Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)

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PubChem ID

CID: 3559

SID: 14902191

Canonical SMILES	OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show/Hide
Compound Formula	C21H23ClFNO2

Compound Structure

Protein Name

Protein Info

D(4) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P21917

Gene Name

DRD4

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	14
1	IC50 = 6 nM	TI LI LO TS
2	Ki = 1 nM	TI LI LO TS
3	Ki = 2.1 nM	TI LI LO TS
4	Ki = 2.2 nM	TI LI LO TS
5	Ki = 2.3 nM	TI LI LO TS
6	Ki = 3.3 nM	TI LI LO TS
7	Ki = 5.9 nM	TI LI LO TS
8	Ki = 6 nM	TI LI LO TS
9	Ki = 6.026 nM	TI LI LO TS
10	Ki = 6.3 nM	TI LI LO TS
11	Ki = 6.31 nM	TI LI LO TS
12	Ki = 7.3 nM	TI LI LO TS
13	Ki = 42 nM	TI LI LO TS
14	Ki = 103 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 2.2 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	EC50 > 10000 nM	TI LI LO TS
2	Ki = 2.3 nM	TI LI LO TS
3	Ki = 5 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	Ki = 2.2 nM	TI LI LO TS
2	Ki = 3.6 nM	TI LI LO TS

Biochemical Assays