Brief Information of the Cell Line and Protein
Cell Line ID: CL000017 , HeLa
Synonyms
HELA
Hela
He La
He-La
HeLa-CCL2
Henrietta Lacks cells
Helacyton gartleri
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0030
Protein ID: PT00865 , Serine/threonine-protein kinase Chk1
Gene Name CHEK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID O14757
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000017  Protein ID: PT00865
 
Compound ID Compound Name Compound Formula
CP0333594
methyl 2-[9-(4-amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]acetate
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C23H21N3O4
 1
1
EC50 = 890 nM
   TI
   LI
   LO
   TS
CP0286129
3-(4-amino-3-methoxy-phenyl)-7-morpholin-4-yl-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one
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C24H24N4O3
 2
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
2
EC50 = 46100 nM
   TI
   LI
   LO
   TS
CP0510897
4'-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-biphenyl-4-ol
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C29H29N3O2
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0065182
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N,N-dimethylacetamide
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C24H24N4O3
 1
1
EC50 = 2630 nM
   TI
   LI
   LO
   TS
CP0405447
4'-(6-{[(5-methyl-pyrazin-2-ylmethyl)-amino]-methyl}-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol
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C29H25N5O
 1
1
EC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0400040
4'-[6-(4-Hydroxy-cyclohexylmethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]-biphenyl-4-ol
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C28H27N3O2
 1
1
EC50 = 4700 nM
   TI
   LI
   LO
   TS
CP0065184
8-(1,1-dioxo-1l6-isothiazolidin-2-yl)-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one
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C23H22N4O4S
 2
1
EC50 = 9000 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0020879
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide
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C34H35N5O4
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 59300 nM
   TI
   LI
   LO
   TS
CP0021747
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-[4-(4-morpholinyl)phenyl]acetamide
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C32H31N5O4
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 59300 nM
   TI
   LI
   LO
   TS
CP0065181
3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-(4-morpholin-4-ylphenyl)propanamide
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C33H33N5O4
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 59300 nM
   TI
   LI
   LO
   TS
CP0065183
3-(3-methoxy-4-nitrophenyl)-8-(2-oxopyrrolidin-1-yl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
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C24H22N4O3
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 = 49500 nM
   TI
   LI
   LO
   TS
CP0185338
7-amino-3-(4-amino-3-methoxy-phenyl)-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one
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C20H18N4O2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 = 49900 nM
   TI
   LI
   LO
   TS
CP0195563
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-7-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide
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C34H35N5O4
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 59300 nM
   TI
   LI
   LO
   TS
CP0270494
8-methoxy-3-(3-methoxy-4-nitrophenyl)-5H-dibenzo[b,e][1,4]-diazepin-11(10H)-one
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C21H19N3O3
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 59300 nM
   TI
   LI
   LO
   TS
CP0333592
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-7-yl]-N,N-dimethylacetamide
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C24H24N4O3
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 = 32500 nM
   TI
   LI
   LO
   TS
CP0333593
3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N,N-dimethylpropanamide
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C25H26N4O3
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 = 51900 nM
   TI
   LI
   LO
   TS
CP0373581
[3-[4-(4-hydroxyphenyl)phenyl]-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]-(4-hydroxypiperidin-1-yl)methanone
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C28H25N3O3
 1
1
EC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0039009
3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE
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C29H27N3O3
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0212707
3-(4'-hydroxy-biphenyl-4-yl)-1,4-dihydro-indeno[1,2-c]pyrazole-6-carboxylic acid (pyridin-4-ylmethyl)-amide
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C29H22N4O2
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0295930
4-(6-(morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
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C22H21N3O3
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0373550
4-(6-(((1r,4r)-4-hydroxycyclohexyl)carbamoyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
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C24H23N3O4
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0374439
4-(6-((4-hydroxypiperidin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
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C23H23N3O3
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0464485
4-(6-(morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzamide
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C22H22N4O2
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0522247
4-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-benzoic acid
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C24H25N3O3
 1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CP0213191
8-hydroxy-3-(3-methoxy-4-nitrophenyl)-5H-dibenzo[b,e][1,4]-diazepin-11(10H)-one
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C20H17N3O3
 1
1
EC50 > 59300 nM
   TI
   LI
   LO
   TS