Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

3-HYDROXYTYRAMINE HYDROCHLORIDE

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PubChem ID

CID: 681

SID: 15170929

Canonical SMILES	NCCc1ccc(O)c(O)c1 Show/Hide
Compound Formula	C8H11NO2

Compound Structure

Protein Name

Protein Info

D(3) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P35462

Gene Name

DRD3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000367	AtT-20 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 8.53 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	8
1	EC50 = 4.76 nM	TI LI LO TS
2	EC50 = 5.34 nM	TI LI LO TS
3	EC50 = 5.8 nM	TI LI LO TS
4	EC50 = 7.26 nM	TI LI LO TS
5	EC50 = 7.64 nM	TI LI LO TS
6	EC50 = 8.57 nM	TI LI LO TS
7	EC50 = 10.6 nM	TI LI LO TS
8	Ki = 240 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 1.8 nM	TI LI LO TS
2	EC50 = 2.9 nM	TI LI LO TS
3	EC50 = 6.4 nM	TI LI LO TS
CL000153	CHOP Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 2.7 nM	TI LI LO TS
2	EC50 = 6.1 nM	TI LI LO TS
3	Ki = 20 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 0.11 nM	TI LI LO TS
2	EC50 = 0.8913 nM	TI LI LO TS
3	EC50 = 1.8 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	14
1	EC50 = 1.1 nM	TI LI LO TS
2	EC50 = 2.1 nM	TI LI LO TS
3	EC50 = 2.3 nM	TI LI LO TS
4	EC50 = 3.5 nM	TI LI LO TS
5	EC50 = 33 nM	TI LI LO TS
6	EC50 = 55 nM	TI LI LO TS
7	EC50 = 820 nM	TI LI LO TS
8	Ki = 2.97 nM	TI LI LO TS
9	Ki = 7.58 nM	TI LI LO TS
10	Ki = 15 nM	TI LI LO TS
11	Ki = 72 nM	TI LI LO TS
12	Ki = 293 nM	TI LI LO TS
13	Ki = 1100 nM	TI LI LO TS
14	Ki > 80000 nM	TI LI LO TS

Biochemical Assays

1	Ki = 13.2 nM
2	Ki = 50 nM
3	Ki = 52 nM
4	Ki = 290 nM
5	Ki = 1600 nM

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han