General Information of the Compound
Compound ID
CP0409657
Compound Name
5-[1-methoxy-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
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Structure
Formula
C24H27N7O4
Molecular Weight
477.525
Canonical SMILES
COC(CN1CCN(CC1)C(=O)Cc1ccc(nc1)-n1cnnn1)c1ccc2C(=O)OCc2c1C
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InChI
InChI=1S/C24H27N7O4/c1-16-18(4-5-19-20(16)14-35-24(19)33)21(34-2)13-29-7-9-30(10-8-29)23(32)11-17-3-6-22(25-12-17)31-15-26-27-28-31/h3-6,12,15,21H,7-11,13-14H2,1-2H3
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InChIKey
ISRDPDAMWUGJKM-UHFFFAOYSA-N
Physicochemical Property
logP
1.11052
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
115.57
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68094634
ChEMBL ID
CHEMBL3792808
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03661, ATP-sensitive inward rectifier potassium channel 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS