Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one
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 PubChem ID
CID: 55245
SID: 12013919
Canonical SMILES
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
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Compound Formula C29H35NO2
Compound Structure
Protein Name
 Protein Info 
Androgen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 4
Uniprot ID
P10275
Gene Name
AR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 7.8 nM
   TI
   LI
   LO
   TS
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
Ki = 22 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 6.9 nM
   TI
   LI
   LO
   TS
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  3
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
   TI
   LI
   LO
   TS
3
IC50 = 5 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 5.95 nM
   TI
   LI
   LO
   TS
CL000141 LNCaP
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 11.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5 nM
2 IC50 = 6.9 nM
3 IC50 = 8.8 nM
4 IC50 = 63.1 nM
5 IC50 = 89 nM
6 Ki = 0.65 nM
7 Ki = 4.6 nM
8 Ki = 8.4 nM
9 Ki = 10.6 nM