Brief Information of the Compound and Protein
Compound Name
5-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2,3-dihydroisoindol-1-one
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PubChem ID
CID: 155564334
Canonical SMILES
Cc1c(cncc1-c1ccc2C(=O)NCc2c1)-c1ccc(cc1)N1CCNCC1
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Compound Formula C24H24N4O
Compound Structure
Protein Name
Activin receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR1
Uniprot ID
Q04771
Gene Name
ACVR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2336 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 171 nM
2 IC50 = 226 nM
3 IC50 = 363 nM
4 IC50 = 652 nM