| Compound ID |
Compound Name |
Compound Formula |
|
CP0111826
|
1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
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|
C25H29N3O3
|
5
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
| 3 |
IC50 = 12 nM
|
|
|
| 4 |
IC50 = 16 nM
|
|
|
| 5 |
IC50 = 45 nM
|
|
|
|
CP0579443
|
3-amino-N-(4-hydroxycyclohexyl)-6-[4-[(4-propan-2-ylpiperazin-1-yl)methyl]phenyl]pyrazine-2-carboxamide
Show/Hide
|
C25H36N6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0337570
|
3-(4-piperazin-1-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine-4-carbonitrile
Show/Hide
|
C25H26N4O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0204821
|
2,6-dimethoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide
Show/Hide
|
C28H34N4O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0143999
|
2,6-dimethoxy-4-[4-methyl-5-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0232967
|
4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine
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|
C27H32N2O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0096946
|
4-methyl-3-(4-piperidin-4-yloxyphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine
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|
C26H30N2O4
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0329734
|
1-[4-[4-fluoro-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
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|
C24H26FN3O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0577106
|
3-amino-6-[4-[(4-propan-2-ylpiperazin-1-yl)methyl]phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C23H31F3N6O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0163624
|
(3R,5S)-3,5-dimethyl-1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
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|
C27H33N3O3
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0572569
|
3-amino-6-[4-[[4-(diethylamino)piperidin-1-yl]methyl]phenyl]-N-(4-hydroxycyclohexyl)pyrazine-2-carboxamide
Show/Hide
|
C27H40N6O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0572653
|
3-amino-6-[2-chloro-4-[(4-morpholin-4-ylpiperidin-1-yl)methyl]phenyl]-N-(4-hydroxy-1-bicyclo[2.2.2]octanyl)pyrazine-2-carboxamide
Show/Hide
|
C29H39ClN6O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0367669
|
4-methyl-3-[4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine
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|
C26H28N2O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0578701
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-(2-hydroxycyclopentyl)pyrazine-2-carboxamide
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|
C19H25N5O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0258427
|
3-(4-fluoro-3,5-dimethoxyphenyl)-5-(4-piperazin-1-ylphenyl)pyridine-4-carbonitrile
Show/Hide
|
C24H23FN4O2
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0572899
|
3-amino-N-cyclohexyl-6-[4-[(dimethylamino)methyl]phenyl]pyrazine-2-carboxamide
Show/Hide
|
C20H27N5O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0125897
|
2-fluoro-6-methoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide
Show/Hide
|
C27H31FN4O2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0143995
|
2,6-dimethoxy-4-[4-methyl-5-[4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]phenyl]pyridin-3-yl]benzamide
Show/Hide
|
C28H34N4O3
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0163625
|
4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine
Show/Hide
|
C26H30N2O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0125900
|
2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C24H26N4O2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0561826
|
1-methyl-4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0232965
|
1-[4-[4-chloro-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C24H26ClN3O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0516506
|
1-methylsulfonyl-4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C26H31N3O5S
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0572570
|
3-amino-N-(4-hydroxycyclohexyl)-6-[4-[(4-morpholin-4-ylpiperidin-1-yl)methyl]phenyl]pyrazine-2-carboxamide
Show/Hide
|
C27H38N6O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0564416
|
4-methyl-3-[4-(1-methylpiperidin-4-yl)oxyphenyl]-5-(3,4,5-trimethoxyphenyl)pyridine
Show/Hide
|
C27H32N2O4
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0121895
|
1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]-4-propan-2-ylpiperazine
Show/Hide
|
C28H35N3O3
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0204819
|
2-fluoro-6-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C24H25FN4O2
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0571733
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C18H22F3N5O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0330124
|
1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]-1,4-diazepane
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0573938
|
3-amino-6-[2-chloro-4-[(4-morpholin-4-ylpiperidin-1-yl)methyl]phenyl]-N-(4-hydroxycyclohexyl)pyrazine-2-carboxamide
Show/Hide
|
C27H37ClN6O3
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0125898
|
2-fluoro-6-methoxy-4-[4-methyl-5-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide
Show/Hide
|
C25H27FN4O2
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0250231
|
2-chloro-6-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C24H25ClN4O2
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0232970
|
1-[4-[5-(4-fluoro-3,5-dimethoxyphenyl)-4-methylpyridin-3-yl]phenyl]piperazine
Show/Hide
|
C24H26FN3O2
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0125896
|
2-fluoro-6-methoxy-4-[4-methyl-5-[4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]phenyl]pyridin-3-yl]benzamide
Show/Hide
|
C27H31FN4O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0525937
|
4-methyl-3-[4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine
Show/Hide
|
C27H30N2O3
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0163626
|
1-methyl-4-[[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]methyl]piperazine
Show/Hide
|
C27H33N3O3
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
|
CP0580164
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-(4-hydroxycyclohexyl)pyrazine-2-carboxamide
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0351989
|
N,N-dimethyl-4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine-1-carboxamide
Show/Hide
|
C28H34N4O4
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0579947
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-propan-2-ylpyrazine-2-carboxamide
Show/Hide
|
C17H23N5O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0258425
|
1-[4-[4-cyclopropyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C27H31N3O3
|
1
|
| 1 |
IC50 = 159 nM
|
|
|
|
CP0330123
|
4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]-1,4-thiazinane 1,1-dioxide
Show/Hide
|
C25H28N2O5S
|
1
|
| 1 |
IC50 = 169 nM
|
|
|
|
CP0164881
|
2,6-dimethoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 178 nM
|
|
|
|
CP0258428
|
1-(2-fluoroethyl)-4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C27H32FN3O3
|
1
|
| 1 |
IC50 = 178 nM
|
|
|
|
CP0520843
|
1-[4-[4-(trifluoromethyl)-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C25H26F3N3O3
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
|
CP0577105
|
3-amino-6-[4-(diethylaminomethyl)phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C20H26F3N5O2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0571119
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-ethylpyrazine-2-carboxamide
Show/Hide
|
C16H21N5O
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0571120
|
3-amino-6-[4-(piperazin-1-ylmethyl)phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C20H25F3N6O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0580163
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-(2-hydroxypropyl)pyrazine-2-carboxamide
Show/Hide
|
C17H23N5O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0567778
|
1-[4-[4-methoxy-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C25H29N3O4
|
1
|
| 1 |
IC50 = 233 nM
|
|
|
|
CP0561825
|
3-(4-piperazin-1-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridin-4-amine
Show/Hide
|
C24H28N4O3
|
1
|
| 1 |
IC50 = 255 nM
|
|
|
|
CP0423902
|
1-[4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazin-1-yl]ethanone
Show/Hide
|
C27H31N3O4
|
1
|
| 1 |
IC50 = 267 nM
|
|
|
|
CP0578380
|
3-amino-6-[2-chloro-4-[(4-morpholin-4-ylpiperidin-1-yl)methyl]phenyl]-N-(4-hydroxy-4-methylcyclohexyl)pyrazine-2-carboxamide
Show/Hide
|
C28H39ClN6O3
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0409304
|
4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]morpholine
Show/Hide
|
C25H28N2O4
|
1
|
| 1 |
IC50 = 334 nM
|
|
|
|
CP0577743
|
3-amino-6-[4-(pyrrolidin-1-ylmethyl)phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C20H24F3N5O2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0569242
|
3-amino-6-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C20H24F3N5O4S
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0351988
|
1-[4-[5-(3,5-dimethoxyphenyl)-4-methylpyridin-3-yl]phenyl]piperazine
Show/Hide
|
C24H27N3O2
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0577904
|
3-amino-6-[4-[(dimethylamino)methyl]phenyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyrazine-2-carboxamide
Show/Hide
|
C17H20F3N5O2
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0545294
|
3-amino-6-[4-(morpholin-4-ylmethyl)phenyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]pyrazine-2-carboxamide
Show/Hide
|
C20H24F3N5O3
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0263439
|
3-methoxy-5-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C24H26N4O2
|
1
|
| 1 |
IC50 = 588 nM
|
|
|
|
CP0330120
|
1-[4-[4-ethyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 589 nM
|
|
|
|
CP0143997
|
2-methoxy-5-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C24H26N4O2
|
1
|
| 1 |
IC50 = 694 nM
|
|
|
|
CP0204820
|
2-fluoro-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C23H23FN4O
|
1
|
| 1 |
IC50 = 1013 nM
|
|
|
|
CP0158027
|
5-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2,3-dihydroisoindol-1-one
Show/Hide
|
C24H24N4O
|
1
|
| 1 |
IC50 = 2336 nM
|
|
|
|
CP0143993
|
4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C23H24N4O
|
1
|
| 1 |
IC50 = 2771 nM
|
|
|
|
CP0143994
|
3-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]thiophene-2-carboxamide
Show/Hide
|
C22H24N4O2S
|
1
|
| 1 |
IC50 = 2811 nM
|
|
|
|
CP0223091
|
3-methoxy-5-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]thiophene-2-carboxamide
Show/Hide
|
C22H24N4O2S
|
1
|
| 1 |
IC50 = 3371 nM
|
|
|
|
CP0143996
|
2-(methoxymethyl)-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C25H28N4O2
|
1
|
| 1 |
IC50 = 3845 nM
|
|
|
|
CP0064594
|
4-methoxy-5-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]thiophene-3-carboxamide
Show/Hide
|
C22H24N4O2S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0164880
|
2-methoxy-N-methyl-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C25H28N4O2
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0249538
|
2-methoxy-N,N-dimethyl-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
Show/Hide
|
C26H30N4O2
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
