General Information of the Compound
Compound ID
CP0414598
Compound Name
4-methyl-5-[2-[4-[2-[4-methyl-6-(tetrazol-1-yl)pyridin-3-yl]propanoyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
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Structure
Formula
C25H29N7O3
Molecular Weight
475.553
Canonical SMILES
CC(C(=O)N1CCN(CCc2ccc3C(=O)OCc3c2C)CC1)c1cnc(cc1C)-n1cnnn1
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InChI
InChI=1S/C25H29N7O3/c1-16-12-23(32-15-27-28-29-32)26-13-21(16)18(3)24(33)31-10-8-30(9-11-31)7-6-19-4-5-20-22(17(19)2)14-35-25(20)34/h4-5,12-13,15,18H,6-11,14H2,1-3H3
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InChIKey
BUKUMBXSVUEGRL-UHFFFAOYSA-N
Physicochemical Property
logP
1.83494
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
106.34
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127028816
ChEMBL ID
CHEMBL3793717
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03661, ATP-sensitive inward rectifier potassium channel 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 42000 nM
   TI
   LI
   LO
   TS