Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol

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PubChem ID

CID: 9887712

SID: 14855234

Canonical SMILES	CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show/Hide
Compound Formula	C21H25ClO6

Compound Structure

Protein Name

Protein Info

Sodium/glucose cotransporter 1

Protein Classification

Transporter

Electrochemical transporter

SLC superfamily of solute carriers

SLC05 family of sodium-dependent glucose transporters

Uniprot ID

P13866

Gene Name

SLC5A1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	7
1	EC50 = 428.5 nM	TI LI LO TS
2	EC50 = 860 nM	TI LI LO TS
3	EC50 = 1390 nM	TI LI LO TS
4	IC50 = 370 nM	TI LI LO TS
5	IC50 = 629 nM	TI LI LO TS
6	IC50 = 800 nM	TI LI LO TS
7	IC50 = 1200 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 593 nM	TI LI LO TS
2	IC50 = 800 nM	TI LI LO TS
3	IC50 = 891 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	IC50 = 890 nM	TI LI LO TS
CL000386	Flp-In-CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 803 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	IC50 = 810 nM	TI LI LO TS
2	IC50 = 1800 nM	TI LI LO TS
3	IC50 = 3100 nM	TI LI LO TS
CL000035	NIH 3T3 Cell Line Info	Mus musculus (Mouse)	1
1	IC50 = 12300 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 1400 nM
2	IC50 = 1391 nM