Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT02446 , Metabotropic glutamate receptor 4
Gene Name GRM4
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P31423
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT02446
 
Compound ID Compound Name Compound Formula
CP0420635
N-[1-(5-chloro-3-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C19H17ClFN5O
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0047496
N-[4-[(2-chlorobenzoyl)amino]-3-methoxy-phenyl]picolinamide
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C20H16ClN3O3
 1
1
EC50 = 106 nM
   TI
   LI
   LO
   TS
CP0420630
N-[1-(3-chloro-5-cyanopyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C20H17ClN6O
 1
1
EC50 = 138 nM
   TI
   LI
   LO
   TS
CP0091077
N-[3-chloro-4-[(2-chloro-4-fluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H12Cl2FN3O2
 1
1
EC50 = 169 nM
   TI
   LI
   LO
   TS
CP0420634
N-[1-(3-chloro-5-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C19H17ClFN5O
 1
1
EC50 = 174 nM
   TI
   LI
   LO
   TS
CP0444514
N-[1-(2,5-dichloropyridin-4-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C19H17Cl2N5O
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0469467
N-[1-(5-chloro-2-methoxypyridin-4-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C20H20ClN5O2
 1
1
EC50 = 356 nM
   TI
   LI
   LO
   TS
CP0225124
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]-1,3-thiazole-2-carboxamide
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C18H14ClN3O3S
 1
1
EC50 = 377 nM
   TI
   LI
   LO
   TS
CP0500469
N-(4-benzamido-3-chlorophenyl)pyridine-2-carboxamide
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C19H14ClN3O2
 1
1
EC50 = 518 nM
   TI
   LI
   LO
   TS
CP0047495
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1,3-thiazole-2-carboxamide
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C16H11ClN4O2S
 1
1
EC50 = 533 nM
   TI
   LI
   LO
   TS
CP0112401
N-[3-chloranyl-4-[(2-chlorophenyl)carbonylamino]phenyl]pyridine-2-carboxamide
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C19H13Cl2N3O2
 1
1
EC50 = 570 nM
   TI
   LI
   LO
   TS
CP0381483
N-[3-chloro-4-(cyclohexanecarbonylamino)phenyl]pyridine-2-carboxamide
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C19H20ClN3O2
 1
1
EC50 = 592 nM
   TI
   LI
   LO
   TS
CP0057653
N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]picolinamide
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C19H13ClFN3O2
 1
1
EC50 = 739 nM
   TI
   LI
   LO
   TS
CP0469181
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]-1,3-thiazole-4-carboxamide
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C18H14ClN3O3S
 1
1
EC50 = 753 nM
   TI
   LI
   LO
   TS
CP0653640
N-(4-(2-chlorobenzamido)-3-methoxyphenyl)thiophene-2-carboxamide
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C19H15ClN2O3S
 1
1
EC50 = 860 nM
   TI
   LI
   LO
   TS
CP0409522
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]pyrimidine-4-carboxamide
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C19H15ClN4O3
 1
1
EC50 = 894 nM
   TI
   LI
   LO
   TS
CP0047498
N-[3-chloro-4-[(2-methylbenzoyl)amino]phenyl]pyridine-2-carboxamide
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C20H16ClN3O2
 1
1
EC50 = 915 nM
   TI
   LI
   LO
   TS
CP0152699
5-bromo-N-(4-(2-chlorobenzamido)-3-methoxyphenyl)furan-2-carboxamide
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C19H14BrClN2O4
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0047288
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide
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C19H15ClN2O4
 1
1
EC50 = 1010 nM
   TI
   LI
   LO
   TS
CP0465473
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]pyrazine-2-carboxamide
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C19H15ClN4O3
 1
1
EC50 = 1120 nM
   TI
   LI
   LO
   TS
CP0377238
N-[3-chloro-4-(thiophene-2-carbonylamino)phenyl]pyridine-2-carboxamide
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C17H12ClN3O2S
 1
1
EC50 = 1130 nM
   TI
   LI
   LO
   TS
CP0261580
N-[1-(2-methoxybenzoyl)indol-5-yl]pyridine-2-carboxamide
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C22H17N3O3
 1
1
EC50 = 1340 nM
   TI
   LI
   LO
   TS
CP0381482
2-chloro-N-(4-(cyclohexanecarboxamido)-2-methoxyphenyl)benzamide
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C21H23ClN2O3
 1
1
EC50 = 1520 nM
   TI
   LI
   LO
   TS
CP0377240
N-[1-(2-chloro-4-fluorobenzoyl)indol-5-yl]pyridine-2-carboxamide
   Show/Hide
C21H13ClFN3O2
 1
1
EC50 = 1660 nM
   TI
   LI
   LO
   TS
CP0381487
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1,3-thiazole-5-carboxamide
   Show/Hide
C16H11ClN4O2S
 1
1
EC50 = 1730 nM
   TI
   LI
   LO
   TS
CP0381486
N-[3-chloro-4-[(2,4-difluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H12ClF2N3O2
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0377236
N-[4-[(2-chlorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H14ClN3O2
 1
1
EC50 = 2260 nM
   TI
   LI
   LO
   TS
CP0501864
N-[3-chloro-4-[(3,5-dichlorobenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H12Cl3N3O2
 1
1
EC50 = 2340 nM
   TI
   LI
   LO
   TS
CP0377235
N-[4-[(2-chlorobenzoyl)amino]-3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C20H13ClF3N3O2
 1
1
EC50 = 2360 nM
   TI
   LI
   LO
   TS
CP0120363
(1aS,7E,7aS)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
   Show/Hide
C17H14N2O3
 1
1
EC50 = 2820 nM
   TI
   LI
   LO
   TS
CP0381485
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1-methylindole-2-carboxamide
   Show/Hide
C22H17ClN4O2
 1
1
EC50 = 2970 nM
   TI
   LI
   LO
   TS
CP0377239
N-[3-chloro-4-[(5-phenylfuran-2-carbonyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C23H16ClN3O3
 1
1
EC50 = 3350 nM
   TI
   LI
   LO
   TS
CP0377237
N-[3-chloro-4-[(2-fluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H13ClFN3O2
 1
1
EC50 = 4390 nM
   TI
   LI
   LO
   TS
CP0381484
N-[3-chloro-4-(2-methylpropanoylamino)phenyl]pyridine-2-carboxamide
   Show/Hide
C16H16ClN3O2
 1
1
EC50 = 4820 nM
   TI
   LI
   LO
   TS
CP0377241
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]oxolane-2-carboxamide
   Show/Hide
C19H19ClN2O4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0211752
(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
   Show/Hide
C15H14Cl2FNO5
 1
1
IC50 = 1740 nM
   TI
   LI
   LO
   TS
CP0377729
(1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl)cyclopropanecarboxylic acid
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C20H19NO5
 1
1
IC50 = 2650 nM
   TI
   LI
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   TS