Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01104 , Insulin-like growth factor 1 receptor
Gene Name IGF1R
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P08069
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01104
 
Compound ID Compound Name Compound Formula
CP0545871
1-(3-methoxy-4-phenoxyphenyl)-3-phenyl-1,3,5-triazinane-2,4,6-trione
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C22H17N3O5
 1
1
EC50 = 220 nM
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CP0537014
1-(3-methyl-4-phenoxyphenyl)-3-phenyl-1,3,5-triazinane-2,4,6-trione
   Show/Hide
C22H17N3O4
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0485950
1-(2-methoxy-4-phenoxyphenyl)-3-phenyl-1,3,5-triazinane-2,4,6-trione
   Show/Hide
C22H17N3O5
 1
1
EC50 = 270 nM
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   LI
   LO
   TS
CP0440109
1-(3-methoxyphenyl)-3-(4-phenoxyphenyl)-1,3,5-triazinane-2,4,6-trione
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C22H17N3O5
 1
1
EC50 = 840 nM
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   LI
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CP0485953
1-(4-phenoxyphenyl)-3-phenyl-1,3,5-triazinane-2,4,6-trione
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C21H15N3O4
 1
1
EC50 = 1800 nM
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CP0095983
(1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol
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C26H23N5O
 1
1
IC50 = 2.8 nM
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   TS
CP0386128
1-[4-[3-[4-amino-5-[2-fluoro-3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C29H35FN6O3
 1
1
IC50 = 2.8 nM
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   LI
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   TS
CP0283452
5-[2-fluoro-5-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C28H34FN5O3S
 1
1
IC50 = 8.9 nM
   TI
   LI
   LO
   TS
CP0112624
1-[4-[3-[4-amino-5-[3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C29H36N6O3
 1
1
IC50 = 10 nM
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   LI
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   TS
CP0122275
1-[4-[3-[4-amino-5-[2-fluoro-5-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C29H35FN6O3
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0029934
1-[4-[3-[4-amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C27H33FN6O3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0122274
5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C26H32FN5O3S
 1
1
IC50 = 14 nM
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   LI
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   TS
CP0029933
1-[4-[3-[4-amino-5-[2-fluoro-3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C27H33FN6O3
 1
1
IC50 = 16 nM
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   LI
   LO
   TS
CP0122276
5-[4-fluoro-3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C28H34FN5O3S
 1
1
IC50 = 31 nM
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   LI
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   TS
CP0488073
2-fluoro-6-{[2-({2-methoxy-5-methyl-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C28H33FN8O2
 1
1
IC50 = 38 nM
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CP0016788
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 9
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C28H32FN7O2
 1
1
IC50 = 47 nM
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CP0510158
4,5-difluoro-2-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H30F2N8O2
 1
1
IC50 = 53 nM
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   TS
CP0017667
7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C27H33N5O2
 1
1
IC50 = 53 nM
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   TS
CP0020296
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 25
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C27H31FN8O2
 1
1
IC50 = 60 nM
   TI
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CP0025678
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 8
   Show/Hide
C28H32FN7O2
 1
1
IC50 = 60 nM
   TI
   LI
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   TS
CP0356116
5-[3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C28H35N5O3S
 1
1
IC50 = 64 nM
   TI
   LI
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   TS
CP0526611
2-{[2-({5-chloro-2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluorobenzamide
   Show/Hide
C27H30ClFN8O2
 1
1
IC50 = 65 nM
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   TS
CP0029932
7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C27H29N5O
 1
1
IC50 = 65 nM
   TI
   LI
   LO
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CP0503001
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 12
   Show/Hide
C24H24FN7O3
 1
1
IC50 = 68 nM
   TI
   LI
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   TS
CP0435096
2-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H32N8O2
 1
1
IC50 = 71 nM
   TI
   LI
   LO
   TS
CP0423062
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 6
   Show/Hide
C28H30FN7O2
 1
1
IC50 = 82 nM
   TI
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   TS
CP0299598
2,4-difluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H30F2N8O2
 1
1
IC50 = 90 nM
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   TS
CP0435099
2-{[2-({2,5-dimethoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluorobenzamide
   Show/Hide
C28H33FN8O3
 1
1
IC50 = 90 nM
   TI
   LI
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   TS
CP0262632
2-[(2-{[2-methoxy-4-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
   Show/Hide
C28H31N7O2
 1
1
IC50 = 104 nM
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   LI
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CP0037058
2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H31FN8O2
 1
1
IC50 = 109 nM
   TI
   LI
   LO
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CP0510157
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 10
   Show/Hide
C27H31FN8O2
 1
1
IC50 = 122 nM
   TI
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   TS
CP0112623
[3-[4-amino-5-[3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]methanol
   Show/Hide
C24H28N4O3
 1
1
IC50 = 128 nM
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CP0336151
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 11
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C27H31FN8O2
 1
1
IC50 = 130 nM
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   TS
CP0463888
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 30
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C28H33FN8O2
 1
1
IC50 = 135 nM
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   LI
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   TS
CP0309657
1-[4-[3-[4-amino-5-[2-fluoro-5-[[(2R)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C27H33FN6O3
 1
1
IC50 = 159 nM
   TI
   LI
   LO
   TS
CP0070412
2-fluoro-6-{[2-({2-methoxy-5-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H31FN8O2
 1
1
IC50 = 160 nM
   TI
   LI
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   TS
CP0469667
[3-[4-amino-5-[3-[(4-methyl-7-oxabicyclo[2.2.1]heptan-1-yl)methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]methanol
   Show/Hide
C25H30N4O3
 1
1
IC50 = 183 nM
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   LI
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   TS
CP0386171
2-fluoro-6-{[2-({5-fluoro-2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H30F2N8O2
 1
1
IC50 = 190 nM
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   TS
CP0299597
2,3-difluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H30F2N8O2
 1
1
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0309656
5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C26H33N5O3S
 1
1
IC50 = 232 nM
   TI
   LI
   LO
   TS
CP0139071
2-fluoro-6-{[2-({2-methoxy-4-methyl-5-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C28H33FN8O2
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0158666
2-[(2-{[2-fluoro-4-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
   Show/Hide
C27H28FN7O
 1
1
IC50 = 317 nM
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   TS
CP0510159
2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-N-methylbenzamide
   Show/Hide
C28H33FN8O2
 1
1
IC50 = 370 nM
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   TS
CP0489779
2-fluoro-6-{[2-({3-fluoro-2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C27H30F2N8O2
 1
1
IC50 = 574 nM
   TI
   LI
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   TS
CP0503291
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 31
   Show/Hide
C27H31FN8O3
 1
1
IC50 = 613 nM
   TI
   LI
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CP0526613
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 33
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C29H35FN8O3
 1
1
IC50 = 650 nM
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CP0435091
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 34
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C30H37FN8O3
 1
1
IC50 = 760 nM
   TI
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   TS
CP0309851
5-[3-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C26H32FN5O3S
 1
1
IC50 = 1291 nM
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   TS
CP0531897
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 7
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C30H34FN7O2
 1
1
IC50 = 2240 nM
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CP0481506
2-fluoro-6-{[2-({2-methoxy-3-methyl-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
   Show/Hide
C28H33FN8O2
 1
1
IC50 = 3700 nM
   TI
   LI
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   TS
CP0026276
4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 32
   Show/Hide
C30H37FN8O4
 1
1
IC50 = 5600 nM
   TI
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   TS
CP0226079
5-[3-fluoro-5-[[(2R)-oxolan-2-yl]methoxy]phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C26H32FN5O3S
 1
1
IC50 = 5602 nM
   TI
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   TS
CP0526176
2-[(2-{[4-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-2-(trifluoromethyl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
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C28H28F3N7O
 1
1
IC50 > 10000 nM
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