Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(-)-Pramipexole

Show/Hide

PubChem ID

CID: 119570

SID: 14748917

Canonical SMILES	CCCN[C@H]1CCc2nc(N)sc2C1 Show/Hide
Compound Formula	C10H17N3S

Compound Structure

Protein Name

Protein Info

D(3) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P35462

Gene Name

DRD3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	EC50 = 1 nM	TI LI LO TS
2	Ki = 0.7244 nM	TI LI LO TS
3	Ki = 0.88 nM	TI LI LO TS
4	Ki = 38 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 = 5.4 nM	TI LI LO TS
2	Ki = 2.78 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 0.8128 nM	TI LI LO TS
2	Kd = 0.0258 nM	TI LI LO TS
3	Ki = 0.6607 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	Ki = 0.94 nM	TI LI LO TS
2	Ki = 1.1 nM	TI LI LO TS
3	Ki = 1.32 nM	TI LI LO TS
4	Ki = 5.6 nM	TI LI LO TS
5	Ki = 8.2 nM	TI LI LO TS
6	Ki = 13 nM	TI LI LO TS
7	Ki = 17 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	ED50 = 3.7 nM	TI LI LO TS

Biochemical Assays