Brief Information of the Compound and Protein
Compound Name
US8653092, 67
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PubChem ID
CID: 57495353
SID: 163626422
Canonical SMILES
CCC(=O)N1CC[C@@H](C1)Nc1ncnc2CCN(Cc12)c1cnc(OC)c(c1)C(F)(F)F
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Compound Formula C21H25F3N6O2
Compound Structure
Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
O00329
Gene Name
PIK3CD
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  2
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
2
IC50 = 159 nM
   TI
   LI
   LO
   TS
CL000019 Rat1 Rattus norvegicus (Rat)  1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.5 nM
2 IC50 = 11 nM
3 IC50 = 23 nM