Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE
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 PubChem ID
SID: 15033695
Canonical SMILES
O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)c1
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Compound Formula C29H27N3O3
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase Chk1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CAMK protein kinase group
>
CAMK protein kinase CAMK1 family
>
CAMK protein kinase CHK1 subfamily
Uniprot ID
O14757
Gene Name
CHEK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 > 59000 nM
   TI
   LI
   LO
   TS
CL000095 NCI-H1299
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CL000104 SW620
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 25200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.2 nM
2 Ki = 6.31 nM