Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene

Show/Hide

PubChem ID

CID: 5311501

SID: 14782868

Canonical SMILES	Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 Show/Hide
Compound Formula	C27H26N2O3

Compound Structure

Protein Name

Protein Info

Cannabinoid receptor 1

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Cannabinoid receptor

Uniprot ID

P21554

Gene Name

CNR1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000064	Chem-1 Cell Line Info	Rattus norvegicus (Rat)	2
1	IC50 = 200 nM	TI LI LO TS
2	Ki = 150 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	17
1	EC50 = 31.62 nM	TI LI LO TS
2	EC50 = 37 nM	TI LI LO TS
3	EC50 = 50.12 nM	TI LI LO TS
4	EC50 = 316.23 nM	TI LI LO TS
5	Ki = 1.9 nM	TI LI LO TS
6	Ki = 2.5 nM	TI LI LO TS
7	Ki = 11.3 nM	TI LI LO TS
8	Ki = 12.4 nM	TI LI LO TS
9	Ki = 12.5 nM	TI LI LO TS
10	Ki = 19 nM	TI LI LO TS
11	Ki = 40 nM	TI LI LO TS
12	Ki = 52.4 nM	TI LI LO TS
13	Ki = 79.43 nM	TI LI LO TS
14	Ki = 94.5 nM	TI LI LO TS
15	Ki = 152.2 nM	TI LI LO TS
16	Ki = 3800 nM	TI LI LO TS
17	Ki = 3802 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 2.5 nM	TI LI LO TS
2	Ki = 8.72 nM	TI LI LO TS
CL000880	COS Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	Ki = 21 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	8
1	EC50 = 12.3 nM	TI LI LO TS
2	EC50 = 44 nM	TI LI LO TS
3	EC50 = 112 nM	TI LI LO TS
4	IC50 = 140 nM	TI LI LO TS
5	Ki = 9.2 nM	TI LI LO TS
6	Ki = 20 nM	TI LI LO TS
7	Ki = 21 nM	TI LI LO TS
8	Ki = 46 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	3
1	Ki = 28.8 nM	TI LI LO TS
2	Ki = 36.2 nM	TI LI LO TS
3	Ki = 45.6 nM	TI LI LO TS
CL000107	HEK293S Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 110 nM	TI LI LO TS
2	IC50 = 59 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	Ki = 12.59 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 1760 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 7.2 nM
2	EC50 = 16 nM
3	IC50 = 16 nM
4	IC50 = 63.1 nM
5	Ki = 1.89 nM
6	Ki = 1.9 nM
7	Ki = 6.06 nM
8	Ki = 13.3 nM
9	Ki = 14 nM
10	Ki = 16.1 nM
11	Ki = 21 nM
12	Ki = 40.9 nM
13	Ki = 45.59 nM
14	Ki = 45.6 nM
15	Ki = 52.4 nM
16	Ki = 140 nM
17	Ki = 3802 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han