General Information of the Compound
Compound ID
CP0402900
Compound Name
2-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-7H-furo[3,4-b]pyridin-5-one
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Structure
Formula
C22H23N7O3
Molecular Weight
433.472
Canonical SMILES
O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3n2)CC1
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InChI
InChI=1S/C22H23N7O3/c30-21(13-16-1-4-18(5-2-16)29-15-23-25-26-29)28-11-9-27(10-12-28)8-7-17-3-6-19-20(24-17)14-32-22(19)31/h1-6,15H,7-14H2
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InChIKey
FGHSCDNBUBHJFB-UHFFFAOYSA-N
Physicochemical Property
logP
0.6571
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
106.34
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127030626
ChEMBL ID
CHEMBL3794101
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03661, ATP-sensitive inward rectifier potassium channel 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 26000 nM
   TI
   LI
   LO
   TS