Brief Information of the Cell Line and Protein
Cell Line ID: CL000013 , Sf9
Synonyms
SF9
sf9
SF-9
Sf-9
sf-9
Sf 9
Spodoptera frugiperda clone 9
Sf clone 9
IPLB-Sf-9AE
IPLB-SF-9AE
IPLB-SF-9
IPLB-Sf-9
IPLB-Sf9
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0549
Protein ID: PT01223 , Aurora kinase B
Gene Name AURKB
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q96GD4
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000013  Protein ID: PT01223
 
Compound ID Compound Name Compound Formula
CP0391162
4-[[1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
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C15H11F2N5O3S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0548485
1-(3-chlorophenyl)-3-[5-[2-[[7-[3-(dimethylamino)propoxy]quinazolin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
   Show/Hide
C25H28ClN7O2S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0494134
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(4-methoxyphenyl)urea
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C24H23N5O3
 1
1
IC50 = 22.2 nM
   TI
   LI
   LO
   TS
CP0003401
4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
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C23H30N6O2
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0481968
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-[(dimethylamino)methyl]phenyl]urea
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C30H29ClN6O2
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0389836
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(2-methylphenyl)urea
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C28H24ClN5O2
 1
1
IC50 = 60.2 nM
   TI
   LI
   LO
   TS
CP0455629
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(2-ethylphenyl)urea
   Show/Hide
C29H26ClN5O2
 1
1
IC50 = 66.2 nM
   TI
   LI
   LO
   TS
CP0432163
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-phenylurea
   Show/Hide
C27H22ClN5O2
 1
1
IC50 = 66.3 nM
   TI
   LI
   LO
   TS
CP0489908
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(4-methylphenyl)urea
   Show/Hide
C28H24ClN5O2
 1
1
IC50 = 73.3 nM
   TI
   LI
   LO
   TS
CP0455627
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(3-methylphenyl)urea
   Show/Hide
C28H24ClN5O2
 1
1
IC50 = 74.9 nM
   TI
   LI
   LO
   TS
CP0457859
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-[(4-hydroxypiperidin-1-yl)methyl]phenyl]urea
   Show/Hide
C33H33ClN6O3
 1
1
IC50 = 78.9 nM
   TI
   LI
   LO
   TS
CP0482157
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-[(4-hydroxypiperidin-1-yl)methyl]phenyl]urea
   Show/Hide
C33H33ClN6O3
 1
1
IC50 = 83.6 nM
   TI
   LI
   LO
   TS
CP0875578
1-(4-(2-(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-ylamino)ethyl)phenyl)-3-(3-ethylphenyl)urea
   Show/Hide
C29H26ClN5O2
 1
1
IC50 = 86.1 nM
   TI
   LI
   LO
   TS
CP0519358
1-(4-bromophenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H28BrN5O3S
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0432164
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-(piperidin-1-ylmethyl)phenyl]urea
   Show/Hide
C33H33ClN6O2
 1
1
IC50 = 102.3 nM
   TI
   LI
   LO
   TS
CP0463255
1-(4-chlorophenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]thiourea
   Show/Hide
C27H28ClN5O2S2
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0448719
1-(4-chlorophenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H28ClN5O3S
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0482156
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-(diethylaminomethyl)phenyl]urea
   Show/Hide
C32H33ClN6O2
 1
1
IC50 = 121.5 nM
   TI
   LI
   LO
   TS
CP0552804
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-(piperidin-1-ylmethyl)phenyl]urea
   Show/Hide
C33H33ClN6O2
 1
1
IC50 = 121.6 nM
   TI
   LI
   LO
   TS
CP0476941
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-[[ethyl(methyl)amino]methyl]phenyl]urea
   Show/Hide
C31H31ClN6O2
 1
1
IC50 = 140.4 nM
   TI
   LI
   LO
   TS
CP0482155
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-[(dimethylamino)methyl]phenyl]urea
   Show/Hide
C30H29ClN6O2
 1
1
IC50 = 199 nM
   TI
   LI
   LO
   TS
CP0519356
1-(4-methoxyphenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C28H31N5O4S
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0448721
1-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]-3-phenylurea
   Show/Hide
C27H29N5O3S
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0519354
1-(3,4-dichlorophenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H27Cl2N5O3S
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0519357
1-(4-chlorophenyl)-3-[4-[[[6-[2-(dimethylamino)ethoxy]-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C25H26ClN5O2S
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0536554
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(2-propan-2-ylphenyl)urea
   Show/Hide
C30H28ClN5O2
 1
1
IC50 = 335.9 nM
   TI
   LI
   LO
   TS
CP0457864
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]urea
   Show/Hide
C33H33ClN6O3
 1
1
IC50 = 352.5 nM
   TI
   LI
   LO
   TS
CP0519355
1-(4-methoxyphenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]thiourea
   Show/Hide
C28H31N5O3S2
 1
1
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0547978
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(4-ethylphenyl)urea
   Show/Hide
C29H26ClN5O2
 1
1
IC50 = 443 nM
   TI
   LI
   LO
   TS
CP0552811
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[4-[(dimethylamino)methyl]phenyl]urea
   Show/Hide
C30H29ClN6O2
 1
1
IC50 = 455.5 nM
   TI
   LI
   LO
   TS
CP0470497
1-(3-chlorophenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H28ClN5O3S
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0542794
1-(5-chloro-2-methoxyphenyl)-3-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]urea
   Show/Hide
C26H25ClFN5O3
 1
1
IC50 = 511.8 nM
   TI
   LI
   LO
   TS
CP0457863
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-(diethylaminomethyl)phenyl]urea
   Show/Hide
C32H33ClN6O2
 1
1
IC50 = 526.1 nM
   TI
   LI
   LO
   TS
CP0542800
1-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]urea
   Show/Hide
C27H25F4N5O3
 1
1
IC50 = 548.4 nM
   TI
   LI
   LO
   TS
CP0133124
5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine
   Show/Hide
C20H15ClF3N5
 1
1
IC50 = 643 nM
   TI
   LI
   LO
   TS
CP0481970
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(3-propan-2-ylphenyl)urea
   Show/Hide
C30H28ClN5O2
 1
1
IC50 = 657.1 nM
   TI
   LI
   LO
   TS
CP0448722
1-(4-fluorophenyl)-3-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H28FN5O3S
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0520207
4-methoxy-N-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]benzamide
   Show/Hide
C28H30N4O4S
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0457862
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-(2-methylpropyl)phenyl]urea
   Show/Hide
C31H30ClN5O2
 1
1
IC50 = 700.3 nM
   TI
   LI
   LO
   TS
CP0005066
NR9
   Show/Hide
C18H13N3OS2
 1
1
IC50 = 815 nM
   TI
   LI
   LO
   TS
CP0457860
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[4-(diethylaminomethyl)phenyl]urea
   Show/Hide
C32H33ClN6O2
 1
1
IC50 = 835.2 nM
   TI
   LI
   LO
   TS
CP0548067
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[4-(piperidin-1-ylmethyl)phenyl]urea
   Show/Hide
C33H33ClN6O2
 1
1
IC50 = 945.9 nM
   TI
   LI
   LO
   TS
CP0460395
1-(3-chlorophenyl)-3-[3-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H28ClN5O3S
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0448718
1-(4-chlorophenyl)-3-[3-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C27H28ClN5O3S
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0448717
3-chloro-N-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]benzamide
   Show/Hide
C27H27ClN4O3S
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0253957
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[[6-(trifluoromethyl)pyridin-3-yl]methyl]urea
   Show/Hide
C24H21F3N6O2
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0448720
1-(4-chlorophenyl)-3-[4-[[[6-(2-piperidin-2-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]urea
   Show/Hide
C28H30ClN5O2S
 1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0006184
6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione
   Show/Hide
C14H6O8
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0448716
4-chloro-N-[4-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]benzamide
   Show/Hide
C27H27ClN4O3S
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0460394
1-[3-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]-3-phenylurea
   Show/Hide
C27H29N5O3S
 1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0475044
4-chloro-N-[3-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]benzamide
   Show/Hide
C27H27ClN4O3S
 1
1
IC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0475049
4-fluoro-N-[3-[[[6-(2-morpholin-4-ylethoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenyl]benzamide
   Show/Hide
C27H27FN4O3S
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0001550
1-hydroxy-3-(1-methylindol-3-yl)-4-(1-propan-2-ylindol-3-yl)pyrrole-2,5-dione
   Show/Hide
C24H21N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0001850
6-[3-[1-hydroxy-4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
C27H24N4O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0002105
6-[3-[1-hydroxy-4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanoic acid
   Show/Hide
C27H25N3O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0003248
1-hydroxy-3,4-bis(1-methylindol-3-yl)pyrrole-2,5-dione
   Show/Hide
C22H17N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0003433
(Arylindolyl)maleimide deriv. 27
   Show/Hide
C21H16N4O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0003434
1-hydroxy-3-(1H-indol-3-yl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
   Show/Hide
C21H15N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0003435
3-(1-ethylindol-3-yl)-1-hydroxy-4-(1-propan-2-ylindol-3-yl)pyrrole-2,5-dione
   Show/Hide
C25H23N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0006368
1-hydroxy-3-(1H-indol-3-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrole-2,5-dione
   Show/Hide
C19H12N4O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0006369
6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-1-hydroxy-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
C32H31N5O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0006646
4-hydroxy-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione
   Show/Hide
C26H23N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0010066
6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
C32H31N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0010481
3-(1-ethylindol-3-yl)-1-hydroxy-4-(1-methylindol-3-yl)pyrrole-2,5-dione
   Show/Hide
C23H19N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0013010
1-hydroxy-3-(1H-indol-3-yl)-4-(1-propan-2-ylindol-3-yl)pyrrole-2,5-dione
   Show/Hide
C23H19N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0013451
6-[3-[1-hydroxy-4-(1H-indol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanoic acid
   Show/Hide
C26H23N3O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0003153
(3E)-3-[(2-chloro-1H-indol-3-yl)methylidene]-1H-indol-2-one
   Show/Hide
C17H11ClN2O
 1
1
IC50 = 15600 nM
   TI
   LI
   LO
   TS
CP0009041
5-propan-2-yl-7,8-dihydro-6H-indeno[1,2-b]indole-9,10-dione
   Show/Hide
C18H17NO2
 1
1
IC50 > 35000 nM
   TI
   LI
   LO
   TS
CP0531678
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-(2-methylpropyl)phenyl]urea
   Show/Hide
C31H30ClN5O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0536556
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-(4-propan-2-ylphenyl)urea
   Show/Hide
C30H28ClN5O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0536557
1-[4-[2-[(5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[4-(2-methylpropyl)phenyl]urea
   Show/Hide
C31H30ClN5O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS