Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide
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 PubChem ID
CID: 58442366
Canonical SMILES
C[C@](O)(CNC(=O)c1nc(Br)c(cc1N)C(F)(F)F)C(F)(F)F
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Compound Formula C11H10BrF6N3O2
Compound Structure
Protein Name
 Protein Info 
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
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Other ion channel
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Chloride channel
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Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CL000259 FRT
 Cell Line Info 
Rattus norvegicus (Rat)  3
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
2
EC50 = 43 nM
   TI
   LI
   LO
   TS
3
EC50 = 150 nM
   TI
   LI
   LO
   TS
CL000805 HBE1
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS