM
|
|
|
|
CP0514722
|
2-(cyclopropylmethylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
Ki = 1072 nM
|
|
|
|
CP0913904
|
2-(5-chloro-furan-2-yl)-6-(4-fluoro-piperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H16ClFN4OS
|
1
|
| 1 |
Ki = 1080 nM
|
|
|
|
CP0374989
|
2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3,4-dichlorobenzyl)acetamide
Show/Hide
|
C27H21Cl2N3O3
|
1
|
| 1 |
Ki = 1085 nM
|
|
|
|
CP0498034
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(methylamino)-7H-purin-8(9H)-one
Show/Hide
|
C20H17F2N5O2
|
1
|
| 1 |
Ki = 1110 nM
|
|
|
|
CP0380533
|
2-(2-oxo-3-(thiazol-2-yl)-4-(3,3,3-trifluoropropyl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C26H24F3N3O3S
|
1
|
| 1 |
Ki = 1129 nM
|
|
|
|
CP0503027
|
2-(4-(4-fluorophenethyl)-2-oxo-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C31H28FN3O3S
|
1
|
| 1 |
Ki = 1153 nM
|
|
|
|
CP0467097
|
5-(4-amino-6-benzylthieno[2,3-d]pyrimidin-2-yl)pyridine-3-carbonitrile
Show/Hide
|
C19H13N5S
|
1
|
| 1 |
Ki = 1159 nM
|
|
|
|
CP0849566
|
6-(azepan-1-ylmethyl)-2-(furan-2-yl)thieno[2,3-d]-pyrimidin-4-amine
Show/Hide
|
C17H20N4OS
|
1
|
| 1 |
Ki = 1170 nM
|
|
|
|
CP0571394
|
3-fluoro-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C18H23FN4O3S
|
1
|
| 1 |
Ki = 1173 nM
|
|
|
|
CP0529814
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-4-ylmethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H20F2N6O2
|
1
|
| 1 |
Ki = 1191 nM
|
|
|
|
CP0576200
|
4-(fluoromethyl)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C19H25FN4O3S
|
1
|
| 1 |
Ki = 1198 nM
|
|
|
|
CP0514727
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-2-ylmethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H20F2N6O2
|
1
|
| 1 |
Ki = 1211 nM
|
|
|
|
CP0481702
|
1-(4-(5-benzoyl-4-(furan-2-yl)thiazol-2-ylamino)piperidin-1-yl)ethanone
Show/Hide
|
C21H21N3O3S
|
1
|
| 1 |
Ki = 1240 nM
|
|
|
|
CP0864802
|
6-(3,3-difluoro-pyrrolidin-1-ylmethyl)-2-furan-2-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H14F2N4OS
|
1
|
| 1 |
Ki = 1240 nM
|
|
|
|
CP0374400
|
2-(cyclopropylamino)-7-(2-methoxyphenyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21N5O3
|
1
|
| 1 |
Ki = 1265 nM
|
|
|
|
CP0507788
|
(4-(furan-2-yl)-2-(isobutylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C18H18N2O2S
|
1
|
| 1 |
Ki = 1280 nM
|
|
|
|
CP0541941
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-3-ylmethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H20F2N6O2
|
1
|
| 1 |
Ki = 1298 nM
|
|
|
|
CP0374987
|
2-(3-(methylsulfonyl)-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-phenylacetamide
Show/Hide
|
C26H24N2O5S
|
1
|
| 1 |
Ki = 1334 nM
|
|
|
|
CP0901908
|
6-(3-fluoro-pyrrolidin-1-ylmethyl)-2-furan-2-ylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H15FN4OS
|
1
|
| 1 |
Ki = 1340 nM
|
|
|
|
CP0386040
|
2-(2-oxo-4-phenethyl-3-(pyridin-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C33H31N3O3
|
1
|
| 1 |
Ki = 1370 nM
|
|
|
|
CP0378958
|
2-(4-methyl-1,3-thiazol-2-yl)-6-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H16N4S2
|
1
|
| 1 |
Ki = 1416 nM
|
|
|
|
CP0409947
|
6-benzyl-2-pyridin-3-ylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H14N4S
|
1
|
| 1 |
Ki = 1418 nM
|
|
|
|
CP0850772
|
6-azepan-1-ylmethyl-2-(5-chloro-furan-2-yl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H19ClN4OS
|
1
|
| 1 |
Ki = 1420 nM
|
|
|
|
CP0474661
|
(4-(furan-2-yl)-2-(furan-2-ylmethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C19H14N2O3S
|
1
|
| 1 |
Ki = 1460 nM
|
|
|
|
CP0474811
|
7-(2,6-difluorobenzyl)-2-(2-methoxyethylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21F2N5O3
|
1
|
| 1 |
Ki = 1473 nM
|
|
|
|
CP0378957
|
6-benzyl-2-(4-methyl-1,3-thiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H14N4S2
|
1
|
| 1 |
Ki = 1491 nM
|
|
|
|
CP0573418
|
N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C18H24N4O3S
|
1
|
| 1 |
Ki = 1559 nM
|
|
|
|
CP0500973
|
1,3-Dimethyl-8-[3-(2-pyrrolidin-1-ylethoxy)-phenyl]xanthine
Show/Hide
|
C19H23N5O3
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0281180
|
N-(7-acetamido-4-methoxy-1,3-benzothiazol-2-yl)-4-fluorobenzamide
Show/Hide
|
C17H14FN3O3S
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0439006
|
N-[7-[acetyl-[2-(dimethylamino)-2-oxoethyl]amino]-4-methoxy-1,3-benzothiazol-2-yl]-4-fluorobenzamide
Show/Hide
|
C21H21FN4O4S
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0881295
|
4-[4-amino-6-(3,6-dihydro-2H-pyridin-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C19H17N5S
|
1
|
| 1 |
Ki = 1630 nM
|
|
|
|
CP0864797
|
2-(5-difluoromethyl-furan-2-yl)-6-(4-fluoropiperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H17F3N4OS
|
1
|
| 1 |
Ki = 1670 nM
|
|
|
|
CP0124542
|
2-(furan-2-yl)-6-(morpholin-4-ylmethyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C15H16N4O2S
|
1
|
| 1 |
Ki = 1680 nM
|
|
|
|
CP0572012
|
4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C18H24N4O4S
|
1
|
| 1 |
Ki = 1719 nM
|
|
|
|
CP0386086
|
N-tert-butyl-2-[[2-oxo-4-(2-phenylethyl)-3-(1,3-thiazol-2-yl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C26H27N3O3S
|
1
|
| 1 |
Ki = 1720 nM
|
|
|
|
CP0378956
|
3-[4-amino-6-(1-phenylethyl)thieno[2,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C21H16N4S
|
1
|
| 1 |
Ki = 1772 nM
|
|
|
|
CP0514723
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(2-(pyridin-2-yl)ethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C26H22F2N6O2
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0898593
|
6-(3,3-difluoro-piperidin-1-ylmethyl)-2-(3-methoxy-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C19H20F2N4OS
|
1
|
| 1 |
Ki = 1810 nM
|
|
|
|
CP0502581
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-3-ylamino)-7H-purin-8(9H)-one
Show/Hide
|
C24H18F2N6O2
|
1
|
| 1 |
Ki = 1833 nM
|
|
|
|
CP0522423
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-m-tolyl-7H-purin-8(9H)-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
Ki = 1847 nM
|
|
|
|
CP0849519
|
6-cyclopropylaminomethyl-2-furan-2-yl-thieno-[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C14H14N4OS
|
1
|
| 1 |
Ki = 1890 nM
|
|
|
|
CP0474813
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(2-(thiophen-2-yl)ethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H21F2N5O2S
|
1
|
| 1 |
Ki = 1967 nM
|
|
|
|
CP0856393
|
3-[4-amino-6-(2,5-dihydro-pyrrol-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C18H15N5S
|
1
|
| 1 |
Ki = 2070 nM
|
|
|
|
CP0440683
|
1,3-Dimethyl-8-[3-(2-morpholin-4-ylethoxy)-phenyl]xanthine
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
Ki = 2100 nM
|
|
|
|
CP0474766
|
1,3-Dimethyl-8-[3-(2-piperidin-4-ylethoxy)phenyl]xanthine
Show/Hide
|
C20H25N5O3
|
1
|
| 1 |
Ki = 2100 nM
|
|
|
|
CP0946688
|
2-(5-difluoromethyl-furan-2-yl)-6-(3,3-difluoropiperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H16F4N4OS
|
1
|
| 1 |
Ki = 2100 nM
|
|
|
|
CP0946682
|
6-diethylaminomethyl-2-furan-2-yl-thieno[2,3-d]-pyrimidin-4-ylamine
Show/Hide
|
C15H18N4OS
|
1
|
| 1 |
Ki = 2130 nM
|
|
|
|
CP0946689
|
6-(4,4-difluoro-piperidin-1-ylmethyl)-2-furan-2-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H16F2N4OS
|
1
|
| 1 |
Ki = 2230 nM
|
|
|
|
CP0867274
|
2-(3,5-difluoro-phenyl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H16F2N4OS
|
1
|
| 1 |
Ki = 2300 nM
|
|
|
|
CP0381543
|
6-benzyl-2-(1-methylimidazol-4-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H15N5S
|
1
|
| 1 |
Ki = 2332 nM
|
|
|
|
CP0849511
|
4-[4-amino-6-(2,5-dihydro-pyrrol-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C18H15N5S
|
1
|
| 1 |
Ki = 2350 nM
|
|
|
|
CP0495406
|
N-[2-[[5-benzoyl-4-(furan-2-yl)-1,3-thiazol-2-yl]amino]ethyl]acetamide
Show/Hide
|
C18H17N3O3S
|
1
|
| 1 |
Ki = 2420 nM
|
|
|
|
CP0864793
|
6-cyclohexylaminomethyl-2-furan-2-yl-thieno-[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H20N4OS
|
1
|
| 1 |
Ki = 2480 nM
|
|
|
|
CP0446639
|
2-(N-(2-(4-fluorobenzamido)-4-methoxybenzo[d]thiazol-7-yl)acetamido)acetic acid
Show/Hide
|
C19H16FN3O5S
|
1
|
| 1 |
Ki = 2600 nM
|
|
|
|
CP0880226
|
2-(5-difluoromethyl-furan-2-yl)-6-morpholin-4-ylmethyl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C16H16F2N4O2S
|
1
|
| 1 |
Ki = 2700 nM
|
|
|
|
CP0867275
|
1-(4-amino-2-furan-2-yl-thieno[2,3-d]pyrimidin-6-ylmethyl)-piperidin-4-one
Show/Hide
|
C16H16N4O2S
|
1
|
| 1 |
Ki = 2720 nM
|
|
|
|
CP0898636
|
6-morpholin-4-ylmethyl-2-thiazol-2-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C14H15N5OS2
|
1
|
| 1 |
Ki = 2730 nM
|
|
|
|
CP0381546
|
2-(5-methylfuran-2-yl)-6-(2-phenylethyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H17N3OS
|
1
|
| 1 |
Ki = 2784 nM
|
|
|
|
CP0502582
|
7-(2-chlorobenzyl)-2-(cyclopropylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H20ClN5O2
|
1
|
| 1 |
Ki = 2850 nM
|
|
|
|
CP0571395
|
4-fluoro-4-(hydroxymethyl)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C19H25FN4O4S
|
1
|
| 1 |
Ki = 2887 nM
|
|
|
|
CP0849561
|
2-(3,4-difluoro-phenyl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H16F2N4OS
|
1
|
| 1 |
Ki = 2890 nM
|
|
|
|
CP0849555
|
3-[4-amino-6-(4-fluoro-piperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C19H18FN5S
|
1
|
| 1 |
Ki = 2950 nM
|
|
|
|
CP0499311
|
6-benzyl-2-(oxolan-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C17H17N3OS
|
1
|
| 1 |
Ki = 2954 nM
|
|
|
|
CP0856401
|
6-((5,6-dihydropyridin-1(2H)-yl)methyl)-2-(oxazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C15H15N5OS
|
1
|
| 1 |
Ki = 2960 nM
|
|
|
|
CP0910459
|
6-((2,5-dihydro-1H-pyrrol-1-yl)methyl)-2-(3-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H15F3N4S
|
1
|
| 1 |
Ki = 2960 nM
|
|
|
|
CP0856395
|
6-(3,6-dihydro-2H-pyridin-1-ylmethyl)-2-oxazol-4-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H15N5OS
|
1
|
| 1 |
Ki = 2964 nM
|
|
|
|
CP0541942
|
2-(benzylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C26H21F2N5O2
|
1
|
| 1 |
Ki = 2972 nM
|
|
|
|
CP0505747
|
(4-(furan-2-yl)-2-(thiophen-2-ylmethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C19H14N2O2S2
|
1
|
| 1 |
Ki = 2990 nM
|
|
|
|
CP0853664
|
2-(3-methoxy-phenyl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C18H20N4O2S
|
1
|
| 1 |
Ki = 2990 nM
|
|
|
|
CP0497575
|
6-benzyl-2-[5-(difluoromethyl)furan-2-yl]thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H13F2N3OS
|
1
|
| 1 |
Ki = 2998 nM
|
|
|
|
CP0898637
|
6-((4-fluoropiperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H18F4N4S
|
1
|
| 1 |
Ki = 3030 nM
|
|
|
|
CP0381545
|
5-(4-amino-6-benzylthieno[2,3-d]pyrimidin-2-yl)furan-2-carbonitrile
Show/Hide
|
C18H12N4OS
|
1
|
| 1 |
Ki = 3163 nM
|
|
|
|
CP0910460
|
6-(4-fluoro-piperidin-1-ylmethyl)-2-(3-methoxyphenyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C19H21FN4OS
|
1
|
| 1 |
Ki = 3220 nM
|
|
|
|
CP0511562
|
3-(2-(cyclopropylamino)-7-(2-methoxybenzyl)-8-oxo-7H-purin-9(8H)-yl)benzonitrile
Show/Hide
|
C23H20N6O2
|
1
|
| 1 |
Ki = 3237 nM
|
|
|
|
CP0946690
|
6-morpholin-4-ylmethyl-2-oxazol-2-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C14H15N5O2S
|
1
|
| 1 |
Ki = 3250 nM
|
|
|
|
CP0380531
|
N-[[2-oxo-4-(2-phenylethyl)-3-(1,3-thiazol-2-yl)-1H-quinolin-6-yl]methyl]-3-phenylpropanamide
Show/Hide
|
C30H27N3O2S
|
1
|
| 1 |
Ki = 3253 nM
|
|
|
|
CP0849547
|
6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-(5-methyl-furan-2-yl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C21H20N4OS
|
1
|
| 1 |
Ki = 3320 nM
|
|
|
|
CP0234129
|
A2A
Show/Hide
|
C19H26N4O4S
|
1
|
| 1 |
Ki = 3380 nM
|
|
|
|
CP0417762
|
(4-(furan-2-yl)-2-((furan-2-ylmethyl)(methyl)amino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C20H16N2O3S
|
1
|
| 1 |
Ki = 3420 nM
|
|
|
|
CP0387915
|
(2-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C23H18N2O4S
|
1
|
| 1 |
Ki = 3500 nM
|
|
|
|
CP0856402
|
6-dimethylaminomethyl-2-furan-2-yl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C13H14N4OS
|
1
|
| 1 |
Ki = 3550 nM
|
|
|
|
CP0910461
|
6-((4-fluoropiperidin-1-yl)methyl)-2-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H18F4N4S
|
1
|
| 1 |
Ki = 3560 nM
|
|
|
|
CP0387916
|
(4-(furan-2-yl)-2-(methylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C15H12N2O2S
|
1
|
| 1 |
Ki = 3580 nM
|
|
|
|
CP0398044
|
2-(3-(2,4-difluorophenyl)-1-methyl-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3-methoxypropyl)acetamide
Show/Hide
|
C30H30F2N2O4
|
1
|
| 1 |
Ki = 3623 nM
|
|
|
|
CP0474663
|
(2-(1-(2-fluorobenzyl)piperidin-4-ylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C26H24FN3O2S
|
1
|
| 1 |
Ki = 3710 nM
|
|
|
|
CP0498598
|
6-benzyl-2-pyridin-2-ylthieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H14N4S
|
1
|
| 1 |
Ki = 3713 nM
|
|
|
|
CP0849568
|
6-((2,5-dihydro-1H-pyrrol-1-yl)methyl)-2-(oxazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C14H13N5OS
|
1
|
| 1 |
Ki = 3890 nM
|
|
|
|
CP0849559
|
6-(2,5-dihydro-pyrrol-1-ylmethyl)-2-oxazol-4-ylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C14H13N5OS
|
1
|
| 1 |
Ki = 3895 nM
|
|
|
|
CP0386037
|
N-[(3,4-dichlorophenyl)methyl]-2-[(4-methyl-3-methylsulfonyl-2-oxo-1H-quinolin-6-yl)oxy]acetamide
Show/Hide
|
C20H18Cl2N2O5S
|
1
|
| 1 |
Ki = 3914 nM
|
|
|
|
CP0502120
|
(4-(furan-2-yl)-2-(2-methoxypropylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C18H18N2O3S
|
1
|
| 1 |
Ki = 3970 nM
|
|
|
|
CP0856396
|
1-(4-amino-2-furan-2-yl-thieno[2,3-d]pyrimidin-6-ylmethyl)-piperidin-4-ol
Show/Hide
|
C16H18N4O2S
|
1
|
| 1 |
Ki = 4000 nM
|
|
|
|
CP0474814
|
2-(cyclopropylamino)-9-(3,5-dimethoxyphenyl)-7-(2-methoxybenzyl)-7H-purin-8(9H)-one
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
Ki = 4640 nM
|
|
|
|
CP0513784
|
4-(2-fluoroethyl)-4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C20H27FN4O4S
|
1
|
| 1 |
Ki = 4802 nM
|
|
|
|
CP0849565
|
2-[4-amino-6-(4-fluoro-piperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C19H18FN5S
|
1
|
| 1 |
Ki = 5050 nM
|
|
|
|
CP0514724
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(3-(trifluoromethoxy)phenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H20F3N5O3
|
1
|
| 1 |
Ki = 5138 nM
|
|
|
|
CP0386034
|
2-(4-isopentyl-2-oxo-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C28H31N3O3S
|
1
|
| 1 |
Ki = 5999 nM
|
|
|
|
CP0501818
|
2-(3-(2,4-difluorophenyl)-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3-methoxypropyl)acetamide
Show/Hide
|
C29H28F2N2O4
|
1
|
| 1 |
Ki = 6050 nM
|
|
|
|
CP0515271
|
(4-(furan-2-yl)-2-(3-phenylpropylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C23H20N2O2S
|
1
|
| 1 |
Ki = 6300 nM
|
|
|
|
CP0877429
|
2-furan-2-yl-6-pyrrolidin-1-ylmethyl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H16N4OS
|
1
|
| 1 |
Ki = 6430 nM
|
|
|
|
CP0515571
|
N-[4-(2-fluoroethoxy)-7-morpholin-4-yl-1,3-benzothiazol-2-yl]-4-hydroxy-4-methylpiperidine-1-carboxamide
Show/Hide
|
C20H27FN4O4S
|
1
|
| 1 |
Ki = 6663 nM
|
|
|
|
CP0462675
|
(4-(furan-2-yl)-2-(2-methoxyethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C17H16N2O3S
|
1
|
| 1 |
Ki = 6780 nM
|
|
|
|
CP0493532
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3-ethoxy-4-hydroxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H23N7O6
|
1
|
| 1 |
Ki = 6944 nM
|
|
|
|
CP0501667
|
N-benzyl-2-[3-(2,4-difluorophenyl)-1-methyl-2-oxo-4-(2-phenylethyl)quinolin-6-yl]oxyacetamide
Show/Hide
|
C33H28F2N2O3
|
1
|
| 1 |
Ki = 7027 nM
|
|
|
|
CP0477487
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-pyridin-2-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H22N8O4
|
1
|
| 1 |
Ki = 7536 nM
|
|
|
|
CP0512130
|
4-methoxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C19H26N4O4S
|
1
|
| 1 |
Ki = 7563 nM
|
|
|
|
CP0455802
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-phenylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C23H23N7O4
|
1
|
| 1 |
Ki = 7856 nM
|
|
|
|
CP0486347
|
4-(2-fluoroethoxymethyl)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C21H29FN4O4S
|
1
|
| 1 |
Ki = 7975 nM
|
|
|
|
CP0946686
|
4-[4-amino-6-(4-fluoro-piperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-2-yl]-benzonitrile
Show/Hide
|
C19H18FN5S
|
1
|
| 1 |
Ki = 8430 nM
|
|
|
|
CP0511564
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(2-morpholinoethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H26F2N6O3
|
1
|
| 1 |
Ki = 8598 nM
|
|
|
|
CP0386038
|
N-[(3,4-dichlorophenyl)methyl]-2-[(3-methylsulfonyl-2-oxo-4-phenyl-1H-quinolin-6-yl)oxy]acetamide
Show/Hide
|
C25H20Cl2N2O5S
|
1
|
| 1 |
Ki = 8603 nM
|
|
|
|
CP0537945
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3-methoxy-4-phenylmethoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C25H27N7O6
|
1
|
| 1 |
Ki = 9142 nM
|
|
|
|
CP0495407
|
(2-(benzyl(methyl)amino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C22H18N2O2S
|
1
|
| 1 |
Ki = 9460 nM
|
|
|
|
CP0518339
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[2-methyl-3-(4-propan-2-ylphenyl)propylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C23H31N7O4
|
1
|
| 1 |
Ki = 9502 nM
|
|
|
|
CP0258379
|
9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]triazolo[5,1-a][2,7]naphthyridine-6-carboxylic acid methyl ester
Show/Hide
|
C18H16N4O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0466523
|
8-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0511563
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(3-methoxybenzyl)-7H-purin-8(9H)-one
Show/Hide
|
C24H25N5O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0529815
|
7-(2,6-difluorobenzyl)-2-(2-(dimethylamino)ethylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H24F2N6O2
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0377678
|
(4-(furan-2-yl)-2-(methyl(2-(thiophen-2-yl)ethyl)amino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C21H18N2O2S2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0400196
|
(2-(benzyl(furan-2-ylmethyl)amino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C26H20N2O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0462676
|
(2-(dimethylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C16H14N2O2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0462677
|
(2-(benzyl(2-(thiophen-2-yl)ethyl)amino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C27H22N2O2S2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0380530
|
N-[(3,4-dichlorophenyl)methyl]-2-[1-methyl-3-methylsulfonyl-2-oxo-4-(2-phenylethyl)quinolin-6-yl]oxyacetamide
Show/Hide
|
C28H26Cl2N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0501647
|
6-methoxy-3-(methylsulfonyl)-4-phenethylquinolin-2(1H)-one
Show/Hide
|
C19H19NO4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0501668
|
N-(cyclopropylmethyl)-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C24H26N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0849557
|
6-pyrrolidin-1-ylmethyl-2-thiophen-2-yl-thieno-[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H16N4S2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0849567
|
6-((4-fluoropiperidin-1-yl)methyl)-2-(3-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H18FN5O2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0849569
|
6-((4-fluoropiperidin-1-yl)methyl)-2-(3-(methylsulfonyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H21FN4O2S2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0849570
|
3-(4-amino-6-((4-fluoropiperidin-1-yl)methyl)thieno[2,3-d]pyrimidin-2-yl)-N,N-dimethylbenzamide
Show/Hide
|
C21H24FN5OS
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0910462
|
6-((4-fluoropiperidin-1-yl)methyl)-2-(2-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H18F4N4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0444810
|
N-[4-[(E)-[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hydrazinylidene]methyl]phenyl]acetamide
Show/Hide
|
C19H22N8O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0444814
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-propoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H25N7O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0444815
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[3,4-bis(phenylmethoxy)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C31H31N7O6
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0455801
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-imidazol-1-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H21N9O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0455804
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H24N8O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0455806
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-(N-phenylanilino)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C29H28N8O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0455810
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[2,4-bis(trifluoromethyl)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H17F6N7O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0455811
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(3-methylsulfanylpropylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C14H21N7O4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0477486
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-chloro-3-(trifluoromethyl)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C18H17ClF3N7O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0518342
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3,4,5-trimethoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H25N7O7
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386035
|
N-(3-methoxypropyl)-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C24H28N2O6S
|
1
|
| 1 |
Ki = 10443 nM
|
|
|
|
CP0474768
|
1,3-Dimethyl-8-[3-methoxy-4-(2-pyrrolidin-4-ylethoxy)-phenyl]xanthine
Show/Hide
|
C20H25N5O4
|
1
|
| 1 |
Ki = 11200 nM
|
|
|
|
CP0515731
|
8-[3-(2-Dimethylaminoethoxy)-4-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C18H23N5O4
|
1
|
| 1 |
Ki = 13500 nM
|
|
|
|
CP0500972
|
8-[3-(2-Diethylaminoethoxy)phenyl]-1,3-dimethylxanthine
Show/Hide
|
C19H25N5O3
|
1
|
| 1 |
Ki = 14000 nM
|
|
|
|
CP0054092
|
1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-1H-pyrazole-4-carboxylic acid methylamide
Show/Hide
|
C15H18N8O5
|
1
|
| 1 |
Ki > 16460 nM
|
|
|
|
CP0515569
|
4-(2-fluoro-1-hydroxyethyl)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C20H27FN4O4S
|
1
|
| 1 |
Ki = 16680 nM
|
|
|
|
CP0958449
|
2-(5-difluoromethyl-furan-2-yl)-6-(4,4-difluoropiperidin-1-ylmethyl)-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H16F4N4OS
|
1
|
| 1 |
Ki = 17820 nM
|
|
|
|
CP0486348
|
4-(1-fluoro-2-hydroxypropan-2-yl)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C21H29FN4O4S
|
1
|
| 1 |
Ki > 20000 nM
|
|
|
|
CP0555507
|
4-(2-fluoroethoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
Show/Hide
|
C20H27FN4O4S
|
1
|
| 1 |
Ki > 20000 nM
|
|
|
|
CP0522546
|
8-[3-(2-Diethylaminoethoxy)-4-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C20H27N5O4
|
1
|
| 1 |
Ki = 43000 nM
|
|
|
|
CP0435442
|
1,3-Dimethyl-8-[4-methoxy-3-(2-piperidin-1-ylethoxy)-phenyl]xanthine
Show/Hide
|
C21H27N5O4
|
1
|
| 1 |
Ki > 100000 nM
|
|
|
|
CP0435443
|
8-[4-(2-Diethylaminoethoxy)-3-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C20H27N5O4
|
1
|
| 1 |
Ki > 100000 nM
|
|
|
|
CP0474765
|
1,3-Dimethyl-8-[3-methoxy-4-(2-morpholin-4-ylethoxy)-phenylxanthine
Show/Hide
|
C20H25N5O5
|
1
|
| 1 |
Ki > 100000 nM
|
|
|
|
CP0501820
|
8-[4-(2-Dimethylaminoethoxy)-3-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C18H23N5O4
|
1
|
| 1 |
Ki > 100000 nM
|
|
|
|
CP0515729
|
1,3-Dimethyl-8-[3-methoxy-4-(2-piperidin-1-ylethoxy)-phenyl]xanthine
Show/Hide
|
C21H27N5O4
|
1
|
| 1 |
Ki > 100000 nM
|
|
|
|
CP0542913
|
1,3-Dimethyl-8-[4-methoxy-3-(2-morpholin-4-ylethoxy)-phenylxanthine
Show/Hide
|
C20H25N5O5
|
1
|
| 1 |
Ki > 100000 nM
|
|
|
|
CP0409954
|
2-(4-methyl-1,3-thiazol-2-yl)-6-(1-phenylethenyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H14N4S2
|
1
|
| 1 |
Ki > 594 nM
|
|
|
|
CP0864798
|
2-(5-isopropyl-furan-2-yl)-6-morpholin-4-ylmethyl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C18H22N4O2S
|
1
|
| 1 |
Ki > 600 nM
|
|
|
|
CP0396327
|
2-(4-methyl-1,3-thiazol-2-yl)-6-(1-phenylcyclopropyl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C19H16N4S2
|
1
|
| 1 |
Ki > 610 nM
|
|
|
|
CP0515279
|
3-[4-amino-6-(1-phenylcyclopropyl)thieno[2,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C22H16N4S
|
1
|
| 1 |
Ki > 610 nM
|
|
|
|
CP0856392
|
2-(5-ethyl-furan-2-yl)-6-morpholin-4-ylmethylthieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C17H20N4O2S
|
1
|
| 1 |
Ki > 610 nM
|
|
|
|
CP0856403
|
2-(4-methyl-thiazol-2-yl)-6-morpholin-4-ylmethyl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C15H17N5OS2
|
1
|
| 1 |
Ki > 930 nM
|
|
|
|
CP0439086
|
3-[4-amino-6-(1-phenylethenyl)thieno[2,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C21H14N4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0467098
|
6-benzyl-2-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C20H14F3N3S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0523782
|
6-benzyl-2-(6-chloropyridin-2-yl)thieno[2,3-d]pyrimidin-4-amine
Show/Hide
|
C18H13ClN4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0536867
|
6-(4-amino-6-benzylthieno[2,3-d]pyrimidin-2-yl)pyridine-2-carbonitrile
Show/Hide
|
C19H13N5S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0849563
|
2-(5-cyclopropyl-furan-2-yl)-6-morpholin-4-ylmethyl-thieno[2,3-d]pyrimidin-4-ylamine
Show/Hide
|
C18H20N4O2S
|
1
|
| 1 |
Ki > 1100 nM
|
|
|
|
CP0856400
|
6-(morpholinomethyl)-2-phenylthieno[2,3-d]-pyrimidin-4-amine
Show/Hide
|
C17H18N4OS
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0045912
|
(4-(furan-2-yl)-2-(2-(thiophen-2-yl)ethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C20H16N2O2S2
|
1
|
| 1 |
Ki > 6700 nM
|
|
|
|
CP0474662
|
(2-(3,4-difluorobenzylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C21H14F2N2O2S
|
1
|
| 1 |
Ki > 7500 nM
|
|
|
