Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

14C-5-hydroxy tryptamine creatinine disulfate

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PubChem ID

CID: 5202

SID: 15120541

Canonical SMILES	NCCc1c[nH]c2ccc(O)cc12 Show/Hide
Compound Formula	C10H12N2O

Compound Structure

Protein Name

Protein Info

5-hydroxytryptamine receptor 1A

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Serotonin receptor

Uniprot ID

P08908

Gene Name

HTR1A

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000049	C6 Cell Line Info	Rattus norvegicus (Rat)	1
1	EC50 = 229.09 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	7
1	EC50 = 3.7 nM	TI LI LO TS
2	EC50 = 27.54 nM	TI LI LO TS
3	EC50 = 147 nM	TI LI LO TS
4	EC50 = 150 nM	TI LI LO TS
5	EC50 = 169.82 nM	TI LI LO TS
6	Ki = 3 nM	TI LI LO TS
7	Ki = 4.5 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	20
1	EC50 = 5.7 nM	TI LI LO TS
2	EC50 = 15.33 nM	TI LI LO TS
3	EC50 = 18 nM	TI LI LO TS
4	EC50 = 30.9 nM	TI LI LO TS
5	EC50 = 33.11 nM	TI LI LO TS
6	EC50 = 39 nM	TI LI LO TS
7	EC50 = 45.3 nM	TI LI LO TS
8	EC50 = 50.12 nM	TI LI LO TS
9	EC50 = 58.88 nM	TI LI LO TS
10	EC50 = 69.18 nM	TI LI LO TS
11	EC50 = 97.7 nM	TI LI LO TS
12	EC50 = 1800 nM	TI LI LO TS
13	Ki = 0.91 nM	TI LI LO TS
14	Ki = 1.1 nM	TI LI LO TS
15	Ki = 1.3 nM	TI LI LO TS
16	Ki = 1.4 nM	TI LI LO TS
17	Ki = 2.08 nM	TI LI LO TS
18	Ki = 2.48 nM	TI LI LO TS
19	Ki = 3.6 nM	TI LI LO TS
20	Ki = 5.5 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	8
1	EC50 = 3.75 nM	TI LI LO TS
2	EC50 = 8.71 nM	TI LI LO TS
3	EC50 = 19 nM	TI LI LO TS
4	Ki = 0.62 nM	TI LI LO TS
5	Ki = 0.9 nM	TI LI LO TS
6	Ki = 1.2 nM	TI LI LO TS
7	Ki = 3.981 nM	TI LI LO TS
8	Ki < 50 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 128.82 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 1.2 nM
2	IC50 = 5.2 nM
3	Ki = 1.259 nM
4	Ki = 2.48 nM
5	Ki = 2.5 nM
6	Ki = 10000 nM

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han