Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01070 , C-C chemokine receptor type 1
Gene Name CCR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P32246
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01070
 
Compound ID Compound Name Compound Formula
CP0131315
1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9H-xanthene-9-carbonyl)-amino]-1-ethyl-piperidinium; iodide
   Show/Hide
C30H37Cl2IN2O2
 1
1
IC50 = 0.9 nM
   TI
   LI
   LO
   TS
CP0377804
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(3-hydroxy-propyl)-urea
   Show/Hide
C32H40ClN3O3
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0454737
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(2-dimethylamino-ethyl)-urea
   Show/Hide
C33H43ClN4O2
 1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CP0434605
1-tert-Butyl-3-{5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-urea
   Show/Hide
C33H42ClN3O2
 1
1
IC50 = 71 nM
   TI
   LI
   LO
   TS
CP0528916
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-cyclohexylmethyl-urea
   Show/Hide
C36H46ClN3O2
 1
1
IC50 = 125 nM
   TI
   LI
   LO
   TS
CP0438433
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-pyridin-4-yl-urea
   Show/Hide
C34H37ClN4O2
 1
1
IC50 = 167 nM
   TI
   LI
   LO
   TS
CP0495894
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(4-hydroxy-butyl)-urea
   Show/Hide
C33H42ClN3O3
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0376961
2-(Benzothiazol-2-ylsulfanyl)-N-[1-(4-chloro-benzyl)-piperidin-4-yl]-acetamide
   Show/Hide
C21H22ClN3OS2
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0403530
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-[2-(4-fluoro-phenyl)-ethyl]-urea
   Show/Hide
C37H41ClFN3O2
 1
1
IC50 = 295 nM
   TI
   LI
   LO
   TS
CP0448851
1-(1-Benzyl-piperidin-4-yl)-3-{5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-urea
   Show/Hide
C41H49ClN4O2
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0373271
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(2-piperidin-1-yl-ethyl)-urea
   Show/Hide
C36H47ClN4O2
 1
1
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0085008
2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide
   Show/Hide
C21H21Cl2N3OS2
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0479827
4-(3-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-ureido)-piperidine-1-carboxylic acid methyl ester
   Show/Hide
C36H45ClN4O4
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0149004
5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile
   Show/Hide
C28H29ClN2O
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0522231
1-(5-Amino-4,4-diphenyl-pentyl)-4-(4-chloro-phenyl)-piperidin-4-ol
   Show/Hide
C28H33ClN2O
 1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS
CP0438827
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(4-methoxy-phenyl)-urea
   Show/Hide
C36H40ClN3O3
 1
1
IC50 = 780 nM
   TI
   LI
   LO
   TS
CP0476971
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(4-trifluoromethyl-phenyl)-urea
   Show/Hide
C36H37ClF3N3O2
 1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
CP0377866
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(2,5-difluoro-phenyl)-urea
   Show/Hide
C35H36ClF2N3O2
 1
1
IC50 = 1340 nM
   TI
   LI
   LO
   TS
CP0395200
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(3-trifluoromethyl-phenyl)-urea
   Show/Hide
C36H37ClF3N3O2
 1
1
IC50 = 1410 nM
   TI
   LI
   LO
   TS
CP0228253
2-(6-Amino-benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide
   Show/Hide
C21H22Cl2N4OS2
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0431303
N-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-2-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]acetamide
   Show/Hide
C23H25Cl2N3O2S2
 1
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0499483
2-(Benzothiazol-2-ylsulfanyl)-N-(1-benzyl-piperidin-3-ylmethyl)-acetamide
   Show/Hide
C22H25N3OS2
 1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0393456
2-(Benzothiazol-2-ylsulfanyl)-N-(1-benzyl-piperidin-4-yl)-acetamide
   Show/Hide
C21H23N3OS2
 1
1
IC50 = 7100 nM
   TI
   LI
   LO
   TS
CP0430863
2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3-chloro-benzyl)-piperidin-4-yl]-acetamide
   Show/Hide
C21H22ClN3OS2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0515799
2-{[1-(3,4-Dichloro-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-benzothiazole-6-carboxylic acid ethyl ester
   Show/Hide
C24H25Cl2N3O3S2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0376365
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(4-methoxy-phenyl)-urea
   Show/Hide
C27H31N3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0380249
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(1H-indazol-6-yl)-urea
   Show/Hide
C27H29N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0383417
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(3-methoxy-phenyl)-urea
   Show/Hide
C27H31N3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0389821
1-{2-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-phenyl}-3-(3-cyano-phenyl)-urea
   Show/Hide
C28H30N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0402897
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(3-hydroxy-propyl)-urea
   Show/Hide
C23H31N3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0405256
1-Benzyl-3-[2-(4-benzyl-piperidin-1-ylmethyl)-phenyl]-urea
   Show/Hide
C27H31N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0438432
1-{2-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-ethyl]-phenyl}-3-(3-cyano-phenyl)-urea
   Show/Hide
C28H30N4O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0438500
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-phenyl-urea
   Show/Hide
C26H29N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0448842
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(1H-indazol-5-yl)-urea
   Show/Hide
C27H29N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0448903
1-{2-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-ethyl]-phenyl}-3-(2,5-difluoro-phenyl)-urea
   Show/Hide
C27H29F2N3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0461057
1-{2-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-ethyl]-phenyl}-3-(3-methoxy-phenyl)-urea
   Show/Hide
C28H33N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0463755
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(3-cyano-phenyl)-urea
   Show/Hide
C27H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0493942
1-{2-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-phenyl}-3-(3-methoxy-phenyl)-urea
   Show/Hide
C28H33N3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0871032
CENICRIVIROC MESYLATE
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C42H56N4O7S2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0086294
4-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]pyridine-2-carboxamide
   Show/Hide
C24H23F3N4O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0396564
6-[[1-(4-methylphenyl)sulfonylpiperidin-4-yl]amino]pyridine-3-carbonitrile
   Show/Hide
C18H20N4O2S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0416486
6-[[1-(4-phenylphenyl)sulfonylpiperidin-4-yl]amino]pyridine-3-carbonitrile
   Show/Hide
C23H22N4O2S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0416487
5-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]pyridine-2-carboxamide
   Show/Hide
C24H23F3N4O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0416488
4-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]benzamide
   Show/Hide
C25H24F3N3O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0457807
4-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]benzonitrile
   Show/Hide
C25H22F3N3O2S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0218739
4-Benzyl-1-(4-phenyl-butyl)-piperidine
   Show/Hide
C22H29N
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0268787
4-Benzyl-1-phenethyl-piperidine
   Show/Hide
C20H25N
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0372694
5-(4-Benzyl-piperidin-1-yl)-2,2-diphenyl-pentanenitrile
   Show/Hide
C29H32N2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0374740
5-(4-Benzyl-piperazin-1-yl)-2,2-diphenyl-pentanenitrile
   Show/Hide
C28H31N3
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0424962
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(2,5-difluoro-phenyl)-urea
   Show/Hide
C26H27F2N3O
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0460734
1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(2-piperidin-1-yl-ethyl)-urea
   Show/Hide
C27H38N4O
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0465469
1-(1-Benzyl-piperidin-4-yl)-3-[2-(4-benzyl-piperidin-1-ylmethyl)-phenyl]-urea
   Show/Hide
C32H40N4O
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0545278
1,4-Dibenzyl-piperidine
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C19H23N
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0374727
1-Benzyl-3-{5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-urea
   Show/Hide
C36H40ClN3O2
 1
1
IC50 < 780 nM
   TI
   LI
   LO
   TS
CP0383392
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-methyl-urea
   Show/Hide
C30H36ClN3O2
 1
1
IC50 < 780 nM
   TI
   LI
   LO
   TS
CP0424944
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-phenyl-urea
   Show/Hide
C35H38ClN3O2
 1
1
IC50 < 780 nM
   TI
   LI
   LO
   TS
CP0479823
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-isopropyl-urea
   Show/Hide
C32H40ClN3O2
 1
1
IC50 < 780 nM
   TI
   LI
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   TS