Brief Information of the Compound and Protein
Compound Name
3-[(1R)-1-[[3-chloro-7-fluoro-6-[2-(2-hydroxypropan-2-yl)pyrimidin-5-yl]-2-methyl-1,5-naphthyridin-4-yl]amino]ethyl]-4-fluorobenzonitrile
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PubChem ID
CID: 126532303
Canonical SMILES
C[C@@H](Nc1c(Cl)c(C)nc2cc(F)c(nc12)-c1cnc(nc1)C(C)(C)O)c1cc(ccc1F)C#N
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Compound Formula C25H21ClF2N6O
Compound Structure
Protein Name
Tumor necrosis factor
Protein Classification
Secreted protein
Uniprot ID
P01375
Gene Name
TNF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000565 HEK-Blue CD40L Homo sapiens (Human)  1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CL000749 HUVEC-C Homo sapiens (Human)  1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS