Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

Avandamet

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PubChem ID

CID: 77999

SID: 50086904

Canonical SMILES	CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 Show/Hide
Compound Formula	C18H19N3O3S

Compound Structure

Protein Name

Protein Info

Peroxisome proliferator-activated receptor alpha

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 1

Nuclear hormone receptor subfamily 1 group C

Nuclear hormone receptor subfamily 1 group C member 1

Uniprot ID

Q07869

Gene Name

PPARA

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	EC50 > 1000 nM	TI LI LO TS
2	EC50 > 3000 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	3
1	EC50 = 3390 nM	TI LI LO TS
2	EC50 > 10000 nM	TI LI LO TS
3	EC50 = 10000 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	EC50 = 3460 nM	TI LI LO TS
2	EC50 > 10000 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	EC50 > 10000 nM	TI LI LO TS
2	EC50 = 10580 nM	TI LI LO TS
3	EC50 > 5000 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	EC50 > 10000 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 39 nM	TI LI LO TS
2	EC50 > 10000 nM	TI LI LO TS
3	EC50 > 12000 nM	TI LI LO TS

Biochemical Assays