Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethylfuran-2-ylidene]propanedinitrile
    Show/Hide
 PubChem ID
CID: 12138435
SID: 124399480
Canonical SMILES
CC1=C(C#N)C(OC1(C)c1ccc(Cl)c(Cl)c1)=C(C#N)C#N
    Show/Hide
Compound Formula C16H9Cl2N3O
Compound Structure
Protein Name
 Protein Info 
G-protein coupled receptor 35
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Carboxylic acid receptor
>
Kynurenic acid receptor
Uniprot ID
Q9HC97
Gene Name
GPR35
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 655 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
2
EC50 = 10200 nM
   TI
   LI
   LO
   TS
CL000007 HT-29
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
2
IC50 = 60 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 10200 nM
   TI
   LI
   LO
   TS