Brief Information of the Cell Line and Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
Synonyms
BTI-TN-5B1-4
BTI-TN5B1-4
BTI-Tn5B14
BTI-Tn 5B1-4
Tn-5B1-4
Tn 5B1-4
Tn5 B1-4
Tn5B1-4
TN5B14
TnH5
High Five
High 5
High-5
High5
Hi-five
Hi-5
Hi5
Tn-5
Category Spontaneously immortalized cell line
Organism
Trichoplusia ni (Cabbage looper)
Cellosaurus ID
CVCL_C190
Protein ID: PT00980 , Aurora kinase A
Gene Name AURKA
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID O14965
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000023  Protein ID: PT00980
 
Compound ID Compound Name Compound Formula
CP0430625
4-methyl-N-(3-(2-(6-methyl-5-(2-(thiophen-2-yl)acetamido)-1H-indazol-3-yl)vinyl)phenyl)piperazine-1-carboxamide
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C28H30N6O2S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0470449
N-[6-methyl-3-[(E)-2-phenylethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide
   Show/Hide
C22H19N3OS
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0490727
N-[6-methyl-3-[(E)-2-phenylethenyl]-1H-indazol-5-yl]-2-phenylacetamide
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C24H21N3O
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0486037
2-phenyl-N-(3-styryl-1H-indazol-5-yl)acetamide
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C23H19N3O
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0376394
1-phenyl-N-(3-styryl-1H-indazol-5-yl)methanesulfonamide
   Show/Hide
C22H19N3O2S
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0477498
N-[3-[(E)-2-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]ethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide
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C27H29N5OS
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0452085
2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-indazol-5-yl)acetamide
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C26H25N3O3
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0376392
N-[6-methyl-3-[(E)-2-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]ethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide
   Show/Hide
C28H31N5OS
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0477500
N-[3-[(E)-2-phenylethenyl]-6-pyrrolidin-1-yl-1H-indazol-5-yl]-2-thiophen-2-ylacetamide
   Show/Hide
C25H24N4OS
 1
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0430626
4-methyl-N-(3-(2-(5-(methylsulfonamido)-6-(pyrrolidin-1-yl)-1H-indazol-3-yl)vinyl)phenyl)piperazine-1-carboxamide
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C26H33N7O3S
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0470476
5-(pyridin-4-yl)-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole
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C24H22N4
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0477501
6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine
   Show/Hide
C19H20N4
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0376393
5-nitro-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole
   Show/Hide
C19H18N4O2
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0502849
N-[6-methyl-3-(2-phenylethynyl)-2H-indazol-5-yl]-2-thiophen-2-ylacetamide
   Show/Hide
C22H17N3OS
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0417624
4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazole-5-carbonitrile
   Show/Hide
C23H25N5
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0430624
3-methyl-5-(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)aniline
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C29H33N5
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0494484
3-[(E)-2-phenylethenyl]-N-(pyridin-2-ylmethyl)-6-pyrrolidin-1-yl-1H-indazol-5-amine
   Show/Hide
C25H25N5
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0470451
2-phenyl-N-(3-(2-phenylcyclopropyl)-1H-indazol-5-yl)acetamide
   Show/Hide
C24H21N3O
 1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
CP0417626
2-phenyl-N-[3-(2-phenylethyl)-2H-indazol-5-yl]acetamide
   Show/Hide
C23H21N3O
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0470045
N-[4-methyl-3-[(E)-2-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]ethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide
   Show/Hide
C28H31N5OS
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0504238
6-(4-methylpiperazin-1-yl)-N-(pyridin-2-ylmethyl)-3-styryl-1H-indazol-5-amine
   Show/Hide
C26H28N6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS