Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT03661 , ATP-sensitive inward rectifier potassium channel 1
 Protein Info 
Gene Name KCNJ1
Organism Rattus norvegicus, Rat
Protein Classification Ion channel
Uniprot ID P35560
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006
 Cell Line Info 
 Protein ID: PT03661
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0260361
 Compound Info 
US9206198, 7
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C24H28N2O6
  1
1
IC50 = 2.8 nM
 Bioactivity Info 
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CP0309069
 Compound Info 
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
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C24H28N4O5
  1
1
IC50 = 38 nM
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CP0051541
 Compound Info 
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one
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C25H29N3O6S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0441184
 Compound Info 
5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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C24H30N4O5S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0117618
 Compound Info 
2-fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
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C23H24FN3O2
  1
1
IC50 = 55 nM
 Bioactivity Info 
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CP0046632
 Compound Info 
US9056859, 72
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C23H25N7O3
  1
1
IC50 = 56 nM
 Bioactivity Info 
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CP0051539
 Compound Info 
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one
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C24H28N4O6S
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0414064
 Compound Info 
5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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C25H31N3O5S
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0447983
 Compound Info 
4-methyl-5-[2-[4-[2-[2-methyl-6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C24H27N7O3
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0452651
 Compound Info 
5-[2-[4-fluoro-1-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
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C24H24FN5O3
  1
1
IC50 = 73 nM
 Bioactivity Info 
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CP0108552
 Compound Info 
4-methyl-5-[2-[4-[2-[3-methyl-5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C24H27N7O3
  1
1
IC50 = 79 nM
 Bioactivity Info 
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CP0459494
 Compound Info 
5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C22H23N7O3
  1
1
IC50 = 86 nM
 Bioactivity Info 
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CP0420173
 Compound Info 
5-[2-[1-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
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C23H24N6O3
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0401750
 Compound Info 
4-methyl-5-[2-[1-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
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C25H27N5O3
  1
1
IC50 = 140 nM
 Bioactivity Info 
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CP0475598
 Compound Info 
4-methyl-5-[2-[4-[2-[5-(tetrazol-1-yl)pyrazin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C22H24N8O3
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0542155
 Compound Info 
5-[(E)-2-[1-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperidin-4-yl]ethenyl]-3H-2-benzofuran-1-one
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C24H23N5O3
  1
1
IC50 = 180 nM
 Bioactivity Info 
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CP0095971
 Compound Info 
4-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C24H26N6O3
  1
1
IC50 = 190 nM
 Bioactivity Info 
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CP0376890
 Compound Info 
5-[1-fluoro-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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C23H24FN7O3
  1
1
IC50 = 220 nM
 Bioactivity Info 
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CP0459499
 Compound Info 
5-[2-[1-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
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C24H25N5O3
  1
1
IC50 = 220 nM
 Bioactivity Info 
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CP0402899
 Compound Info 
5-[2-[4-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C22H23N7O3
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0389764
 Compound Info 
5-[(1R)-1-hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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C25H31N3O5S
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0407482
 Compound Info 
4-methyl-5-[2-[4-[2-[4-methyl-6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C24H27N7O3
  1
1
IC50 = 257 nM
 Bioactivity Info 
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CP0358870
 Compound Info 
4-methyl-5-[1-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]propan-2-yl]-3H-2-benzofuran-1-one
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C24H27N7O3
  1
1
IC50 = 270 nM
 Bioactivity Info 
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CP0376888
 Compound Info 
4-methyl-5-[2-[4-[2-[2-methyl-6-(tetrazol-1-yl)pyridin-3-yl]propanoyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C25H29N7O3
  1
1
IC50 = 430 nM
 Bioactivity Info 
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CP0409655
 Compound Info 
4-methyl-5-[2-[4-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C23H25N7O3
  1
1
IC50 = 580 nM
 Bioactivity Info 
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CP0402898
 Compound Info 
5-[2-[3-[2-[4-(tetrazol-1-yl)phenyl]acetyl]-3-azabicyclo[3.1.0]hexan-6-yl]ethyl]-3H-2-benzofuran-1-one
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C24H23N5O3
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0376889
 Compound Info 
4-methyl-5-[2-[4-[2-[5-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C23H25N7O3
  1
1
IC50 = 630 nM
 Bioactivity Info 
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CP0481337
 Compound Info 
5-[1-hydroxy-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methoxy-3H-2-benzofuran-1-one
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C23H25N7O5
  1
1
IC50 = 630 nM
 Bioactivity Info 
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CP0376891
 Compound Info 
5-[1-hydroxy-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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C23H25N7O4
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0409657
 Compound Info 
5-[1-methoxy-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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C24H27N7O4
  1
1
IC50 = 2200 nM
 Bioactivity Info 
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CP0409961
 Compound Info 
5-[2-[4-hydroxy-1-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
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C24H25N5O4
  1
1
IC50 = 3100 nM
 Bioactivity Info 
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CP0402900
 Compound Info 
2-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-7H-furo[3,4-b]pyridin-5-one
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C22H23N7O3
  1
1
IC50 = 3700 nM
 Bioactivity Info 
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CP0414598
 Compound Info 
4-methyl-5-[2-[4-[2-[4-methyl-6-(tetrazol-1-yl)pyridin-3-yl]propanoyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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C25H29N7O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0542156
 Compound Info 
5-[2-[1-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
   Show/Hide
C23H24N6O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0459496
 Compound Info 
6-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-1H-furo[3,4-c]pyridin-3-one
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C22H23N7O3
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0402727
 Compound Info 
3-[(4-chlorophenyl)sulfamoyl]-4-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]benzamide
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C18H17ClN4O4S
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0402728
 Compound Info 
4-methyl-N-[(1-methyltriazol-4-yl)methyl]-3-[[4-(1,2-oxazol-5-yl)phenyl]sulfamoyl]benzamide
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C21H20N6O4S
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0416450
 Compound Info 
3-[(4-chlorophenyl)sulfamoyl]-4-methoxy-N-[1-(2-methyltriazol-4-yl)ethyl]benzamide
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C19H20ClN5O4S
  1
1
IC50 > 30000 nM
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