Brief Information of the Compound and Protein
Compound Name
2-fluoro-6-methoxy-4-[4-methyl-5-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide
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PubChem ID
CID: 155564042
Canonical SMILES
COc1cc(cc(F)c1C(N)=O)-c1cncc(c1C)-c1ccc(cc1)N1CCN(C)CC1
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Compound Formula C25H27FN4O2
Compound Structure
Protein Name
Activin receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR1
Uniprot ID
Q04771
Gene Name
ACVR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
2 IC50 = 16 nM
3 IC50 = 17 nM
4 IC50 = 19 nM