Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(15S)-prostaglandin E2

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PubChem ID

CID: 5280360

SID: 99431525

Canonical SMILES	CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show/Hide
Compound Formula	C20H32O5

Compound Structure

Protein Name

Protein Info

Prostaglandin E2 receptor EP4 subtype

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Prostanoid receptor

Uniprot ID

P35408

Gene Name

PTGER4

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000064	Chem-1 Cell Line Info	Rattus norvegicus (Rat)	3
1	IC50 = 1.1 nM	TI LI LO TS
2	IC50 = 5 nM	TI LI LO TS
3	Ki = 0.45 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 7.5 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	4
1	EC50 = 3 nM	TI LI LO TS
2	IC50 = 0.55 nM	TI LI LO TS
3	Ki = 0.11 nM	TI LI LO TS
4	Ki = 0.79 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.7 nM	TI LI LO TS
CL000314	HEK293T/17 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 0.02 nM	TI LI LO TS
2	EC50 = 0.583 nM	TI LI LO TS

Biochemical Assays