Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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 PubChem ID
CID: 10184653
SID: 15180141
Canonical SMILES
CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
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Compound Formula C24H25ClFN5O3
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1401 nM
   TI
   LI
   LO
   TS
CL000323 LoVo
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975
 Cell Line Info 
Homo sapiens (Human)  4
1
EC50 = 7.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 30 nM
   TI
   LI
   LO
   TS
3
IC50 = 23 nM
   TI
   LI
   LO
   TS
4
IC50 = 714 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  4
1
IC50 = 0.33 nM
   TI
   LI
   LO
   TS
2
IC50 = 9 nM
   TI
   LI
   LO
   TS
3
IC50 = 13 nM
   TI
   LI
   LO
   TS
4
IC50 = 14 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 0.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 15.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM
2 IC50 = 0.5 nM
3 IC50 = 0.67 nM
4 IC50 = 0.97 nM
5 IC50 = 1 nM
6 IC50 < 1 nM
7 IC50 = 1.1 nM
8 IC50 = 1.2 nM
9 IC50 = 1.6 nM
10 IC50 = 2.5 nM
11 IC50 = 3.7 nM
12 IC50 = 3.8 nM
13 IC50 = 6 nM
14 IC50 = 10 nM
15 IC50 = 14 nM
16 IC50 = 22 nM
17 Kd = 0.1 nM
18 Kd = 0.11 nM
19 Kd = 0.12 nM
20 Kd = 0.14 nM
21 Kd = 0.19 nM
22 Kd = 0.2 nM
23 Kd = 0.23 nM
24 Kd = 0.25 nM
25 Kd = 0.61 nM
26 Kd = 1.1 nM