Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10117858, Example 5
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 PubChem ID
CID: 58442344
Canonical SMILES
COc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F
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Compound Formula C12H13F6N3O3
Compound Structure
Protein Name
 Protein Info 
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
>
Other ion channel
>
Chloride channel
>
Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS
CL000259 FRT
 Cell Line Info 
Rattus norvegicus (Rat)  3
1
EC50 = 79 nM
   TI
   LI
   LO
   TS
2
EC50 = 113 nM
   TI
   LI
   LO
   TS
3
EC50 = 497 nM
   TI
   LI
   LO
   TS
CL000805 HBE1
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
2
EC50 = 72 nM
   TI
   LI
   LO
   TS