Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01105 , Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q14524
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01105
 
Compound ID Compound Name Compound Formula
CP0375108
4-butoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C22H29N3O2
 1
1
IC50 = 560 nM
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CP0444107
4-ethoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C20H25N3O2
 1
1
IC50 = 1100 nM
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CP0391416
3,4,5-trimethoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C21H27N3O4
 1
1
IC50 = 1510 nM
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CP0453500
2-methyl-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C19H23N3O
 1
1
IC50 = 1750 nM
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CP0430912
N-[N'-[2-(5-methoxy-1H-indol-3-yl)ethyl]carbamimidoyl]-4-methylbenzamide
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C20H22N4O2
 1
1
IC50 = 1760 nM
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CP0452262
N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)benzamide
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C22H24F3N3O3
 1
1
IC50 = 1995.26 nM
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CP0453220
4-methoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C19H23N3O2
 1
1
IC50 = 2100 nM
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CP0437894
N-[N'-(4-phenylbutyl)carbamimidoyl]thiophene-2-carboxamide
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C16H19N3OS
 1
1
IC50 = 2350 nM
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CP0493834
2-(2,4-dimethylphenyl)-5-methyl-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C26H32N6O2
 1
1
IC50 = 2511.89 nM
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CP0375122
2,3-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
 1
1
IC50 = 2710 nM
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CP0453181
4-methyl-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C19H23N3O
 1
1
IC50 = 2850 nM
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CP0377581
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H18F3N3O3
 1
1
IC50 = 3162.28 nM
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CP0452264
N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H18F3N3O3
 1
1
IC50 = 3162.28 nM
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CP0506417
N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)benzamide
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C22H17F3N2O3
 1
1
IC50 = 3162.28 nM
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CP0011846
1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one
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C21H27NO3
 2
1
IC50 = 3300 nM
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2
IC50 > 5000 nM
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CP0414861
4-methyl-N-[N'-(5-phenylpentyl)carbamimidoyl]benzamide
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C20H25N3O
 1
1
IC50 = 3600 nM
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CP0440191
4-chloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H20ClN3O
 1
1
IC50 = 3600 nM
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CP0434432
N-[N'-[2-(4-methoxy-1H-indol-3-yl)ethyl]carbamimidoyl]-4-methylbenzamide
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C20H22N4O2
 1
1
IC50 = 3920 nM
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CP0377578
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)benzamide
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C22H17F3N2O3
 1
1
IC50 = 3981.07 nM
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CP0416294
N-[(3S)-5-pyrimidin-5-yl-3,4-dihydro-2H-chromen-3-yl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
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C22H19F3N4O3
 1
1
IC50 = 3981.07 nM
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CP0436277
N-[(3S)-5-(5-fluoro-6-methoxypyridin-3-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C23H19F4N3O4
 1
1
IC50 = 3981.07 nM
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CP0452260
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
   Show/Hide
C23H21F3N4O4
 1
1
IC50 = 3981.07 nM
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CP0492729
N-[N'-(4-phenylbutyl)carbamimidoyl]naphthalene-1-carboxamide
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C22H23N3O
 1
1
IC50 = 4100 nM
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CP0409607
4-methyl-N-[N'-(2-propan-2-ylphenyl)carbamimidoyl]benzamide
   Show/Hide
C18H21N3O
 1
1
IC50 = 4500 nM
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CP0478841
[(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,8,9-tetrahydro-1H-pyrrolo[1,2-c]purin-4-yl]methyl acetate
   Show/Hide
C11H18N6O4
 1
1
IC50 = 4566 nM
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CP0377579
5-methyl-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-2-phenyltriazole-4-carboxamide
   Show/Hide
C24H28N6O2
 1
1
IC50 = 5011.87 nM
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CP0416296
N-[(3S)-5-(2-methylpyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
   Show/Hide
C22H19F3N4O3
 1
1
IC50 = 5011.87 nM
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CP0443557
N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
   Show/Hide
C23H27F3N4O3
 1
1
IC50 = 5011.87 nM
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CP0452263
N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
   Show/Hide
C22H25F3N4O3
 1
1
IC50 = 5011.87 nM
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CP0452265
N-[(3S)-5-[6-(hydroxymethyl)-5-methylpyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyridine-3-carboxamide
   Show/Hide
C26H26F3N3O5
 1
1
IC50 = 5011.87 nM
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CP0454740
4-methyl-N-[N'-(3-phenylpropyl)carbamimidoyl]benzamide
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C18H21N3O
 1
1
IC50 = 5250 nM
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CP0427278
2,6-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
 1
1
IC50 = 5400 nM
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CP0453499
4-methyl-N-[N'-(3-phenoxypropyl)carbamimidoyl]benzamide
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C18H21N3O2
 1
1
IC50 = 5600 nM
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CP0526927
4-methyl-N-[N'-(2-phenylethyl)carbamimidoyl]benzamide
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C17H19N3O
 1
1
IC50 = 5650 nM
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CP0501921
4-methyl-N-[N'-(4-propan-2-yloxyphenyl)carbamimidoyl]benzamide
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C18H21N3O2
 1
1
IC50 = 5750 nM
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CP0076201
N-[(3S)-5-[6-(hydroxymethyl)pyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C23H20F3N3O4
 1
1
IC50 = 6309.57 nM
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CP0416293
N-[(3S)-5-[2-(hydroxymethyl)pyridin-4-yl]-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
   Show/Hide
C23H20F3N3O4
 1
1
IC50 = 6309.57 nM
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CP0416295
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
   Show/Hide
C22H19F3N4O4
 1
1
IC50 = 6309.57 nM
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CP0441744
2,5-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
 1
1
IC50 = 7890 nM
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CP0448195
N-[N'-(4-phenylbutyl)carbamimidoyl]furan-2-carboxamide
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C16H19N3O2
 1
1
IC50 = 7900 nM
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CP0443558
N-[(3S)-5-[6-(hydroxymethyl)pyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyridine-3-carboxamide
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C25H24F3N3O5
 1
1
IC50 = 7943.28 nM
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CP0430923
N-[N'-[2-(4-chlorophenyl)ethyl]carbamimidoyl]-4-methylbenzamide
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C17H18ClN3O
 1
1
IC50 = 8500 nM
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CP0497887
4-methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]benzamide
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C20H19N3O
 1
1
IC50 = 8850 nM
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CP0381027
N-(N'-butylcarbamimidoyl)-4-methylbenzamide
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C13H19N3O
 1
1
IC50 = 9000 nM
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CP0406161
4-methyl-N-[N'-methyl-N-(4-phenylbutyl)carbamimidoyl]benzamide
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C20H25N3O
 1
1
IC50 = 9000 nM
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CP0377577
N-[(3S)-5-[6-(1-hydroxyethyl)pyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyridine-3-carboxamide
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C26H26F3N3O5
 1
1
IC50 = 10000 nM
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CP0433781
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide
   Show/Hide
C23H21F3N4O4
 1
1
IC50 = 10000 nM
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CP0400789
(5-chloro-1-methylindol-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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C22H24ClN3O
 1
1
IC50 = 10300 nM
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CP0430694
4-methyl-N-[N'-(2-thiophen-2-ylethyl)carbamimidoyl]benzamide
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C15H17N3OS
 1
1
IC50 = 10500 nM
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CP0383088
N-[N'-(2-benzylsulfanylethyl)carbamimidoyl]-4-methylbenzamide
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C18H21N3OS
 1
1
IC50 = 10800 nM
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CP0062157
N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide
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C23H21F3N4O4
 1
1
IC50 = 12589.25 nM
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CP0383545
4-methyl-N-[N'-(2-phenoxyethyl)carbamimidoyl]benzamide
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C17H19N3O2
 1
1
IC50 = 14200 nM
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CP0524330
3,4-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
 1
1
IC50 = 15500 nM
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CP0430911
4-methyl-N-[N'-(4-propan-2-ylphenyl)carbamimidoyl]benzamide
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C18H21N3O
 1
1
IC50 = 19700 nM
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CP0377582
N-[(3S)-5-(5-methylpyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide
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C23H21F3N4O3
 1
1
IC50 = 19952.62 nM
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CP0508613
4-methyl-N-[N'-(3,4,5-trimethoxyphenyl)carbamimidoyl]benzamide
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C18H21N3O4
 1
1
IC50 = 24350 nM
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CP0523038
N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
   Show/Hide
C22H19F3N4O4
 1
1
IC50 > 25118.86 nM
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CP0271660
(R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxy-phenyl)-2-imidazolidinone
   Show/Hide
C20H25N3O5S
 1
1
IC50 > 30000 nM
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CP0163715
5-chloro-4-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1H-pyridazin-6-one
   Show/Hide
C16H14ClF3N4O2
 1
1
IC50 > 30000 nM
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CP0372478
N-[(5-chloro-6-oxo-1H-pyridin-3-yl)-(4-fluorophenyl)methyl]-2-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamide
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C31H29ClF4N4O2
 1
1
IC50 > 31600 nM
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CP0436279
2-(2-methoxyethyl)-5-methyl-N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
   Show/Hide
C21H23N5O3
 1
1
IC50 > 31622.78 nM
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CP0437804
5-methyl-2-phenyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C24H21N5O2
 1
1
IC50 > 31622.78 nM
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CP0439895
2-(2-methoxyethyl)-5-methyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C21H23N5O3
 1
1
IC50 > 31622.78 nM
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CP0452261
5-methyl-2-(2-methylpropyl)-N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C22H25N5O2
 1
1
IC50 > 31622.78 nM
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CP0010753
N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)piperidin-4-yl]methyl]-3,5-dichlorobenzamide
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C21H32Cl2N4O3
 1
1
IC50 > 33000 nM
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CP0053278
(5-bromo-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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C21H23BrN4O
 1
1
IC50 > 33000 nM
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CP0094025
(5-chloro-1-methylindol-2-yl)-[6-[(dimethylamino)methyl]-7-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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C23H26ClN3O
 1
1
IC50 > 33000 nM
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CP0381028
N-(2,3-dihydroindole-1-carboximidoyl)-4-methylbenzamide
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C17H17N3O
 1
1
IC50 > 100000 nM
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CP0436278
N-[(3S)-5-(5-methylpyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H19F3N4O3
 1
1
IC50 > 3162.28 nM
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CP0637108
rac-1-(2-(2-hydroxy-3-(4-p-tolylpiperazin-1-yl)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride
   Show/Hide
C29H35ClN2O3
 1
1
IC50 > 5000 nM
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CP0636848
rac-1-(2-(2-hydroxy-3-(4-phenylpiperidin-1-yl)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride
   Show/Hide
C29H34ClNO3
 1
1
IC50 > 5000 nM
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CP0637784
rac-1-(2-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy)-5-fluorophenyl)-3-phenylpropan-1-one hydrochloride
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C35H38ClFN2O3
 1
1
IC50 > 5000 nM
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CP0443560
4-butoxy-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]benzamide
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C25H33N3O3
 1
1
IC50 > 6309.57 nM
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