Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one

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PubChem ID

CID: 135399235

SID: 12013177

Canonical SMILES	CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1 Show/Hide
Compound Formula	C13H13N5O2

Compound Structure

Protein Name

Protein Info

G-protein coupled receptor 35

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Carboxylic acid receptor

Kynurenic acid receptor

Uniprot ID

Q9HC97

Gene Name

GPR35

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 1960 nM	TI LI LO TS
2	EC50 = 2240 nM	TI LI LO TS
3	Ki = 401 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	EC50 = 62.83 nM	TI LI LO TS
2	EC50 = 160 nM	TI LI LO TS
3	EC50 = 4200 nM	TI LI LO TS
4	IC50 = 48.15 nM	TI LI LO TS
CL000007	HT-29 Cell Line Info	Homo sapiens (Human)	6
1	EC50 = 110 nM	TI LI LO TS
2	EC50 = 140 nM	TI LI LO TS
3	EC50 = 160 nM	TI LI LO TS
4	EC50 = 340 nM	TI LI LO TS
5	IC50 = 1220 nM	TI LI LO TS
6	IC50 = 10500 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 3250 nM	TI LI LO TS
2	EC50 = 4200 nM	TI LI LO TS
3	EC50 = 5300 nM	TI LI LO TS
4	EC50 = 6100 nM	TI LI LO TS
5	EC50 = 6200 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 130 nM