Brief Information of the Compound and Protein
Compound Name
4-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
    Show/Hide
PubChem ID
CID: 25129527
SID: 56453873
Canonical SMILES
CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(Cl)cc1
    Show/Hide
Compound Formula C15H18ClN5
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  3
1
Ki = 1.995 nM
   TI
   LI
   LO
   TS
2
Ki = 63.1 nM
   TI
   LI
   LO
   TS
3
Ki = 199.53 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 3.162 nM
   TI
   LI
   LO
   TS