Brief Information of the Compound and Protein
Compound Name
N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
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PubChem ID
CID: 3035905
SID: 14922586
Canonical SMILES
S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
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Compound Formula C15H24N4S
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T Homo sapiens (Human)  5
1
IC50 = 977 nM
   TI
   LI
   LO
   TS
2
Ki = 63 nM
   TI
   LI
   LO
   TS
3
Ki = 63.1 nM
   TI
   LI
   LO
   TS
4
Ki = 154.88 nM
   TI
   LI
   LO
   TS
5
Ki = 501.19 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  7
1
EC50 = 79.43 nM
   TI
   LI
   LO
   TS
2
IC50 = 489.78 nM
   TI
   LI
   LO
   TS
3
IC50 = 667 nM
   TI
   LI
   LO
   TS
4
Ki = 43 nM
   TI
   LI
   LO
   TS
5
Ki = 47.86 nM
   TI
   LI
   LO
   TS
6
Ki = 63.1 nM
   TI
   LI
   LO
   TS
7
Ki = 79 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA Homo sapiens (Human)  1
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
CL000903 HEK293-SF-hH4R-His6-CRE-Luc Homo sapiens (Human)  1
1
EC50 = 120.23 nM
   TI
   LI
   LO
   TS
CL000909 HEK293T-SF-His6-CRE-Luc Homo sapiens (Human)  1
1
Ki = 501.19 nM
   TI
   LI
   LO
   TS
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  8
1
EC50 = 70.79 nM
   TI
   LI
   LO
   TS
2
EC50 = 89.13 nM
   TI
   LI
   LO
   TS
3
EC50 = 109.65 nM
   TI
   LI
   LO
   TS
4
EC50 = 416.87 nM
   TI
   LI
   LO
   TS
5
Ki = 63.1 nM
   TI
   LI
   LO
   TS
6
Ki = 178 nM
   TI
   LI
   LO
   TS
7
Ki = 426.58 nM
   TI
   LI
   LO
   TS
8
Ki = 501.19 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC Homo sapiens (Human)  4
1
Ki = 125 nM
   TI
   LI
   LO
   TS
2
Ki = 125.89 nM
   TI
   LI
   LO
   TS
3
Ki = 328 nM
   TI
   LI
   LO
   TS
4
Ki = 501.19 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 3.981 nM
2 Ki = 27 nM
3 Ki = 124 nM
4 Ki = 125.89 nM