Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01975 , Cyclin-dependent kinase 8
Gene Name CDK8
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P49336
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01975
 
Compound ID Compound Name Compound Formula
CP0530104
3-amino-4-[4-[4-(dimethylamino)-4-oxobutyl]-2-fluorophenoxy]-6-methylthieno[2,3-b]pyridine-2-carboxamide
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C21H23FN4O3S
 1
1
IC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0033552
[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]-pyrrolidin-1-ylmethanone
   Show/Hide
C23H23N5O
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0022961
(3-methoxyazetidin-1-yl)-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone
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C23H23N5O2
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0003010
[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]-morpholin-4-ylmethanone
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C23H23N5O2
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0016543
[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]-piperidin-1-ylmethanone
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C24H25N5O
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0017801
(3-methoxyazetidin-1-yl)-[3-[(1-methylindazol-5-yl)methyl]-2H-indazol-5-yl]methanone
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C21H21N5O2
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0018399
(3,3-difluoroazetidin-1-yl)-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone
   Show/Hide
C22H19F2N5O
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0031406
(3,3-difluoropyrrolidin-1-yl)-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone
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C23H21F2N5O
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0344230
US11471446, Compound DBA-6
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C19H21N5OS
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0575311
3-amino-4-(3-methylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide
   Show/Hide
C14H18N4OS
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0549319
5-amino-4-[3-(propoxymethyl)piperidin-1-yl]-7H-cyclopenta[b]pyridine-6-carboxamide
   Show/Hide
C18H26N4O2
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0577909
3-amino-4-[(3S)-3-(2-ethoxyethoxymethyl)piperidin-1-yl]thieno[2,3-b]pyridine-2-carboxamide
   Show/Hide
C18H26N4O3S
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0577882
3-amino-4-[(3S)-3-(methoxymethyl)piperidin-1-yl]thieno[2,3-b]pyridine-2-carboxamide
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C15H20N4O2S
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0000516
[(3R)-3-hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone
   Show/Hide
C23H23N5O2
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0021297
[(3S)-3-hydroxypyrrolidin-1-yl]-[3-[(1-methylindazol-5-yl)methyl]-2H-indazol-5-yl]methanone
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C21H21N5O2
 1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0022292
[(3S)-3-hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone
   Show/Hide
C23H23N5O2
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0016840
N-methyl-3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazole-5-carboxamide
   Show/Hide
C20H19N5O
 1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
CP0021298
(3,3-difluoropyrrolidin-1-yl)-[3-[(1-methylindazol-5-yl)methyl]-2H-indazol-5-yl]methanone
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C21H19F2N5O
 1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
CP0001577
N-methyl-3-[(1-methylindazol-5-yl)methyl]-2H-indazole-5-carboxamide
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C18H17N5O
 1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CP0033570
3-[[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]methyl]-N-methyl-2H-indazole-5-carboxamide
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C23H25N5O2
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0022290
1-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]pyrrolidin-2-one
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C22H21N5O
 1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CP0571531
3-amino-4-[3-(hydroxymethyl)piperidin-1-yl]thieno[2,3-b]pyridine-2-carboxamide
   Show/Hide
C14H18N4O2S
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0030145
(3-hydroxyazetidin-1-yl)-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone
   Show/Hide
C22H21N5O2
 1
1
IC50 = 94 nM
   TI
   LI
   LO
   TS
CP0027714
N-cyclopropyl-3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazole-5-carboxamide
   Show/Hide
C22H21N5O
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0031512
N-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]acetamide
   Show/Hide
C20H19N5O
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0273632
3-amino-4-piperidin-1-ylthieno[2,3-b]pyridine-2-carboxamide
   Show/Hide
C13H16N4OS
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0017865
[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]-piperazin-1-ylmethanone
   Show/Hide
C23H24N6O
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0019302
(3-hydroxyazetidin-1-yl)-[3-[(1-methylindazol-5-yl)methyl]-2H-indazol-5-yl]methanone
   Show/Hide
C20H19N5O2
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0015868
5-(1-methylimidazol-4-yl)-3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazole
   Show/Hide
C22H20N6
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0018970
3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazole-5-carboxamide
   Show/Hide
C19H17N5O
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0016841
N-cyclopropyl-3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazole-5-sulfonamide
   Show/Hide
C21H21N5O2S
 1
1
IC50 = 313 nM
   TI
   LI
   LO
   TS
CP0575727
3-amino-4-[(3R)-3-(methoxymethyl)piperidin-1-yl]thieno[2,3-b]pyridine-2-carboxamide
   Show/Hide
C15H20N4O2S
 1
1
IC50 = 410 nM
   TI
   LI
   LO
   TS
CP0543015
3-amino-4-(4-methylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide
   Show/Hide
C14H18N4OS
 1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0017443
N-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanesulfonamide
   Show/Hide
C19H19N5O2S
 1
1
IC50 = 710 nM
   TI
   LI
   LO
   TS
CP0033410
2-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]pyridin-4-amine
   Show/Hide
C23H20N6
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0016959
5-(1-methylimidazol-2-yl)-3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazole
   Show/Hide
C22H20N6
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0029639
N-methyl-3-[(3-methylphenyl)methyl]-2H-indazole-5-carboxamide
   Show/Hide
C17H17N3O
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0017464
N-methyl-3-[(1-methylindazol-6-yl)methyl]-2H-indazole-5-carboxamide
   Show/Hide
C18H17N5O
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0022291
N-[2-[[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]amino]ethyl]acetamide
   Show/Hide
C22H24N6O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0022311
N-methyl-3-(2-methylpropyl)-2H-indazole-5-carboxamide
   Show/Hide
C13H17N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0022668
3-[(3,4-dimethoxyphenyl)methyl]-N-methyl-2H-indazole-5-carboxamide
   Show/Hide
C18H19N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0032193
4-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]morpholine
   Show/Hide
C22H23N5O
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS